Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand

Journal of Medicinal Chemistry

Volumn 49, Issue 25, 2006, Pages 7317-7324

  Marzano, Cristina ^a   Pellei, Maura ^b   Colavito, Davide ^c   Alidori, Simone ^b   Lobbia, Giancarlo Gioia ^b   Gandin, Valentina ^a   Tisato, Francesco ^d   Santini, Carlo ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c Research and Innovation R and I Company   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACETONITRILE; ANTINEOPLASTIC AGENT; BIS(1,2,4 TRIAZOL 1 YL)ACETATE; CASPASE 3; CISPLATIN; COPPER COMPLEX; METHANOL; PHOSPHINE DERIVATIVE; SODIUM HYDROXIDE; TRIAZOLE DERIVATIVE; TRIS(HYDROXYMETHYL)PHOSPHINE COPPER COMPLEX;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GRANULE; CELL SIZE; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; OVARY CARCINOMA; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CHELATING AGENTS; CISPLATIN; COPPER; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; LIGANDS; ORGANOMETALLIC COMPOUNDS; PHOSPHINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 33845487508     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0601248     Document Type: Article

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