Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrierdisruption and lung injury

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24123-24132

  He, Donghong ^a   Su, Yanlin ^a   Usatyuk, Peter V ^a   Spannhake, Ernst Wm ^b   Kogut, Paul ^a   Solway, Julian ^a   Natarajan, Viswanathan ^a   Zhao, Yutong ^a,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b The Johns Hopkins University   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LUNG INJURY; AIRWAY INFLAMMATION; ANTI-INFLAMMATORIES; BRONCHOALVEOLAR LAVAGE FLUID; CELL SURVIVAL; CELL-CELL JUNCTIONS; CELLULAR EFFECTS; CYTOSKELETAL REARRANGEMENTS; DOMINANT NEGATIVE; DOSE-DEPENDENT; E-CADHERINS; EPITHELIAL BARRIER; EPITHELIAL CELLS; FOCAL ADHESION KINASE; HUMAN BRONCHIAL EPITHELIAL CELLS; INTRATRACHEAL; LIPOPOLYSACCHARIDES; LUNG INJURY; LYSOPHOSPHATIDIC ACID; MURINE MODEL; OVER-EXPRESSION; POST TREATMENT; PRE-TREATMENT; PROTEIN KINASE; PROTEIN KINASE C; RE-LOCALIZATION; SMALL INTERFERING RNA; TRANSEPITHELIAL ELECTRICAL RESISTANCES; TYROSINE PHOSPHORYLATION;

ACIDS; AMINO ACIDS; BIOLOGICAL ORGANS; CYTOLOGY; GENE EXPRESSION; LEAKAGE (FLUID); NUCLEIC ACIDS; PHOSPHOLIPIDS; PHOSPHORYLATION; POLYSACCHARIDES; RNA;

CELL MEMBRANES;

EGTAZIC ACID; ENDOTOXIN; FOCAL ADHESION KINASE; LIPOPOLYSACCHARIDE; LYSOPHOSPHATIDIC ACID; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C DELTA; PROTEIN KINASE C LAMBDA; SMALL INTERFERING RNA; TYROSINE; UVOMORULIN;

ACUTE LUNG INJURY; ADENOVIRUS INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CELL JUNCTION; CONTROLLED STUDY; CYTOPLASM; ELECTRIC RESISTANCE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE MICROSCOPY; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTECTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; CADHERINS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FOCAL ADHESION KINASE 1; HUMANS; LIPOPOLYSACCHARIDES; LUNG INJURY; LYSOPHOSPHOLIPIDS; MICE; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; RECEPTORS, LYSOPHOSPHATIDIC ACID; RESPIRATORY MUCOSA;

MURINAE;

EID: 69949131592     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007393     Document Type: Article

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