Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-κB and IFN-γ/STAT1 pathways

Journal of Clinical Immunology

Volumn 28, Issue 5, 2008, Pages 512-519

  Xu, Yan ^a,c   Feng, Dechun ^a,c   Wang, Ying ^b   Lin, Shuting ^b   Xu, Lingyun ^a,b,d  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d Building I ^*  (China)

Author keywords

Concanavalin A induced hepatitis; NF B; Sodium tanshinone IIA sulfonate; STAT1

Indexed keywords

ALANINE AMINOTRANSFERASE; CONCANAVALIN A; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; RANTES; STAT1 PROTEIN; TANSHINONE; TANSHINONE IIA SULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; C57BL 6 MOUSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; EXPERIMENTAL MODEL; HEPATITIS; IN VIVO STUDY; INFLAMMATORY INFILTRATE; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROVOCATION TEST; REPEATED DRUG DOSE;

ANIMALS; CONCANAVALIN A; HEPATITIS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAPERITONEAL; INTERFERON TYPE II; LIVER; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHENANTHRENES; PHYTOTHERAPY; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 51349128552     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-008-9206-3     Document Type: Article

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