The role of microbial flora on the ocular surface

Current Opinion in Allergy and Clinical Immunology

Volumn 9, Issue 5, 2009, Pages 466-470

  Miller, Darlene ^a   Iovieno, Alfonso ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Microbial flora; Ocular surface; Toll like receptor

Indexed keywords

MUCIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR;

AUTOIMMUNE DISEASE; CELL DAMAGE; CHLAMYDOPHILA PSITTACI; COMMENSAL; CONJUNCTIVA; CORNEA; DRY EYE; EPITHELIUM CELL; EYE ALLERGY; EYE CANCER; EYE DISEASE; EYE INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; KERATITIS; LANGERHANS CELL; MICROBIAL COLONIZATION; MICROFLORA; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; VISION;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL INFECTIONS; CELL COMMUNICATION; DRY EYE SYNDROMES; EYE; EYE NEOPLASMS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNIZATION; MUCINS; TOLL-LIKE RECEPTORS;

EID: 69749091746     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e3283303e1b     Document Type: Review

References (32)

1. Graham JE, Moore JE, Jiru X, et al. Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes. Invest Ophthalmol Vis Sci 2007; 48:5616-5623. (Pubitemid 351260863)
2. Ueta M. Innate immunity of the ocular surface and ocular surface inflammatory disorders. Cornea 2008; 27 (Suppl 1):S31-S40. This paper provides a current update on the innate immunity of the ocular surface epithelium and the abnormalities associated with ocular surface inflammation.
3. Miller D. Ocular Infections. In Textbook of Diagnostic Microbiology. Edited by Mahon C, Lehman, DC & Manuselis, G. (editors): Elsevier; 2007:1072-1103.
4. Cario E. Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction. Curr Opin Gastroenterol 2008; 24:725-732.
5. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br J Dermatol 2008; 158:442-455.
6. Pamer EG. Immune responses to commensal and environmental microbes. Nat Immunol 2007; 8:1173-1178. (Pubitemid 350011753)
7. Kumar A, Yu FS. Toll-like receptors and corneal innate immunity. Curr Mol Med 2006; 6:327-337.
8. Pearlman E, Johnson A, Adhikary G, et al. Toll-like receptors at the ocular surface. Ocul Surf 2008; 6:108-116. This paper provides a complete and extensive review about the role of TLR in the ocular surface, with particular attention to their involvement in the pathogenesis of infectious diseases.
9. Chang JH, McCluskey PJ, Wakefield D. Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease. Br J Ophthalmol 2006; 90:103-108. (Pubitemid 43029907)
10. Magalhaes JG, Tattoli I, Girardin SE. The intestinal epithelial barrier: how to distinguish between the microbial flora and pathogens. Semin Immunol 2007; 19:106-115. (Pubitemid 46810286)
11. Edelman SM, Kasper DL. Symbiotic commensal bacteria direct maturation of the host immune system. Curr Opin Gastroenterol 2008; 24:720-724.
12. Gilger BC. Immunology of the ocular surface. Vet Clin North Am Small Anim Pract 2008; 38:223-231; v.
13. Bonini S, Micera A, Iovieno A, Lambiase A. Expression of Toll-like receptors in healthy and allergic conjunctiva. Ophthalmology 2005; 112:e1-1528.e8; discussion 1548-11529 (Pubitemid 41725407)
14. Kojima K, Ueta M, Hamuro J, et al. Human conjunctival epithelial cells express functional Toll-like receptor 5. Br J Ophthalmol 2008; 92:411-416. This study discusses an example of how subcellular localization and ligand-specificity allow TLR to discriminate between pathogenic and harmless bacteria on the ocular surface.
15. Kumar A, Zhang J, Yu FS. Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating pro-flammatory cytokine secretion. Invest Ophthalmol Vis Sci 2004; 45:3513-3522. (Pubitemid 39298569)
16. Kumar A, Zhang J, Yu FS. Toll-like receptor 2-mediated expression of beta defensis-2 in human corneal epithelial cells. Microbes in Infect 2006; 8:380-389. (Pubitemid 43214600)
17. Ueta M, Nochi T, Jang MH, et al. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol 2004; 173:3337-3347. (Pubitemid 39142043)
18. Yamagami S, Yokoo S, Amano S, Ebihara N. Characterization of bone marrow derived cells in the substantia propria of the human conjunctiva. Invest Ophthalmol Vis Sci 2007; 48:4476-4481. (Pubitemid 351260962)
19. Hornef MW, Henriques-Normark B, Normark S. The function and biological role of toll-like receptors in infectious diseases: an update. Curr Opin Infect Dis 2008; 21:304-312. (Pubitemid 351620386)
20. Zhang J, Xu K, Ambati B, Yu FS. Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin. Invest Ophthalmol Vis Sci 2003; 44:4247-4254. (Pubitemid 37186258)
21. Shaw MH, Reimer T, Kim YG, Nunez G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol 2008; 20:377-382. A complete short review on structure and function of NLR family components.
22. Hedl M, Li J, Cho JH, Abraham C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A 2007; 104:19440-19445.
23. Rakoff-Nahoum S, Medzhitov R. Role of the innate immune system and hostcommensal mutualism. Curr Top Microbiol Immunol 2006; 308:1-18. (Pubitemid 47400295)
24. Fujimoto C, Shi G, Gery I. Microbial products trigger autoimmune ocular inflammation. Ophthalmic Res 2008; 40:193-199. (Pubitemid 351562902)
25. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea 2008; 27 (Suppl 1):S9-S11.
26. Berry M, Corfield AP, Harris A, Khan-Lim D. Functional processing of ocular mucins. Adv Exp Med Biol 2002; 506:283-288.
27. Berry M, Pult H, Purslow C, Murphy PJ. Mucins and ocular signs in symptomatic and asymptomatic contact lens wear. Optom Vis Sci 2008; 85:E930-E938.
28. Mantelli F, Argueso P. Function of ocular surface mucins in health and disease. Curr Opin Allergy Clin Immunol 2008; 8:477-483.
29. Verma V, Shen D, Sieving PC, Chan CC. The role of infectious agents in the etiology of ocular adnexal neoplasia. Surv Ophthalmol 2008; 53:312-331. This is an excellent and comprehensive review that discusses the potential role of infectious agents as etiological agents in ocular adnexal neoplasia. Elucidation of the roles of bacteria and viral pathogen could lead to improved therapy and patient outcomes. (Pubitemid 351842561)
30. Ferreri AJ, Dolcetti R, Dognini GP, et al. Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control study. Int J Cancer 2008; 123:1089-1093.
31. Ponzoni M, Ferreri AJ, Guidoboni M, et al. Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods. Clin Cancer Res 2008; 14:5794-5800.
32. Lee SB, Yang JW, Kim CS. The association between conjunctival MALT lymphoma and Helicobacter pylori. Br J Ophthalmol 2008; 92:534-536.