Microbial products trigger autoimmune ocular inflammation

Ophthalmic Research

Volumn 40, Issue 3-4, 2008, Pages 193-199

  Fujimoto, Chiaki ^a   Shi, Guangpu ^a   Gery, Igal ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

Autoimmunity; Cytokines; Microbial products; Ocular inflammation; Pertussis toxin; Toll like receptor ligands; Toll like receptors

Indexed keywords

ALPHA4 INTEGRIN; GAMMA INTERFERON; L SELECTIN; LYSOZYME; PERTUSSIS TOXIN; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; EYE INFLAMMATION; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; BACTERIA; BACTERIAL TOXINS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; INTEGRIN ALPHA2; INTERFERON TYPE II; L-SELECTIN; LIGANDS; MICE; MICE, TRANSGENIC; MURAMIDASE; POLYSACCHARIDES, BACTERIAL; TOLL-LIKE RECEPTORS; UVEITIS;

EID: 42449124620     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119875     Document Type: Article

References (24)

1. Oldstone MB: Molecular mimicry and immune-mediated diseases. FASEB J 1998;12:1255-1265.
2. Barnaba V, Sinigaglia F: Molecular mimicry and T cell-mediated autoimmune disease. J Exp Med 1997;185:1529-1531.
3. Singh VK, Yamaki K, Abe T, Shinohara T: Molecular mimicry between uveitopathogenic site of retinal S-antigen and Escherichia coli protein: induction of experimental autoimmune uveitis and lymphocyte cross-reaction. Cell Immunol 1989;122:262-273.
4. Singh VK, Yamaki K, Donoso LA, Shinohara T: Molecular mimicry. Yeast histone H3-induced experimental autoimmune uveitis. J Immunol 1989;142:1512-1517.
5. Singh VK, Kalra HK, Yamaki K, Abe T, Donoso LA, Shinohara T: Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides. Induction of experimental autoimmune uveitis in Lewis rats. J Immunol 1990;144:1282-1287.
6. Janeway CA Jr, Medzhitov R: Innate immune recognition. Annu Rev Immunol 2002;20:197-216.
7. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
8. Pulendran B: Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol 2005;174:2457-2465.
9. Walker LS, Abbas AK: The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2002;2:11-19.
10. Starr TK, Jameson SC, Hogquist KA: Positive and negative selection of T cells. Annu Rev Immunol 2003;21:139-176.
11. Waldner H, Collins M, Kuchroo VK: Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. J Clin Invest 2004;113:990-997.
12. Danke NA, Koelle DM, Yee C, Beheray S, Kwok WW: Autoreactive T cells in healthy individuals. J Immunol 2004;172:5967-5972.
13. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712.
14. Siegelman MH, Stanescu D, Estess P: The CD44-initiated pathway of T-cell extravasation uses VLA-4 but not LFA-1 for firm adhesion. J Clin Invest 2000;105:683-691.
15. Lai JC, Fukushima A, Wawrousek EF, Lobanoff MC, Charukamnoetkanok P, Smith-Gill SJ, Vistica BP, Lee RS, Egwuagu CE, Whitcup SM, Gery I: Immunotolerance against a foreign antigen transgenically expressed in the lens. Invest Ophthalmol Vis Sci 1998;39:2049-2057.
16. Ho WY, Cooke MP, Goodnow CC, Davis MM: Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med 1994;179:1539-1549.
17. Kim SJ, Zhang M, Vistica BP, Chan CC, Shen DF, Wawrousek EF, Gery I: Induction of ocular inflammation by T-helper lymphocytes type 2. Invest Ophthalmol Vis Sci 2002;43:758-765.
18. Fujimoto C, Yu CR, Shi G, Vistica BP, Wawrousek EF, Klinman DM, Chan CC, Egwuagu CE, Gery I: Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production. J Immunol 2006;177:6896-6903.
19. Chen J, Fujimoto C, Vistica BP, He J, Wawrousek EF, Kelsall B, Gery I: Active participation of antigen-nonspecific lymphoid cells in immune-mediated inflammation. J Immunol 2006;177:3362-3368.
20. Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T: Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 2006;212:8-27.
21. Shevach EM, McHugh RS, Piccirillo CA, Thornton AM: Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev 2001;182:58-67.
22. Stockinger B: T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv Immunol. 1999;71:229-265.
23. Choi S, Schwartz RH: Molecular mechanisms for adaptive tolerance and other T cell anergy models. Semin Immunol 2007;19:140-152.
24. Weaver CT, Hatton RD, Mangan PR, Harrington LE: IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-852.