Innate immunity of the ocular surface and ocular surface inflammatory disorders

Cornea

Volumn 27, Issue SUPPL. 1, 2008, Pages

  Ueta, Mayumi ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Gene expression analysis; Innate immunity; Ocular surface epithelium; Single nucleotide polymorphism; Stevens Johnson syndrome; Toll like receptor

Indexed keywords

ARGININE; CD14 ANTIGEN; GLUTAMINE; I KAPPA B; I KAPPA B ZETA; INTERLEUKIN 1ALPHA; INTERLEUKIN 4 RECEPTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; NFKBIZ PROTEIN, HUMAN; NUCLEAR PROTEIN; TOLL LIKE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOWN REGULATION; ENVIRONMENTAL FACTOR; EYE; EYE INFLAMMATION; GENE EXPRESSION; HEREDITY; HUMAN; INNATE IMMUNITY; JAPANESE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS; UPREGULATION; ASIAN; CELL CULTURE; DRUG EFFECT; EPITHELIUM; GENETICS; IMMUNOLOGY; METABOLISM; MUCOSA;

ASIAN CONTINENTAL ANCESTRY GROUP; CELLS, CULTURED; DOWN-REGULATION; EPIDERMAL NECROLYSIS, TOXIC; EPITHELIUM; EYE; GENE EXPRESSION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1ALPHA; LIPOPOLYSACCHARIDES; MUCOUS MEMBRANE; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-4; RNA, MESSENGER; STEVENS-JOHNSON SYNDROME; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 58149216785     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e31817f2a7f     Document Type: Article

References (19)

1. Ueta M, Nochi T, Jang MH, et al. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004;173:3337-47.
2. Ueta M, Hamuro J, Kiyono H, et al. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005;331:285-294.
3. Hozono Y, Ueta M, Hamuro J, et al. Human corneal epithelial cells respond to ocular-pathogenic, but not to nonpathogenic-flagellin. Biochem Biophys Res Commun. 2006;347:238-247.
4. Kojima K, Ueta M, Hamuro J, et al. Human conjunctival epithelial cells express functional Toll-like receptor 5. Br J Ophthalmol. 2008;92:411-416.
5. Ueta M, Iida T, Sakamoto M, et al. Polyclonality of Staphylococcus epidermidis residing on the healthy ocular surface. J Med Microbiol. 2007;56:77-82.
6. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17:1-14.
7. Ueta M, Hamuro J, Yamamoto M, et al. Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta genedisrupted mice. Invest Ophthalmol Vis Sci. 2005;46:579-588.
8. Ueta M, Hamuro J, Ueda E, et al. Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of I kappa B zeta -/- mice. Invest Ophthalmol Vis Sci. 2008; Epub ahead of print.
9. Yamamoto M, Yamazaki S, Uematsu S, et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004;430:218-222.
10. Ueta M, Sotozono C, Inatomi T, et al. Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br J Ophthalmol. 2007;91:962-965.
11. Sotozono C, Ang LP, Koizumi N, et al. New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Ophthalmology. 2007;114:1294-1302.
12. Sotozono C, Inagaki K, Fujita A, et al. Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea. Cornea. 2002;21:S94-S101.
13. Yamazaki S, Muta T, Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem. 2001;276:27657-27662.
14. Correia O, Delgado L, Roujeau JC, et al. Soluble interleukin 2 receptor and interleukin 1alpha in toxic epidermal necrolysis: a comparative analysis of serum and blister fluid samples. Arch Dermatol. 2002;138: 29-32.
15. Ueta M, Sotozono C, Inatomi T, et al. Association of IL4R polymorphisms with Stevens-Johnson syndrome. J Allergy Clin Immunol. 2007;120:1457-1459.
16. Ueta M, Sotozono C, Tokunaga K, et al. Strong Association Between HLA-A*0206 and Stevens-Johnson Syndrome in the Japanese. Am J Ophthalmol. 2007;143:367-368.
17. Ueta M, Sotozono C, Inatomi T, et al. Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications. Invest Ophthalmol Vis Sci. 2008;49:1809-1813.
18. Ueta M, Tokunaga K, Sotozono C, et al. HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. Mol Vis. 2008;14:550-555.
19. Ueta M, Sotozono C, Inatomi T, et al. Association of Fas ligand gene polymorphism with Stevens-Johnson syndrome. Br J Ophthalmol. 2008; 92 in press.