Synthesis and antitumor evaluation of thiophene analogs of kigelinone

Letters in Organic Chemistry

Volumn 6, Issue 4, 2009, Pages 278-281

  Valderrama, Jaime A ^a   Espinozaa, Omar ^a   Rodriguez, Jaime ^b   Theoduloz, Cristina ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSIDAD DE TALCA   (Chile)

Author keywords

Benzo b thiophenes; Citotoxicity; Diels Alder reaction; Oxidative deprotection; Quinones; Regioisomers

Indexed keywords

EID: 69549121983     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017809788490006     Document Type: Article

References (24)

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16. 4S: C, 57.59; H, 4.03; S, 12.81. Found: C, 57.21; H, 3.99; S, 12.76.
17. The LUMO eigenvector coefficients (eV) were determined using the semiempirical AM1 method implemented in the PC Spartan Pro Inc package.
18. 4S: C, 61.30; H, 3.67; S, 11.69. Found: C, 61.17; H, 3.53; S, 11.76.
19. 4S: C, 61.76, H, 2.96, S, 11.79. Found: C, 61.56; H, 3.08, S, 11.67.
20. 4S: C, 60.46; H, 2.34; S, 12.42. Found: C, 60.01; H, 2.99; S, 12.3.
21. LUMO eigenvectors (eV): Compound 14: C-5 = -0.2634; C-6 = 0.2307. Compound 15: C-5 = -0.3126; C-6 = -0.2291. HOMO eigenvectors (eV): silyloxydiene: C-1 = -0.4744 , C-4 = 0.4929.
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