-
1
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
2
-
-
0017618537
-
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
-
Sulston J.E., and Horvitz H.R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56 (1977) 110-156
-
(1977)
Dev. Biol.
, vol.56
, pp. 110-156
-
-
Sulston, J.E.1
Horvitz, H.R.2
-
4
-
-
33846445346
-
Non-developmentally programmed cell death in Caenorhabditis elegans
-
Kourtis N., and Tavernarakis N. Non-developmentally programmed cell death in Caenorhabditis elegans. Semin. Cancer Biol. 17 (2007) 122-133
-
(2007)
Semin. Cancer Biol.
, vol.17
, pp. 122-133
-
-
Kourtis, N.1
Tavernarakis, N.2
-
6
-
-
0031731989
-
Genetics of programmed cell death in C. elegans: past, present and future
-
Metzstein M.M., Stanfield G.M., and Horvitz H.R. Genetics of programmed cell death in C. elegans: past, present and future. Trends Genet. 14 (1998) 410-416
-
(1998)
Trends Genet.
, vol.14
, pp. 410-416
-
-
Metzstein, M.M.1
Stanfield, G.M.2
Horvitz, H.R.3
-
9
-
-
0032509302
-
Genome Sequence of the Nematode C. elegans: a Platform for Investigating Biology
-
The C. elegans Sequencing Consortium
-
The C. elegans Sequencing Consortium. Genome Sequence of the Nematode C. elegans: a Platform for Investigating Biology. Science 282 (1998) 2012-2018
-
(1998)
Science
, vol.282
, pp. 2012-2018
-
-
-
11
-
-
0025328727
-
Vectors for low copy transformation of C. elegans
-
Fire A., Kondo K., and Waterston R. Vectors for low copy transformation of C. elegans. Nucleic Acids Res. 18 (1990) 4269-4270
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 4269-4270
-
-
Fire, A.1
Kondo, K.2
Waterston, R.3
-
12
-
-
0038725897
-
Genome-wide RNAi screening in Caenorhabditis elegans
-
Kamath R.S., and Ahringer J. Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30 (2003) 313-321
-
(2003)
Methods
, vol.30
, pp. 313-321
-
-
Kamath, R.S.1
Ahringer, J.2
-
13
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
14
-
-
1842583789
-
Development by self-digestion: molecular mechanisms and biological functions of autophagy
-
Levine B., and Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6 (2004) 463-477
-
(2004)
Dev. Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
15
-
-
27644484061
-
Autophagy: molecular machinery for self-eating
-
Yorimitsu T., and Klionsky D.J. Autophagy: molecular machinery for self-eating. Cell Death Differ. 12 Suppl. 2 (2005) 1542-1552
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1542-1552
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
16
-
-
33745026738
-
Autophagy and aging: the importance of maintaining "clean" cells
-
Cuervo A.M., Bergamini E., Brunk U.T., Droge W., Ffrench M., and Terman A. Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 1 (2005) 131-140
-
(2005)
Autophagy
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Droge, W.4
Ffrench, M.5
Terman, A.6
-
17
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B., and Kroemer G. Autophagy in the pathogenesis of disease. Cell 132 (2008) 27-42
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
18
-
-
50249103834
-
The cell biology of autophagy in metazoans: a developing story
-
Melendez A., and Neufeld T.P. The cell biology of autophagy in metazoans: a developing story. Development 135 (2008) 2347-2360
-
(2008)
Development
, vol.135
, pp. 2347-2360
-
-
Melendez, A.1
Neufeld, T.P.2
-
19
-
-
27644493346
-
The pleiotropic role of autophagy: from protein metabolism to bactericide
-
Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ. 12 Suppl. 2 (2005) 1535-1541
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1535-1541
-
-
Mizushima, N.1
-
20
-
-
38949120953
-
Autophagy and cell death in Caenorhabditis elegans
-
Samara C., and Tavernarakis N. Autophagy and cell death in Caenorhabditis elegans. Curr. Pharm. Des. 14 (2008) 97-115
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 97-115
-
-
Samara, C.1
Tavernarakis, N.2
-
21
-
-
35048835279
-
Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans
-
Aladzsity I., Toth M.L., Sigmond T., Szabo E., Bicsak B., Barna J., Regos A., Orosz L., Kovacs A.L., and Vellai T. Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics 177 (2007) 655-660
-
(2007)
Genetics
, vol.177
, pp. 655-660
-
-
Aladzsity, I.1
Toth, M.L.2
Sigmond, T.3
Szabo, E.4
Bicsak, B.5
Barna, J.6
Regos, A.7
Orosz, L.8
Kovacs, A.L.9
Vellai, T.10
-
22
-
-
33748339570
-
C. elegans feeding defective mutants have shorter body lengths and increased autophagy
-
Morck C., and Pilon M. C. elegans feeding defective mutants have shorter body lengths and increased autophagy. BMC Dev. Biol. 6 (2006) 39
-
(2006)
BMC Dev. Biol.
, vol.6
, pp. 39
-
-
Morck, C.1
Pilon, M.2
-
23
-
-
33847355083
-
The l-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy
-
Gomez T.A., Banfield K.L., Trogler D.M., and Clarke S.G. The l-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. Dev. Biol. 303 (2007) 493-500
-
(2007)
Dev. Biol.
, vol.303
, pp. 493-500
-
-
Gomez, T.A.1
Banfield, K.L.2
Trogler, D.M.3
Clarke, S.G.4
-
24
-
-
0031574450
-
Targeted gene disruption of the Caenorhabditis elegans l-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes
-
Kagan R.M., Niewmierzycka A., and Clarke S. Targeted gene disruption of the Caenorhabditis elegans l-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes. Arch. Biochem. Biophys. 348 (1997) 320-328
-
(1997)
Arch. Biochem. Biophys.
, vol.348
, pp. 320-328
-
-
Kagan, R.M.1
Niewmierzycka, A.2
Clarke, S.3
-
25
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. elegans
-
Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301 (2003) 1387-1391
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
26
-
-
32544432831
-
Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans
-
Rowland A.M., Richmond J.E., Olsen J.G., Hall D.H., and Bamber B.A. Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans. J. Neurosci. 26 (2006) 1711-1720
-
(2006)
J. Neurosci.
, vol.26
, pp. 1711-1720
-
-
Rowland, A.M.1
Richmond, J.E.2
Olsen, J.G.3
Hall, D.H.4
Bamber, B.A.5
-
27
-
-
33745866244
-
Shaping cellular form and function by autophagy
-
Bamber B.A., and Rowland A.M. Shaping cellular form and function by autophagy. Autophagy 2 (2006) 247-249
-
(2006)
Autophagy
, vol.2
, pp. 247-249
-
-
Bamber, B.A.1
Rowland, A.M.2
-
28
-
-
0031840035
-
unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors
-
Prasad B.C., Ye B., Zackhary R., Schrader K., Seydoux G., and Reed R.R. unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors. Development 125 (1998) 1561-1568
-
(1998)
Development
, vol.125
, pp. 1561-1568
-
-
Prasad, B.C.1
Ye, B.2
Zackhary, R.3
Schrader, K.4
Seydoux, G.5
Reed, R.R.6
-
29
-
-
46749145822
-
Mechanisms of aging and energy metabolism in Caenorhabditis elegans
-
Artal-Sanz M., and Tavernarakis N. Mechanisms of aging and energy metabolism in Caenorhabditis elegans. IUBMB Life 60 (2008) 315-322
-
(2008)
IUBMB Life
, vol.60
, pp. 315-322
-
-
Artal-Sanz, M.1
Tavernarakis, N.2
-
30
-
-
44649170501
-
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
-
Smith E.D., Kaeberlein T.L., Lydum B.T., Sager J., Welton K.L., Kennedy B.K., and Kaeberlein M. Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev. Biol. 8 (2008) 49
-
(2008)
BMC Dev. Biol.
, vol.8
, pp. 49
-
-
Smith, E.D.1
Kaeberlein, T.L.2
Lydum, B.T.3
Sager, J.4
Welton, K.L.5
Kennedy, B.K.6
Kaeberlein, M.7
-
31
-
-
35348972430
-
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
-
Bishop N.A., and Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat. Rev. Genet. 8 (2007) 835-844
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 835-844
-
-
Bishop, N.A.1
Guarente, L.2
-
32
-
-
34247158551
-
Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging
-
Ingram D.K., Young J., and Mattison J.A. Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging. Neuroscience 145 (2007) 1359-1364
-
(2007)
Neuroscience
, vol.145
, pp. 1359-1364
-
-
Ingram, D.K.1
Young, J.2
Mattison, J.A.3
-
33
-
-
0001883841
-
Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction
-
Prolla T.A., and Mattson M.P. Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction. Trends Neurosci. 24 (2001) S21-S31
-
(2001)
Trends Neurosci.
, vol.24
-
-
Prolla, T.A.1
Mattson, M.P.2
-
34
-
-
52449086907
-
The insulin paradox: aging, proteotoxicity and neurodegeneration
-
Cohen E., and Dillin A. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat. Rev. Neurosci. 9 (2008) 759-767
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 759-767
-
-
Cohen, E.1
Dillin, A.2
-
35
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A., Hsu A.L., Arantes-Oliveira N., Lehrer-Graiwer J., Hsin H., Fraser A.G., Kamath R.S., Ahringer J., and Kenyon C. Rates of behavior and aging specified by mitochondrial function during development. Science 298 (2002) 2398-2401
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
Fraser, A.G.6
Kamath, R.S.7
Ahringer, J.8
Kenyon, C.9
-
36
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
37
-
-
33947401070
-
Autophagy regulates ageing in C. elegans
-
Hars E.S., Qi H., Ryazanov A.G., Jin S., Cai L., Hu C., and Liu L.F. Autophagy regulates ageing in C. elegans. Autophagy 3 (2007) 93-95
-
(2007)
Autophagy
, vol.3
, pp. 93-95
-
-
Hars, E.S.1
Qi, H.2
Ryazanov, A.G.3
Jin, S.4
Cai, L.5
Hu, C.6
Liu, L.F.7
-
38
-
-
0030657540
-
daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., and Kenyon C. daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278 (1997) 1319-1322
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
39
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
-
Libina N., Berman J.R., and Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115 (2003) 489-502
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
41
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K., Chen D., and Riddle D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 (2004) 3897-3906
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
42
-
-
0642367846
-
Genetics: influence of TOR kinase on lifespan in C. elegans
-
Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A.L., Orosz L., and Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426 (2003) 620
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
43
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M., Chandra A., Mitic L.L., Onken B., Driscoll M., and Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4 (2008) e24
-
(2008)
PLoS Genet.
, vol.4
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
44
-
-
34249888736
-
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
-
Panowski S.H., Wolff S., Aguilaniu H., Durieux J., and Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447 (2007) 550-555
-
(2007)
Nature
, vol.447
, pp. 550-555
-
-
Panowski, S.H.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
45
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet J.M., Hertweck M., An J.H., Baker J., Hwang J.Y., Liu S., Oliveira R.P., Baumeister R., and Blackwell T.K. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 (2008) 1025-1038
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
46
-
-
34948911093
-
Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity
-
Arum O., and Johnson T.E. Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. J. Gerontol. 62 (2007) 951-959
-
(2007)
J. Gerontol.
, vol.62
, pp. 951-959
-
-
Arum, O.1
Johnson, T.E.2
-
47
-
-
50249145608
-
A dual role of p53 in the control of autophagy
-
Tasdemir E., Chiara Maiuri M., Morselli E., Criollo A., D'Amelio M., Djavaheri-Mergny M., Cecconi F., Tavernarakis N., and Kroemer G. A dual role of p53 in the control of autophagy. Autophagy 4 (2008) 810-814
-
(2008)
Autophagy
, vol.4
, pp. 810-814
-
-
Tasdemir, E.1
Chiara Maiuri, M.2
Morselli, E.3
Criollo, A.4
D'Amelio, M.5
Djavaheri-Mergny, M.6
Cecconi, F.7
Tavernarakis, N.8
Kroemer, G.9
-
48
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E., Maiuri M.C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J.M., Carnuccio R., Moll U.M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., and Kroemer G. Regulation of autophagy by cytoplasmic p53. Nat. Cell. Biol. 10 (2008) 676-687
-
(2008)
Nat. Cell. Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
Criollo, A.7
Morselli, E.8
Zhu, C.9
Harper, F.10
Nannmark, U.11
Samara, C.12
Pinton, P.13
Vicencio, J.M.14
Carnuccio, R.15
Moll, U.M.16
Madeo, F.17
Paterlini-Brechot, P.18
Rizzuto, R.19
Szabadkai, G.20
Pierron, G.21
Blomgren, K.22
Tavernarakis, N.23
Codogno, P.24
Cecconi, F.25
Kroemer, G.26
more..
-
49
-
-
53549122987
-
The effects of p53 on whole organism longevity are mediated by autophagy
-
Tavernarakis N., Pasparaki A., Tasdemir E., Maiuri M.C., and Kroemer G. The effects of p53 on whole organism longevity are mediated by autophagy. Autophagy 4 (2008) 870-873
-
(2008)
Autophagy
, vol.4
, pp. 870-873
-
-
Tavernarakis, N.1
Pasparaki, A.2
Tasdemir, E.3
Maiuri, M.C.4
Kroemer, G.5
-
51
-
-
27644466759
-
Autophagy and signaling: their role in cell survival and cell death
-
Codogno P., and Meijer A.J. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ. 12 Suppl 2 (2005) 1509-1518
-
(2005)
Cell Death Differ.
, vol.12
, Issue.SUPPL. 2
, pp. 1509-1518
-
-
Codogno, P.1
Meijer, A.J.2
-
52
-
-
34548421950
-
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
-
Kang C., You Y.J., and Avery L. Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 21 (2007) 2161-2171
-
(2007)
Genes Dev.
, vol.21
, pp. 2161-2171
-
-
Kang, C.1
You, Y.J.2
Avery, L.3
-
53
-
-
34250819292
-
Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants
-
Gomez T.A., and Clarke S.G. Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants. Autophagy 3 (2007) 357-359
-
(2007)
Autophagy
, vol.3
, pp. 357-359
-
-
Gomez, T.A.1
Clarke, S.G.2
-
54
-
-
34247379570
-
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans
-
Toth M.L., Simon P., Kovacs A.L., and Vellai T. Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J. Cell Sci. 120 (2007) 1134-1141
-
(2007)
J. Cell Sci.
, vol.120
, pp. 1134-1141
-
-
Toth, M.L.1
Simon, P.2
Kovacs, A.L.3
Vellai, T.4
-
55
-
-
34248998801
-
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
-
Maiuri M.C., Le Toumelin G., Criollo A., Rain J.C., Gautier F., Juin P., Tasdemir E., Pierron G., Troulinaki K., Tavernarakis N., Hickman J.A., Geneste O., and Kroemer G. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 26 (2007) 2527-2539
-
(2007)
EMBO J.
, vol.26
, pp. 2527-2539
-
-
Maiuri, M.C.1
Le Toumelin, G.2
Criollo, A.3
Rain, J.C.4
Gautier, F.5
Juin, P.6
Tasdemir, E.7
Pierron, G.8
Troulinaki, K.9
Tavernarakis, N.10
Hickman, J.A.11
Geneste, O.12
Kroemer, G.13
-
58
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi Y., Coppola D., Matsushita N., Cualing H.D., Sun M., Sato Y., Liang C., Jung J.U., Cheng J.Q., Mul J.J., Pledger W.J., and Wang H.G. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9 (2007) 1142-1151
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
Coppola, D.2
Matsushita, N.3
Cualing, H.D.4
Sun, M.5
Sato, Y.6
Liang, C.7
Jung, J.U.8
Cheng, J.Q.9
Mul, J.J.10
Pledger, W.J.11
Wang, H.G.12
-
59
-
-
48249108314
-
Tumor suppression by autophagy through the management of metabolic stress
-
Jin S., and White E. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 4 (2008) 563-566
-
(2008)
Autophagy
, vol.4
, pp. 563-566
-
-
Jin, S.1
White, E.2
-
60
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S., Tassa A., Qu X., Garuti R., Liang X.H., Mizushima N., Packer M., Schneider M.D., and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122 (2005) 927-939
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
61
-
-
0035929650
-
The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
-
Arico S., Petiot A., Bauvy C., Dubbelhuis P.F., Meijer A.J., Codogno P., and Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276 (2001) 35243-35246
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35243-35246
-
-
Arico, S.1
Petiot, A.2
Bauvy, C.3
Dubbelhuis, P.F.4
Meijer, A.J.5
Codogno, P.6
Ogier-Denis, E.7
-
62
-
-
2442482810
-
Autophagy as a cell death and tumor suppressor mechanism
-
Gozuacik D., and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23 (2004) 2891-2906
-
(2004)
Oncogene
, vol.23
, pp. 2891-2906
-
-
Gozuacik, D.1
Kimchi, A.2
-
63
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X., Yu J., Bhagat G., Furuya N., Hibshoosh H., Troxel A., Rosen J., Eskelinen E.L., Mizushima N., Ohsumi Y., Cattoretti G., and Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112 (2003) 1809-1820
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.L.8
Mizushima, N.9
Ohsumi, Y.10
Cattoretti, G.11
Levine, B.12
-
64
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z., Jin S., Yang C., Levine A.J., and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15077-15082
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
65
-
-
33846204370
-
UVRAG: a new player in autophagy and tumor cell growth
-
Liang C., Feng P., Ku B., Oh B.H., and Jung J.U. UVRAG: a new player in autophagy and tumor cell growth. Autophagy 3 (2007) 69-71
-
(2007)
Autophagy
, vol.3
, pp. 69-71
-
-
Liang, C.1
Feng, P.2
Ku, B.3
Oh, B.H.4
Jung, J.U.5
-
66
-
-
33645944960
-
Autophagy and cancer therapy
-
Kondo Y., and Kondo S. Autophagy and cancer therapy. Autophagy 2 (2006) 85-90
-
(2006)
Autophagy
, vol.2
, pp. 85-90
-
-
Kondo, Y.1
Kondo, S.2
-
67
-
-
39049194057
-
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
-
Furuya N., Yu J., Byfield M., Pattingre S., and Levine B. The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1 (2005) 46-52
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Pattingre, S.4
Levine, B.5
-
68
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P.R., Gasco M., Garrone O., Crook T., and Ryan K.M. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126 (2006) 121-134
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
Gasco, M.7
Garrone, O.8
Crook, T.9
Ryan, K.M.10
-
69
-
-
33947715833
-
p53, Autophagy and tumor suppression
-
Jin S. p53, Autophagy and tumor suppression. Autophagy 1 (2005) 171-173
-
(2005)
Autophagy
, vol.1
, pp. 171-173
-
-
Jin, S.1
-
70
-
-
39749114348
-
Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans
-
Khan L.A., Yamanaka T., and Nukina N. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 368 (2008) 729-735
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.368
, pp. 729-735
-
-
Khan, L.A.1
Yamanaka, T.2
Nukina, N.3
-
71
-
-
33846210657
-
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans
-
Jia K., Hart A.C., and Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 3 (2007) 21-25
-
(2007)
Autophagy
, vol.3
, pp. 21-25
-
-
Jia, K.1
Hart, A.C.2
Levine, B.3
-
72
-
-
35848955910
-
Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans
-
Florez-McClure M.L., Hohsfield L.A., Fonte G., Bealor M.T., and Link C.D. Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans. Autophagy 3 (2007) 569-580
-
(2007)
Autophagy
, vol.3
, pp. 569-580
-
-
Florez-McClure, M.L.1
Hohsfield, L.A.2
Fonte, G.3
Bealor, M.T.4
Link, C.D.5
-
73
-
-
25844487226
-
Diseases of unstable repeat expansion: mechanisms and common principles
-
Gatchel J.R., and Zoghbi H.Y. Diseases of unstable repeat expansion: mechanisms and common principles. Nat. Rev. Genet. 6 (2005) 743-755
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 743-755
-
-
Gatchel, J.R.1
Zoghbi, H.Y.2
-
74
-
-
37849042536
-
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
-
Sarkar S., Krishna G., Imarisio S., Saiki S., O'Kane C.J., and Rubinsztein D.C. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum. Mol. Genet. 17 (2008) 170-178
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 170-178
-
-
Sarkar, S.1
Krishna, G.2
Imarisio, S.3
Saiki, S.4
O'Kane, C.J.5
Rubinsztein, D.C.6
-
75
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
Nixon R.A. Autophagy, amyloidogenesis and Alzheimer disease. J. Cell Sci. 120 (2007) 4081-4091
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
76
-
-
26444515364
-
Autophagy and its possible roles in nervous system diseases, damage and repair
-
Rubinsztein D.C., DiFiglia M., Heintz N., Nixon R.A., Qin Z.H., Ravikumar B., Stefanis L., and Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1 (2005) 11-22
-
(2005)
Autophagy
, vol.1
, pp. 11-22
-
-
Rubinsztein, D.C.1
DiFiglia, M.2
Heintz, N.3
Nixon, R.A.4
Qin, Z.H.5
Ravikumar, B.6
Stefanis, L.7
Tolkovsky, A.8
-
77
-
-
26844531363
-
Maturation of autophagic vacuoles in mammalian cells
-
Eskelinen E.L. Maturation of autophagic vacuoles in mammalian cells. Autophagy 1 (2005) 1-10
-
(2005)
Autophagy
, vol.1
, pp. 1-10
-
-
Eskelinen, E.L.1
-
78
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford F., Masliah E., Britschgi M., Lucin K., Narasimhan R., Jaeger P.A., Small S., Spencer B., Rockenstein E., Levine B., and Wyss-Coray T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 118 (2008) 2190-2199
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
Wyss-Coray, T.11
-
79
-
-
0034703336
-
TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease
-
Shashidharan P., Good P.F., Hsu A., Perl D.P., Brin M.F., and Olanow C.W. TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease. Brain Res. 877 (2000) 379-381
-
(2000)
Brain Res.
, vol.877
, pp. 379-381
-
-
Shashidharan, P.1
Good, P.F.2
Hsu, A.3
Perl, D.P.4
Brin, M.F.5
Olanow, C.W.6
-
80
-
-
38649084391
-
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
-
Hamamichi S., Rivas R.N., Knight A.L., Cao S., Caldwell K.A., and Caldwell G.A. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 728-733
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 728-733
-
-
Hamamichi, S.1
Rivas, R.N.2
Knight, A.L.3
Cao, S.4
Caldwell, K.A.5
Caldwell, G.A.6
-
81
-
-
0036846119
-
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation
-
McLean P.J., Kawamata H., Shariff S., Hewett J., Sharma N., Ueda K., Breakefield X.O., and Hyman B.T. TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. J. Neurochem. 83 (2002) 846-854
-
(2002)
J. Neurochem.
, vol.83
, pp. 846-854
-
-
McLean, P.J.1
Kawamata, H.2
Shariff, S.3
Hewett, J.4
Sharma, N.5
Ueda, K.6
Breakefield, X.O.7
Hyman, B.T.8
-
82
-
-
41949097891
-
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging
-
van Ham T.J., Thijssen K.L., Breitling R., Hofstra R.M., Plasterk R.H., and Nollen E.A. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet. 4 (2008) e1000027
-
(2008)
PLoS Genet.
, vol.4
-
-
van Ham, T.J.1
Thijssen, K.L.2
Breitling, R.3
Hofstra, R.M.4
Plasterk, R.H.5
Nollen, E.A.6
-
83
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper A.A., Gitler A.D., Cashikar A., Haynes C.M., Hill K.J., Bhullar B., Liu K., Xu K., Strathearn K.E., Liu F., Cao S., Caldwell K.A., Caldwell G.A., Marsischky G., Kolodner R.D., Labaer J., Rochet J.C., Bonini N.M., and Lindquist S. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313 (2006) 324-328
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
Labaer, J.16
Rochet, J.C.17
Bonini, N.M.18
Lindquist, S.19
-
84
-
-
27944506923
-
A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
-
Springer W., Hoppe T., Schmidt E., and Baumeister R. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 14 (2005) 3407-3423
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 3407-3423
-
-
Springer, W.1
Hoppe, T.2
Schmidt, E.3
Baumeister, R.4
-
85
-
-
37849007550
-
Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?
-
Kabashi E., Valdmanis P.N., Dion P., and Rouleau G.A. Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?. Ann. Neurol. 62 (2007) 553-559
-
(2007)
Ann. Neurol.
, vol.62
, pp. 553-559
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Rouleau, G.A.4
-
86
-
-
0034772838
-
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans
-
Oeda T., Shimohama S., Kitagawa N., Kohno R., Imura T., Shibasaki H., and Ishii N. Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum. Mol. Genet. 10 (2001) 2013-2023
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2013-2023
-
-
Oeda, T.1
Shimohama, S.2
Kitagawa, N.3
Kohno, R.4
Imura, T.5
Shibasaki, H.6
Ishii, N.7
-
87
-
-
43949102061
-
Autophagy and amyotrophic lateral sclerosis: the multiple roles of lithium
-
Fornai F., Longone P., Ferrucci M., Lenzi P., Isidoro C., Ruggieri S., and Paparelli A. Autophagy and amyotrophic lateral sclerosis: the multiple roles of lithium. Autophagy 4 (2008) 527-530
-
(2008)
Autophagy
, vol.4
, pp. 527-530
-
-
Fornai, F.1
Longone, P.2
Ferrucci, M.3
Lenzi, P.4
Isidoro, C.5
Ruggieri, S.6
Paparelli, A.7
-
88
-
-
41149124406
-
Lithium delays progression of amyotrophic lateral sclerosis
-
Fornai F., Longone P., Cafaro L., Kastsiuchenka O., Ferrucci M., Manca M.L., Lazzeri G., Spalloni A., Bellio N., Lenzi P., Modugno N., Siciliano G., Isidoro C., Murri L., Ruggieri S., and Paparelli A. Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 2052-2057
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 2052-2057
-
-
Fornai, F.1
Longone, P.2
Cafaro, L.3
Kastsiuchenka, O.4
Ferrucci, M.5
Manca, M.L.6
Lazzeri, G.7
Spalloni, A.8
Bellio, N.9
Lenzi, P.10
Modugno, N.11
Siciliano, G.12
Isidoro, C.13
Murri, L.14
Ruggieri, S.15
Paparelli, A.16
-
89
-
-
25444483066
-
Lithium induces autophagy by inhibiting inositol monophosphatase
-
Sarkar S., Floto R.A., Berger Z., Imarisio S., Cordenier A., Pasco M., Cook L.J., and Rubinsztein D.C. Lithium induces autophagy by inhibiting inositol monophosphatase. J. Cell Biol. 170 (2005) 1101-1111
-
(2005)
J. Cell Biol.
, vol.170
, pp. 1101-1111
-
-
Sarkar, S.1
Floto, R.A.2
Berger, Z.3
Imarisio, S.4
Cordenier, A.5
Pasco, M.6
Cook, L.J.7
Rubinsztein, D.C.8
-
90
-
-
0036023937
-
Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?
-
Syntichaki P., and Tavernarakis N. Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?. EMBO Rep. 3 (2002) 604-609
-
(2002)
EMBO Rep.
, vol.3
, pp. 604-609
-
-
Syntichaki, P.1
Tavernarakis, N.2
-
91
-
-
0043238675
-
The biochemistry of neuronal necrosis: rogue biology?
-
Syntichaki P., and Tavernarakis N. The biochemistry of neuronal necrosis: rogue biology?. Nat. Rev. Neurosci. 4 (2003) 672-684
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 672-684
-
-
Syntichaki, P.1
Tavernarakis, N.2
-
92
-
-
0035960074
-
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum
-
Xu K., Tavernarakis N., and Driscoll M. Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron 31 (2001) 957-971
-
(2001)
Neuron
, vol.31
, pp. 957-971
-
-
Xu, K.1
Tavernarakis, N.2
Driscoll, M.3
-
93
-
-
37349037902
-
Autophagy is required for necrotic cell death in Caenorhabditis elegans
-
Samara C., Syntichaki P., and Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 15 (2008) 105-112
-
(2008)
Cell Death Differ.
, vol.15
, pp. 105-112
-
-
Samara, C.1
Syntichaki, P.2
Tavernarakis, N.3
-
94
-
-
0141539596
-
Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans
-
Samara C., and Tavernarakis N. Calcium-dependent and aspartyl proteases in neurodegeneration and ageing in C. elegans. Ageing Res. Rev. 2 (2003) 451-471
-
(2003)
Ageing Res. Rev.
, vol.2
, pp. 451-471
-
-
Samara, C.1
Tavernarakis, N.2
-
95
-
-
33846226521
-
The roles of autophagy in cerebral ischemia
-
Adhami F., Schloemer A., and Kuan C.Y. The roles of autophagy in cerebral ischemia. Autophagy 3 (2007) 42-44
-
(2007)
Autophagy
, vol.3
, pp. 42-44
-
-
Adhami, F.1
Schloemer, A.2
Kuan, C.Y.3
-
96
-
-
58149089765
-
Autophagy protects against hypoxic injury in C. elegans
-
Samokhvalov V., Scott B.A., and Crowder C.M. Autophagy protects against hypoxic injury in C. elegans. Autophagy 4 (2008) 1034-1041
-
(2008)
Autophagy
, vol.4
, pp. 1034-1041
-
-
Samokhvalov, V.1
Scott, B.A.2
Crowder, C.M.3
-
97
-
-
20344387475
-
Autophagy: dual roles in life and death?
-
Baehrecke E.H. Autophagy: dual roles in life and death?. Nat. Rev. Mol. Cell Biol. 6 (2005) 505-510
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
98
-
-
33645916698
-
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations
-
Sarkar S., and Rubinsztein D.C. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy 2 (2006) 132-134
-
(2006)
Autophagy
, vol.2
, pp. 132-134
-
-
Sarkar, S.1
Rubinsztein, D.C.2
-
99
-
-
33746487396
-
Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans
-
Khan L.A., Bauer P.O., Miyazaki H., Lindenberg K.S., Landwehrmeyer B.G., and Nukina N. Expanded polyglutamines impair synaptic transmission and ubiquitin-proteasome system in Caenorhabditis elegans. J. Neurochem. 98 (2006) 576-587
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(2006)
J. Neurochem.
, vol.98
, pp. 576-587
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Khan, L.A.1
Bauer, P.O.2
Miyazaki, H.3
Lindenberg, K.S.4
Landwehrmeyer, B.G.5
Nukina, N.6
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