Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 62, Issue 9, 2007, Pages 951-959

  Arum, Oge ^a,b   Johnson, Thomas E ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; CELL NUCLEUS; CEP 1 GENE; DAF 16 GENE; DNA DAMAGE; DROSOPHILA MELANOGASTER; GENE; GENE EXPRESSION; GENE FUNCTION; HEAT TOLERANCE; HUS 1 GENE; LIFESPAN; LONGEVITY; NONHUMAN; ORTHOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGERIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SURVIVAL TIME; ULTRAVIOLET RADIATION;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 34948911093     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/62.9.951     Document Type: Article

References (47)

1. Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 2005;120:497-512.
2. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002;415:45-53.
3. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, et al. Modulation of mammalian lifespan by the short isoform of p53. Genes Dev. 2004;18:306-319.
4. Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol. 2005;15:2063-2068.
5. Bonafe M, Olivieri F, Mari D, Baggio G, Mattace R, Sansoni P, et al. p53 variants predisposing to cancer are present in healthy centenarians. Am J Hum Genet. 1999;64:292-295.
6. van Heemst D, Mooijaart SP, Beekman M, Schreuder J, de Craen AJ, Brandt BW, et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol. 2005;40:11-15.
7. Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, et al. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A. 2000;97:4291-4296.
8. Derry WB, Putzke AP, Rothman JH. Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science. 2001;294:591-595.
9. Schumacher B, Hofmann K, Boulton S, Gartner A. The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr Biol. 2001;11:1722-1727.
10. Campisi J. Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev. 2005;126:51-58.
11. Riddle DL, Albert PS, MacMorris MA. Interacting genes in nematode dauer larva formation. Nature. 1981;290:668-671.
12. Friedman DB, Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118:75-86.
13. Hofmann ER, Milstein S, Boulton SJ, Ye M, Hofmann JJ, Stergiou L, et al. Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol. 2002;12:1908-1918.
14. Brooks A, Lithgow GJ, Johnson TE. Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans. Science. 1994;263:668-671.
15. Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol. 2001;11:1975-1980.
16. Trent C, Tsung N, Horvitz HR. Egg-laying defective mutants of the nematode C. elegans. Genetics. 1983;104:619-647.
17. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell. 1986;44:817-829.
18. Hengartner MO, Ellis RE, Horvitz HR. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 1992;356:494-499.
19. Hekimi S, Boutis P, Lakowski B. Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Genetics. 1995;141:1351-1364.
20. Hartman PS, Herman RK. Radiation-sensitive mutants of C. elegans. Genetics. 1982;102:159-178.
21. Hodgkin JA, Horvitz HR, Brenner S. Nondisjunction mutants of the nematode C. elegans. Genetics. 1979;91:67-94.
22. Ahmed S, Hodgkin JA. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature. 2000;403:159-164.
23. Degtyareva NP, Greenwell P, Hofmann ER, Hengartner MO, Zhang L, Culotti JG, et al. Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. Proc Natl Acad Sci U S A. 2002;99:2158-2163.
24. Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001;410:227-230.
25. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77:71-94.
26. Sulston J, Hodgkin J. Methods. In: Wood W, ed. The Nematode Caenorhabditis elegans. Plainview, NY: Cold Spring Harbor Press; 1988:587-606.
27. Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, Ahringer J. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature. 2000;408:325-330.
28. Golden JW, Riddle DL. A pheromone-induced developmental switch in Caenorhabditis elegans: temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci USA. 1984;81:819-823.
29. Wang C, Li Q, Redden DT, Weindruch R, Allison DB. Statistical methods for testing effects on "maximum lifespan." Mech Ageing Dev. 2004;125:629-632.
30. Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics. 2002;161:1101-1112.
31. Johnson TE, Lithgow GJ, Murakami S. Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J Gerontol A Biol Sci Med Sci. 1996;51A:B392-B395.
32. Medawar PB. An Unsolved Problem in Biology. London: H. K. Lewis; 1952.
33. Kirkwood TB. Understanding the odd science of aging. Cell. 2005;120:437-447.
34. McElwee J, Bubb K, Thomas JH. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell. 2003;2:111-121.
35. Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003;424:277-283.
36. Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004;125:811-826.
37. Lithgow GJ. Invertebrate gerontology: the age mutations of Caenorhabditis elegans. Bioessays. 1996;18:809-815.
38. Walker GA, Walker DW, Lithgow GJ. Genes that determine both thermotolerance and rate of aging in Caenorhabditis elegans. Ann N Y Acad Sci. 1998;851:444-449.
39. Walker GA, Walker DW, Lithgow GJ. A relationship between thermotolerance and longevity in Caenorhabditis elegans. J Investig Dermatol Symp Proc. 1998;3:6-10.
40. Munoz M, Riddle DL. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics. 2003;163:171-180.
41. De Castro E, De Castro S, Johnson TE. Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone. Free Radic Biol Med. 2004;37:139-145.
42. Miwa S, Riyahi K, Partridge L, Brand MD. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci. 2004;1019:388-391.
43. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genom. 2003;16:29-37.
44. Sengupta S, Harris CC. p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol. 2005;6:44-55.
45. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
46. Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun. 2005;331:851-858.
47. Sun Y. p53 and its downstream proteins as molecular targets of cancer. Mol Carcinog. 2006;45:409-415.