PRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda

BMC Clinical Pathology

Volumn 9, Issue 1, 2009, Pages

  Kalungi, Sam ^a,b   Steine, Solrun J ^a   Wabinga, Henry ^b   Bostad, Leif ^a,c   Molven, Anders ^a,c  

^a UNIVERSITY OF BERGEN   (Norway)

^b MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P107; PROTEIN P130; RETINOBLASTOMA PROTEIN;

ADOLESCENT; ARTICLE; BURKITT LYMPHOMA; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL CYCLE; CELLULAR DISTRIBUTION; CHILD; DNA SEQUENCE; FEMALE; GENE; GENE MUTATION; GROWTH DISORDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NUCLEAR LOCALIZATION SIGNAL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RBL2 GENE; SOMATIC MUTATION; UGANDA;

EID: 69549083204     PISSN: 14726890     EISSN: 14726890     Source Type: Journal    
DOI: 10.1186/1472-6890-9-6     Document Type: Article

References (37)

1. RB and cell cycle progression. C Giacinti A Giordano, Oncogene 2006 25 5220 5227 10.1038/sj.onc.1209615 16936740 (Pubitemid 44299080)
2. From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway. A Sun L Bagella S Tutton G Romano A Giordano, J Cell Biochem 2007 102 1400 1404 10.1002/jcb.21609 17979151 (Pubitemid 350223943)
3. Shared role of the pRB-related p130 and p107 proteins in limb development. D Cobrinik MH Lee G Hannon G Mulligan RT Bronson N Dyson E Harlow D Beach RA Weinberg T Jacks, Genes Dev 1996 10 1633 1644 10.1101/gad.10.13.1633 8682294
4. Targeted disruption of p107: functional overlap between p107 and Rb. MH Lee BO Williams G Mulligan S Mukai RT Bronson N Dyson E Harlow T Jacks, Genes Dev 1996 10 1621 1632 10.1101/gad.10.13.1621 8682293
5. Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression. PA Hamel RA Phillips M Muncaster BL Gallie, Faseb J 1993 7 846 854 8344484
6. Alterations of pRb1-cyclin D1-cdk4/6-p16(INK4A) pathway in endometrial carcinogenesis. A Semczuk JA Jakowicki, Cancer Lett 2004 203 1 12 10.1016/j.canlet.2003.09.012 14670612 (Pubitemid 37506078)
7. Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside. TL Hocker MK Singh H Tsao, J Invest Dermatol 2008 128 2575 2595 10.1038/jid.2008.226 18927540
8. Regulation of cellular senescence by Rb2/p130. H Helmbold W Deppert W Bohn, Oncogene 2006 25 5257 5262 10.1038/sj.onc.1209613 16936745 (Pubitemid 44299085)
9. Genomic structure of the human retinoblastoma-related Rb2/p130 gene. A Baldi V Boccia PP Claudio A De Luca A Giordano, Proc Natl Acad Sci USA 1996 93 4629 4632 10.1073/pnas.93.10.4629 8643454 (Pubitemid 26163493)
10. The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. RS Yeung DW Bell JR Testa X Mayol A Baldi X Grana K Klinga-Levan AG Knudson A Giordano, Oncogene 1993 8 3465 3468 8247552
11. Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. A Chestukhin L Litovchick K Rudich JA DeCaprio, Mol Cell Biol 2002 22 453 468 10.1128/MCB.22.2.453-468.2002 11756542 (Pubitemid 34027491)
12. Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer. A Baldi V Esposito A De Luca Y Fu I Meoli GG Giordano M Caputi F Baldi A Giordano, Clin Cancer Res 1997 3 1691 1697 9815552
13. Expression of the retinoblastoma-related gene Rb2/p130 is downregulated in atypical endometrial hyperplasia and adenocarcinoma. T Susini D Massi M Paglierani V Masciullo G Scambia A Giordano G Amunni G Massi GL Taddei, Hum Pathol 2001 32 360 367 10.1053/hupa.2001.23514 11331952 (Pubitemid 32378297)
14. Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis. S Lazzi C Bellan G De Falco C Cinti F Ferrari A Nyongo PP Claudio GM Tosi R Vatti A Gloghini, Hum Pathol 2002 33 723 731 10.1053/hupa.2002.125372 12196924 (Pubitemid 34953352)
15. Expression of cell-cycle-associated proteins pRB2/p130 and p27kip in vulvar squamous cell carcinomas. A Zamparelli V Masciullo A Bovicelli D Santini G Ferrandina C Minimo P Terzano S Costa C Cinti C Ceccarelli, Hum Pathol 2001 32 4 9 10.1053/hupa.2001.20371 11172288 (Pubitemid 32150621)
16. Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications. G Russo A Zamparelli CM Howard C Minimo C Bellan G Carillo L Califano L Leoncini A Giordano PP Claudio, Clin Cancer Res 2005 11 3265 3273 10.1158/1078-0432.CCR- 04-2508 15867222 (Pubitemid 40627874)
17. Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance. M Massaro-Giordano G Baldi A De Luca A Baldi A Giordano, Clin Cancer Res 1999 5 1455 1458 10389932
18. Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother. MG Paggi A Giordano, Cancer Res 2001 61 4651 4654 11406530
19. Cell cycle regulators p105, p107, Rb2/p130, E2F4, p21CIP1/WAF1, cyclin A in predicting cervical intraepithelial neoplasia, high-risk human papillomavirus infections and their outcome in women screened in three new independent states of the former Soviet Union. R Santopietro I Shabalova N Petrovichev V Kozachenko T Zakharova J Pajanidi J Podistov G Chemeris L Sozaeva E Lipova, Cancer Epidemiol Biomarkers Prev 2006 15 1250 1256 10.1158/1055-9965.EPI-06-0086 16835319 (Pubitemid 44125277)
20. Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. T Sato A Tanigami K Yamakawa F Akiyama F Kasumi G Sakamoto Y Nakamura, Cancer Res 1990 50 7184 7189 1977515
21. Allelic loss of chromosomes 16q and 10q in human prostate cancer. BS Carter CM Ewing WS Ward BF Treiger TW Aalders JA Schalken JI Epstein WB Isaacs, Proc Natl Acad Sci USA 1990 87 8751 8755 10.1073/pnas.87.22.8751 1978938
22. Allelotype study of primary hepatocellular carcinoma. M Fujimori T Tokino O Hino T Kitagawa T Imamura E Okamoto M Mitsunobu T Ishikawa H Nakagama H Harada, Cancer Res 1991 51 89 93 1670995
23. Allelotype of human ovarian cancer. T Sato H Saito R Morita S Koi JH Lee Y Nakamura, Cancer Res 1991 51 5118 5122 1655245
24. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. K Helin K Holm A Niebuhr H Eiberg N Tommerup S Hougaard HS Poulsen M Spang-Thomsen P Norgaard, Proc Natl Acad Sci USA 1997 94 6933 6938 10.1073/pnas.94.13.6933 9192669 (Pubitemid 27281968)
25. Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. PP Claudio CM Howard Y Fu C Cinti L Califano P Micheli EW Mercer M Caputi A Giordano, Cancer Res 2000 60 8 12 10646842
26. Genetic alterations of the retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in and among Burkitt's lymphoma subtypes. C Cinti L Leoncini A Nyongo F Ferrari S Lazzi C Bellan R Vatti A Zamparelli G Cevenini GM Tosi, Am J Pathol 2000 156 751 760 10702389
27. Retinoblastoma-related geneRb2/p130 are rarely mutated in Burkitt's lymphoma from Brazil. CE Klumb EP Magluta LM Rezende AG Apa JF Alonso RC Maia, Am J Hematol 2007 82 238 239 10.1002/ajh.20749 16955460 (Pubitemid 46363794)
28. Lymphoreticular Neoplasms. DH Wright, Tumors in a Tropical Country: a Survey of Uganda 19641968 New York: Springer-Verlag, Templeton AC, 1973 271 297
29. Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited. MD Ogwang K Bhatia RJ Biggar SM Mbulaiteye, Int J Cancer 2008 123 2658 2663 10.1002/ijc.23800 18767045
30. Burkitt's lymphoma in Africa, a review of the epidemiology and etiology. J Orem EK Mbidde B Lambert S de Sanjose E Weiderpass, Afr Health Sci 2007 7 166 175 18052871
31. B-cell non-Hodgkin lymphomas in Uganda: an immunohistochemical appraisal on tissue microarray. LK Tumwine C Campidelli S Righi S Neda W Byarugaba SA Pileri, Hum Pathol 2008 39 817 823 10.1016/j.humpath.2007.10.025 18436278
32. Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: distinct mechanisms of cell growth control. L Leoncini C Bellan A Cossu PP Claudio S Lazzi C Cinti G Cevenini T Megha L Laurini P Luzi, Clin Cancer Res 1999 5 4065 4072 10632341
33. Cell cycle regulators p27 and pRb in lymphomas correlation with histology and proliferative activity. M Kiviniemi I Sauroja A Rajamaki K Punnonen KO Soderstrom E Salminen, Br J Cancer 2000 83 1161 1167 10.1054/bjoc.2000.1435 11027429
34. Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas. L Del Valle J Baehring C Lorenzana A Giordano K Khalili S Croul, Mol Pathol 2001 54 331 337 10.1136/mp.54.5.331 11577176 (Pubitemid 32928260)
35. Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma. PP Claudio A Zamparelli FU Garcia L Claudio G Ammirati A Farina A Bovicelli G Russo GG Giordano DE McGinnis, Clin Cancer Res 2002 8 1808 1815 12060621
36. Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma. H Huynh, Carcinogenesis 2004 25 1485 1494 10.1093/carcin/bgh154 15059924 (Pubitemid 39172079)
37. Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors. C Cinti PP Claudio CM Howard LM Neri Y Fu L Leoncini GM Tosi NM Maraldi A Giordano, Cancer Res 2000 60 383 389 10667591