In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2′-((dimethylamino)methyl)-4′-(fluoroalkoxy) phenylthio)benzenamine) for PET imaging of the serotonin transporter

Journal of Nuclear Medicine

Volumn 50, Issue 9, 2009, Pages 1509-1517

  Wang, Julie L ^a   Parhi, Ajit K ^a   Oya, Shunichi ^a   Lieberman, Brian ^a   Kung, Hank F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 HTT; 18F; Brain imaging; Radioligand; SERT

Indexed keywords

2 [2' [(DIMETHYLAMINO)METHYL] 4' 2 FLUOROETHOXY PHENYLTHIOL]BENZENAMINE F 18; 2 [2' [(DIMETHYLAMINO)METHYL] 4' 3 FLUOROPROPOXY PHENYLTHIOL]BENZENAMINE F 18; 2 [2' [(DIMETHYLAMINO)METHYL] 4' 4 FLUOROBUTOXY PHENYLTHIOL]BENZENAMINE F 18; 2 [2' [(DIMETHYLAMINO)METHYL] 4' 5 FLUOROPENTOXY PHENYLTHIOL]BENZENAMINE F 18; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CORPUS STRIATUM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MALE; MESENCEPHALON; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; THALAMUS;

ANILINE COMPOUNDS; ANIMALS; BRAIN; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SULFIDES; TISSUE DISTRIBUTION;

EID: 69449107821     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.060723     Document Type: Article

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