Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat

Journal of Comparative Neurology

Volumn 516, Issue 5, 2009, Pages 343-359

  Fischer, Wolfgang ^a   Nörenberg, Wolfgang ^a   Franke, Heike ^a   Schaefer, Michael ^a   Illes, Peter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Ca2+ microfluorimetry; Immunocytochemistry; P2X receptors; P2Y receptors; Rat cultured cortical neurons

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 4 AMINOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; FURA 2; MICROTUBULE ASSOCIATED PROTEIN 2; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X4 RECEPTOR; PURINERGIC P2X5 RECEPTOR; PURINERGIC P2X6 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; SURAMIN; URIDINE TRIPHOSPHATE; VOLTAGE GATED CALCIUM CHANNEL; AMINO ACID RECEPTOR STIMULATING AGENT; BIOCYTIN; CALCIUM; DRUG DERIVATIVE; FLUORESCENT DYE; GLUTAMATE RECEPTOR; LYSINE; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, RAT; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; GLIA CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MICROFLUOROMETRY; MIXED CELL CULTURE; NERVE CELL CULTURE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; WISTAR RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FLUOROMETRY; GENETICS; GLIA; METABOLISM; NERVE CELL; PHYSIOLOGY; PREGNANCY; STATISTICAL ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; EXCITATORY AMINO ACID AGONISTS; FEMALE; FLUORESCENT DYES; FLUOROMETRY; GAMMA-AMINOBUTYRIC ACID; LYSINE; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGLIA; NEURONS; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; RECEPTORS, PURINERGIC P2;

EID: 69449102510     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.22079     Document Type: Article

References (59)

1. Abbracchio MP, Burnstock G. 1994. Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64:445-475.
2. Abbracchio MP, Ceruti S. 2006. Roles of P2 receptors in glial cells: focus on astrocytes. Purinergic Signal 2:595-604.
3. Abbracchio MP, Burnstock G, Boeynaems J-M, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. 2006. International union of pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281-341.
4. Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD. 2008. What is the role of astrocyte calcium in neurophysiology? Neuron 59:932-946.
5. 7 receptors in adult rat cerebrocortical nerve terminals. FEBS Letters 582:3948-3953.
6. 7 receptor function and immunoreactivity in neurons. Trends Neurosci 29:257-262.
7. Araque A, Carmignoto G, Haydon PG. 2001. Dynamic signaling between astrocytes and neurons. Annu Rev Physiol 63:795-813.
8. Burnstock G. 2007. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87:659-797.
9. Burnstock G. 2008. Purinergic signaling and disorders of the central nervous system. Nat Rev Drug Discov 7:575-590.
10. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495-2507.
11. 7 receptors are targeted to presynaptic terminals in the central and peripheral nervous system. J Neurosci 21:7143-7152.
12. 7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci 23:1320-1328.
13. Fischer W, Krügel U. 2007. P2Y receptors: focus on structural, pharmacological and functional aspects in the brain. Curr Med Chem 14: 2429-2455.
14. 2+ influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry. Eur J Pharmacol 438:53-62.
15. 2+ response to AMPA in cultured rat cortical GABAergic nonpyramidal neurons. Alcohol Alcoholism 38:394-399.
16. Fischer W, Franke H, Appelt K, Illes P. 2006. Characterization of P2X/Y receptors in mixed neuronal-glial cell cultures. 47th Spring Meeting in the German Society of Experimental and Clinical Pharmacology and Toxicology, Mainz, 04.-06.04.2006. Naunyn-Schmiedeberg's Arch Pharmacol 372(Suppl 1):R41.
17. 2+ by P2X and P2Y receptor subtypes in cultured cortical astroglia of the rat. Neuroscience doi 10.1016/j.neuroscience.2009.02.026.
18. Franke H, Illes P. 2006. Involvement of P2 receptors in the growth and survival of neurons in the CNS. Pharmacol Ther 109:297-324.
19. Fumagalli M, Brambilla R, D'Ambrosi N, Volonté C, Matteoli M, Verderio C, Abbracchio MP. 2003. Nucleotide-mediated calcium signaling in rat cortical astrocytes: role of P2X and P2Y receptors. Glia 43:218-230.
20. Haydon PG, Carmignoto G. 2006. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86:1009-1031.
21. Illes P, Ribeiro JA. 2004. Molecular physiology of P2 receptors in the central nervous system. Eur J Pharmacol 483:5-17.
22. 2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol 407:11-32.
23. Khakh BS, North RA. 2006. P2X receptors as cell-surface ATP sensors in health and disease. Nature 442:527-532.
24. 1-histamine receptors triggers cytoplasmic calcium signaling in cerebellar Purkinje neurons. Neuroscience 73:643-647.
25. 2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes. Life Sci 72:431-442.
26. 7 receptor agonist 2′-3′-O-(4-benzoylbenzoyl)-ATP. J Neurosci 24:7128-7139.
27. Lalo U, Voitenko N, Kostyuk P. 1998. Iono- and metabotropically induced purinergic calcium signaling in rat neocortical neurons. Brain Res 799:285-291.
28. Leê KT, Villeneuve P, Ramjaun AR, McPherson PS, Beaudet A, Séguéla P. 1998. Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors. Neuroscience 83:177-190.
29. 2 receptor mRNA in the cerebellum. Methods Mol Biol 326:151-162.
30. 7 receptor subtypes. Br J Pharmacol 135:1616-1626.
31. 7 receptor. Neuroscience 151:361-373.
32. 7 receptors in rat brain: presence in synaptic terminals and granule cells. Neurochem Res 28:1597-1605.
33. 2+ mobilizing mechanisms. Neuropharmacology 33:1-13.
34. 1 purinergic receptor in the human brain: striking neuronal localization. J Comp Neurol 421:374-384.
35. 1 purinergic receptor in neurons and glial cells of the central nervous system. Brain Res Mol Brain Res 78:50-58.
36. Nedergaard M. 1994. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 263:1768-1771.
37. Ni Y, Malarkey EB, Parpura V. 2007. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons. J Neurochem 103:1273-1284.
38. Nörenberg W, Illes P. 2000. Neuronal P2X receptors: localization and functional properties. Naunyn Schmiedeberg's Arch Pharmacol 362:324-339.
39. North RA. 2002. Molecular physiology of P2X receptors. Physiol Rev 82:1013-1067.
40. Parekh AB, Putney JW Jr. 2005. Store-operated calcium channels. Physiol Rev 85:757-810.
41. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol Rev 50:413-592.
42. 4 receptors in the rat hippocampus. J Neurosci 25:6286-6295.
43. 1 receptors may depend on the developmental stage of cultured rat striatal neurons. J Cell Physiol 209:81-93.
44. Rubio ME, Soto F. 2001. Distinct localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci 21:641-653.
45. 7 receptor expression in rodent brain. J Neurosci 24:6307-6314.
46. 4: an ATP-activated ionotropic receptor cloned from rat brain. Proc Natl Acad Sci U S A 93:3684-3688.
47. 7 receptors in the nervous system. Prog Neurobiol 78:327-346.
48. 7). Science 272:735-738.
49. Verkhratsky A. 2006. Patching the glia reveals the functional organisation of the brain. Pflügers Arch Eur J Physiol 453:411-420.
50. Verkhratsky A, Orkand RK, Kettenmann H. 1998. Glial calcium: homeostasis and signaling function. Physiol Rev 78:99-141.
51. 7 receptor. J Physiol 519:335-346.
52. Volterra A, Meldolesi J. 2005. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 6:626-640.
53. von Kügelgen I. 2006. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415-432.
54. Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, Elde R. 1996. Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci U S A 93:8063-8067.
55. 2+ ions. Br J Pharmacol 140:1177-1186.
56. Wirkner K, Köfalvi A, Fischer W, Günther A, Franke H, Gröger-Arndt H, Nörenberg W, Madarász E, Vizi ES, Schneider D, Sperlágh B, Illes P. 2005. Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. J Neurochem 95:1421-1437.
57. Wirkner K, Günther A, Weber M, Guzman SJ, Krause T, Fuchs J, Köles L, Nörenberg W, Illes P. 2007. Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation. Cereb Cortex 17:621-631.
58. 7 receptor mRNA in the rat brain. Brain Res 1194:45-55.
59. Zeng JW, Liu XH, He WJ, Du L, Zhang JH, Wu XG, Ruan HZ. 2008. Inhibition of ATP-Induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes. Pharmacology 82:257-263.