Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

Neuroscience

Volumn 151, Issue 2, 2008, Pages 361-373

  Marin Garcia P ^a   Sanchez Nogueiro J ^a   Gomez Villafuertes R ^a,b   Leon D ^a   Miras Portugal, M T ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

ATP; BBG; BzATP; KN 62; P2X7 receptor; synaptosomes

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2',3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; BRILLIANT BLUE; BRILLIANT BLUE G; PURINERGIC P2X7 RECEPTOR; SURAMIN; UNCLASSIFIED DRUG; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; IC 50; IMMUNOHISTOCHEMISTRY; MESENCEPHALON; MICROFLUOROMETRY; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; SYNAPSE; SYNAPTOSOME; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROMETRY; IMMUNOHISTOCHEMISTRY; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRESYNAPTIC TERMINALS; RECEPTORS, PURINERGIC P2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNAPTOSOMES;

EID: 37849017425     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.10.038     Document Type: Article

References (42)

1. Abbracchio M., and Burnstock G. Purinoceptors: are there families of P2X and P2Y purinoceptors?. Pharmacol Ther 64 (1994) 445-475
2. 7 receptor function and immunoreactivity in neurons. Trends Neurosci 29 (2006) 257-262
3. 7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase. J Neurosci 22 (2002) 5938-5945
4. 7 in microglial proliferation. J Neurochem 99 (2006) 745-758
5. Burnstock G. Purinergic signalling: therapeutic potential. An R Acad Nac Farm 71 (2005) 283-319
6. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15 (1993) 532-537
7. 7 receptor immunoreactivity in distinct subsets of synaptic terminals in the ventral horn of rat lumbar spinal cord. Brain Res 1020 (2004) 53-61
8. 7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide. J Immunol 167 (2001) 1871-1876
9. 7 receptors are targeted to presynaptic terminals in the central and peripheral nervous system. J Neurosci 21 (2001) 7143-7152
10. 7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151 (2007) 571-579
11. Dunkley P.R., Jarvie P.E., Heath J.W., Kidd G.J., and Rostas J.A. A rapid method for isolation of synaptosomes on Percoll gradients. Brain Res 372 (1986) 115-129
12. 7 receptor-mRNA and -protein in the mouse retina: changes during retinal degeneration in BALBCrds mice. Neurochem Int 47 (2005) 235-242
13. Franke H., and Illes P. Involvement of P2 receptors in the growth and survival of neurons in the CNS. Pharmacol Ther 109 (2006) 197-324
14. Grynkiewicz G., Poeni M., and Tsien R.Y. A new generation of fluorescent calcium indicators with greatly improved fluorescence properties. J Biol Chem 260 (1985) 3440-3450
15. Hervás C., Pérez-Sen R., and Miras-Portugal M.T. Coexpression of functional P2X and P2Y nucleotide receptors in single cerebellar granule cells. J Neurosci Res 73 (2003) 384-399
16. Hervás C., Pérez-Sen R., and Miras-Portugal M.T. Presence of diverse functional P2X receptors in rat cerebellar synaptic terminals. Biochem Pharmacol 70 (2005) 770-785
17. 7 receptors antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther 319 (2006) 1376-1385
18. Ireland M.F., Noakes P.G., and Bellingham M.C. P2X7-like receptor subunits enhance excitatory synaptic transmission at central synapses by presynaptic mechanisms. Neuroscience 128 (2004) 269-280
19. 7 receptors. Mol Pharmacol 58 (2000) 82-88
20. 7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol 17 (2003) 1356-1367
21. 7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168 (2002) 6436-6445
22. 7 receptors induce calcium/calmodulin-dependent protein kinase II phosphorylation in cerebellar granule neurons. Eur J Neurosci 23 (2006) 2999-3013
23. -ΔΔCT method. Methods 25 (2001) 402-408
24. 7 receptor subtypes. Br J Pharmacol 135 (2002) 1616-1626
25. 7 receptors in rat brain: presence in synaptic terminals and granule cells. Neurochem Res 28 (2003) 1597-1605
26. 7-like receptors at the neuromuscular junction. Brain Res 1034 (2005) 40-50
27. North R.A. Molecular physiology of P2X receptors. Physiol Rev 82 (2002) 1013-1067
28. North R.A., and Surprenant A. Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40 (2002) 563-580
29. 7 receptors exert a permissive role on the activation of release-enhancing presynaptic α7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals. Neuropharmacology 50 (2006) 705-713
30. Pintor J., and Miras-Portugal M.T. A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat midbrain synaptosomes. Br J Pharmacol 115 (1995) 895-902
31. 7 receptors in submandibular ductal cells. Cell Signal 15 (2003) 927-935
32. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50 (1998) 413-492
33. Roberts J.A., Vial C., Digby H.R., Agboh K.C., Wen H., Atterbury-Thomas A., and Evans R.J. Molecular properties of P2X receptors. Plugers Arch Eur J Physiol 452 (2006) 486-500
34. 7 knockout mice. FEBS Lett 579 (2005) 3783-3788
35. 7 receptors. J Biol Chem 276 (2001) 125-132
36. 7 receptors in the regulation of neurotransmitter release in the rat hippocampus. J Neurochem 81 (2002) 1196-1211
37. 7 receptors in the nervous system. Prog Neurobiol 78 (2006) 327-346
38. 2+ signaling. J Neurosci 26 (2006) 1378-1385
39. Torres G.E., Egan T.M., and Voigt M.M. Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. J Biol Chem 274 (1999) 6653-6659
40. 7 receptor. Neuropharmacology 36 (1997) 1285-1294
41. 7 receptors in cerebrocortical cell cultures after in vitro ischemia. J Neurochem 95 (2005) 1421-1437
42. Xiang Z., and Burnstock G. Changes in expression of P2X purinoceptors in rat cerebellum during postnatal development. Brain Res Dev Brain Res 156 (2005) 147-157