Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates

Chemical Research in Toxicology

Volumn 9, Issue 2, 1996, Pages 517-526

  Tang, Wei ^a   Abbott, Frank S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPYL 2,4 PENTADIENOIC ACID; ANTICONVULSIVE AGENT; BETA GLUCURONIDASE; DRUG METABOLITE; GLUCURONIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; OXYTOCIN; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BILE; CONTROLLED STUDY; DISSOCIATION; DOSE RESPONSE; DRUG ACTIVATION; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG STRUCTURE; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; BILIARY TRACT; BIOTRANSFORMATION; FATTY ACIDS, UNSATURATED; GLUCURONATES; GLUCURONIDASE; GLUTATHIONE; MALE; MASS SPECTROMETRY; OXYTOCIN; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VALPROIC ACID;

ANIMALIA;

EID: 0029974584     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950120y     Document Type: Article

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