Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: Review of valproate hepatotoxicity in adults

Epilepsia

Volumn 40, Issue 7, 1999, Pages 1036-1040

  Konig S A ^a   Schenk, M ^a   Sick, C ^a   Holm, E ^a   Heubner, C ^a   Weiss, A ^a   Konig I ^a   Hehlmann, R ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adult patients; Friedreich's disease; Hepatotoxicity; Valproate

Indexed keywords

VALPROIC ACID;

ADULT; ARTICLE; AUTOPSY; BLEEDING TENDENCY; BRONCHOPNEUMONIA; CASE REPORT; DRUG EFFECT; DRUG WITHDRAWAL; FATALITY; FEMALE; FOCAL EPILEPSY; FRIEDREICH ATAXIA; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER FAILURE; PRIORITY JOURNAL;

EID: 0033022361     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1999.tb00814.x     Document Type: Article

References (24)

1. Bryant AE, Dreifuss FE. Valproic acid hepatic fatalities. III. US experience since 1986. Neurology 1996;46:465-9.
2. Dreifuss FE, Santilli N, Langer DH, Sweeny KP, Moline BA, Meander KB. Valproate acid hepatic fatalities: a retrospective review. Neurology 1987;37:397-400.
3. Dreifuss FE, Langer DH, Moline A, Maxwell E. Valproic acid fatalities. II. US experience since 1984. Neurology 1989;39:201-7.
4. Jeavons PM. Hepatotoxicity of antiepileptic drugs. In: Oxley J, Janz D, Meinardi H, eds. Antiepileptic therapy: chronic toxicity of antiepileptic drugs. New York: Raven Press, 1983:1-45.
5. König St A, Siemes H, Bläker F, et al. Severe hepatotoxicity during VPA therapy: an update and review of eight new fatalities. Epilepsia 1994;35:1005-15.
6. Scheffner D, König St A, Rauterberg-Ruland I, Kochen W, Hofmann WJ, Unkelbach ST. Fatal liver failure in 16 children with valproate therapy. Epilepsia 1988;29:530-42.
7. Harding BN, Egger J, Portmann B, Erdohazi M. Progressive neuronal degeneration of childhood with liver disease. Brain 1986; 109:181-206.
8. Helveston W, Hurd R, Uthman B, Wilder BJ. Abnormalities of glutathione peroxidase and glutathione reductase in four patients with Friedreich's disease. Mov Disord 1996;11:106-7.
9. Kay JDS, Hilton-Jones D, Hyman N. Valproate toxicity and ornithine carbamoyltransferase deficiency. Lancet 1986;II:1283-4.
10. König St A, Scheffner D, Rauterberg-Ruland I, et al. Tödliches Leberversagen bei einem altersgemäß entwickelten Jungen unter VPA-Monotherapie. Monatschr Kinderheilkd 1987;135:310-3.
11. Krähenbühl S, Mang G, Kupferschmidt H, Meier PJ, Krause M. Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal valproate-induced hepatotoxicity. Gut 1995;37:140-3.
12. Loyning Y, Johannessen SI, Ritland LS, Strandjord RE, Kloster R. Cases of serious/fatal hepatotoxicity due to valproate: recommended control scheme and preliminary results. In: Oxley J, Janz D, Meinardi H, eds Chronic toxicity of antiepileptic drugs. New York: Raven Press, 1983:47-70.
13. Rolles CJ. Hepatic injury with sodium valproate: a reappraisal with special reference to children. Br J Clin Pract 1983;727 (suppl.):72-6.
14. Spatz R, Kugler J, Pongratz D. Neuronale Ceroidlipofuszinose. In: Remschmidt H, Rentz R, Jungmann J, eds. Epilepsie 1980. Stuttgart: G. Thieme Verlag, 1982:186-92.
15. Stenzel E, Albani M, Doose H, Penin H, Scheffner D, Schmidt D. Valproat-Therapie und Lebertoxizität. Pädiatr Prax 1987;35:159-63.
16. Zäh W, Rengeling M, Rühl G, Hackenberg K. Akute Lebernekrose durch Valproinat. Dtsch Med Wochenschr 1985;110:956-9.
17. Graf WD, Oleinik OE, Glauser TA, Maertens P, Eder DN, Pippinger CE. Altered antioxidant enzyme activities in children with serious adverse experience related to valproic acid. Neuropediatrics 1998;29:195-201.
18. Eadie MJ, McKinnon GE, Dunstan PR, McLaughlin D, Dickinson RG. Valproate metabolism during hepatotoxicity associated with the drug. Q J Med 1990;284:1229-40.
19. Murphy MJ, Lyon LW, Taylor JW, Mittis G. Valproic acid associated pancreatitis in an adult. Lancet 1981;I:41-2.
20. Bell EA, Shaefer MS, Markin RS, et al. Treatment of valproic acid-associated hepatic failure with orthotopic liver transplantation. Ann Pharmacother 1992;26:18-21.
21. Ware S, Millward-Sadler GH. Acute liver failure associated with sodium valproate. Lancet 1980;II:1110-3.
22. Binek I, Hany A, Egloff B, Heer M. Akute tödliche Leberinsuffizienz unter Valproinsäure. Schweiz Med Wochenschr 1991;21: 228-33.
23. Caparros-Lefebvre D, Lecomte-Houcke M, Pruvot FR, Declerck N, Paris JC, Petit H. Unusual electronmicroscopic changes in valproate-associated liver failure. Lancet 1993;41:1604.
24. Le Bihan A. Fatal hepatic failure and sodium valproate. Lancet 1980;2:1298.