-
1
-
-
0008463096
-
Chemistry and biotransformation
-
Löscher W, ed, Birkhauser Verlag, Basel/Switzerland
-
Abbott FS and Anari MR (1999) Chemistry and biotransformation, in Valproate (Löscher W, ed) pp 47-75, Birkhauser Verlag, Basel/Switzerland.
-
(1999)
Valproate
, pp. 47-75
-
-
Abbott, F.S.1
Anari, M.R.2
-
2
-
-
0029095591
-
Distribution of unsaturated metabolites of valproate in human rat brain-pharmacologic relevance?
-
Adkinson K, Ojemann GA, Rapport RL, Dills RL, and Shen DD (1995) Distribution of unsaturated metabolites of valproate in human rat brain-pharmacologic relevance? Epilepsia 36:772-782.
-
(1995)
Epilepsia
, vol.36
, pp. 772-782
-
-
Adkinson, K.1
Ojemann, G.A.2
Rapport, R.L.3
Dills, R.L.4
Shen, D.D.5
-
3
-
-
0001395089
-
Valproic acid. Chemistry and biotransformation
-
Levy RH, Mattson RH, and Meldrum BS eds, Raven Press, New York
-
Baillie TA and Sheffels PR (1995) Valproic acid. Chemistry and biotransformation, in Antiepileptic Drugs, 4th edition (Levy RH, Mattson RH, and Meldrum BS eds) pp 589-604, Raven Press, New York.
-
(1995)
Antiepileptic Drugs, 4th Edition
, pp. 589-604
-
-
Baillie, T.A.1
Sheffels, P.R.2
-
4
-
-
0017083764
-
Post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples
-
Caldwell J, Moffatt JR, and Smith RL (1976) Post-mortem survival of hippuric acid formation in rat and human cadaver tissue samples. Xenobiotica 6:275-280.
-
(1976)
Xenobiotica
, vol.6
, pp. 275-280
-
-
Caldwell, J.1
Moffatt, J.R.2
Smith, R.L.3
-
5
-
-
0023864274
-
Valproate-associated hepatotoxicity and its biochemical mechanisms
-
Eadie MJ, Hooper WD, and Dickinson RG (1988) Valproate-associated hepatotoxicity and its biochemical mechanisms. Med Toxicol 3:85-106.
-
(1988)
Med Toxicol
, vol.3
, pp. 85-106
-
-
Eadie, M.J.1
Hooper, W.D.2
Dickinson, R.G.3
-
6
-
-
0038015399
-
-
Ph.D. Thesis, The University of British Columbia, Vancouver, BC, Canada
-
Gopaul SV (1998) The Identification, Characterization, and Profiling of Novel Thiol and Amino Acid Conjugates of Valproic Acid in Humans and Animals. Ph.D. Thesis, The University of British Columbia, Vancouver, BC, Canada.
-
(1998)
The Identification, Characterization, and Profiling of Novel Thiol and Amino Acid Conjugates of Valproic Acid in Humans and Animals
-
-
Gopaul, S.V.1
-
7
-
-
0037677467
-
Amino acid conjugation of valproic acid in humans
-
Gopaul SV, Farrell K, and Abbott FS (1997a) Amino acid conjugation of valproic acid in humans. ISSX Proc 11:205.
-
(1997)
ISSX Proc
, vol.11
, pp. 205
-
-
Gopaul, S.V.1
Farrell, K.2
Abbott, F.S.3
-
8
-
-
4243856852
-
The identification of novel amino acid conjugates of valproic acid in whole brain and cerebral spinal fluid of rat and rabbit using GC/MS and LC/MS/MS
-
Gopaul SV, Tabatabaei AR, and Abbott FS (1997b) The identification of novel amino acid conjugates of valproic acid in whole brain and cerebral spinal fluid of rat and rabbit using GC/MS and LC/MS/MS. Pharma Res (NY) 14:S-355.
-
(1997)
Pharma Res (NY)
, vol.14
-
-
Gopaul, S.V.1
Tabatabaei, A.R.2
Abbott, F.S.3
-
9
-
-
0021711713
-
The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism
-
Granneman GR, Wang SI, Kesterson JW, and Machinist JM (1984a) The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism. Hepatology 4:1153-1158.
-
(1984)
Hepatology
, vol.4
, pp. 1153-1158
-
-
Granneman, G.R.1
Wang, S.I.2
Kesterson, J.W.3
Machinist, J.M.4
-
11
-
-
0011809455
-
Metabolic effects of sequestration of hepatic mitochondrial coenzyme A by valproate and other carboxylic acids
-
Levy RH and Penry JK eds, Raven Press, New York
-
Harris RA, Swartzentruber M, Becker CM, McCune SA, Hu H, and Popov K (1991) Metabolic effects of sequestration of hepatic mitochondrial coenzyme A by valproate and other carboxylic acids, in Idiosyncratic Reactions to Valproate: Clinical Risk Patterns and Mechanisms of Toxicity (Levy RH and Penry JK eds) pp 97-103, Raven Press, New York.
-
(1991)
Idiosyncratic Reactions to Valproate: Clinical Risk Patterns and Mechanisms of Toxicity
, pp. 97-103
-
-
Harris, R.A.1
Swartzentruber, M.2
Becker, C.M.3
McCune, S.A.4
Hu, H.5
Popov, K.6
-
12
-
-
0001913308
-
Amino acid conjugation
-
Mulder GJ ed), Taylor and Francis Ltd., New York
-
Hutt AJ and Caldwell J (1990) Amino acid conjugation, in Conjugation Reactions in Drug Metabolism (Mulder GJ ed) pp 273-305, Taylor and Francis Ltd., New York.
-
(1990)
Conjugation Reactions in Drug Metabolism
, pp. 273-305
-
-
Hutt, A.J.1
Caldwell, J.2
-
13
-
-
0016695591
-
Benzoylglutamic acid, a metabolite of benzoic acid in indian fruit bats
-
Idle JR, Millburn P, and Williams RT (1975) Benzoylglutamic acid, a metabolite of benzoic acid in indian fruit bats. FEBS Lett 59:234-235.
-
(1975)
FEBS Lett
, vol.59
, pp. 234-235
-
-
Idle, J.R.1
Millburn, P.2
Williams, R.T.3
-
14
-
-
0000841697
-
Uber den niederschlag welchen pikrinsäure in normalen harn erzeugt and uber eine neue reakion des kreatinins
-
Jaffe MZ (1886) Uber den Niederschlag welchen pikrinsäure in normalen Harn erzeugt and Uber eine neue Reakion des Kreatinins. Z Physiol Chem 10:391-400.
-
(1886)
Z Physiol Chem
, vol.10
, pp. 391-400
-
-
Jaffe, M.Z.1
-
15
-
-
7144257853
-
Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease
-
Jimenez-Jimenez FJ, Molina JA, Gomez P, Vargas C, de Bustos F, Benito-Leon J, Tallon-Barranco A, Orti-Pareja M, Gasalla T, and Arenas J (1998) Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease. J Neural Transm 105:269-277.
-
(1998)
J Neural Transm
, vol.105
, pp. 269-277
-
-
Jimenez-Jimenez, F.J.1
Molina, J.A.2
Gomez, P.3
Vargas, C.4
De Bustos, F.5
Benito-Leon, J.6
Tallon-Barranco, A.7
Orti-Pareja, M.8
Gasalla, T.9
Arenas, J.10
-
16
-
-
0027528939
-
Amino acids levels in the cerebrospinal fluid of newly diagnosed epileptic patients: Effect of vigabatrin and carbamazepine monotherapies
-
Kälviäinen R, Halonen T, Pitkänen A, and Reikkinen P (1993) Amino acids levels in the cerebrospinal fluid of newly diagnosed epileptic patients: effect of vigabatrin and carbamazepine monotherapies. J Neurochem 60:1244-1250.
-
(1993)
J Neurochem
, vol.60
, pp. 1244-1250
-
-
Kälviäinen, R.1
Halonen, T.2
Pitkänen, A.3
Reikkinen, P.4
-
17
-
-
0032944064
-
Characterization of a renal medium chain acyl-COA synthetase responsible for glycine conjugation in mouse mitochondria
-
Kasuya F, Igarashi K, and Fukui M (1999) Characterization of a renal medium chain acyl-COA synthetase responsible for glycine conjugation in mouse mitochondria. Chem Biol Interact 118:233-246.
-
(1999)
Chem Biol Interact
, vol.118
, pp. 233-246
-
-
Kasuya, F.1
Igarashi, K.2
Fukui, M.3
-
18
-
-
0023934905
-
Penetration of valproate and its active metabolites into cerebrospinal fluid of children with epilepsy
-
Lösher W, Nau H, and Siemes H (1988) Penetration of valproate and its active metabolites into cerebrospinal fluid of children with epilepsy. Epilepsia 29:311-316.
-
(1988)
Epilepsia
, vol.29
, pp. 311-316
-
-
Lösher, W.1
Nau, H.2
Siemes, H.3
-
19
-
-
0030657045
-
Developmental profile of mitochondrial glycine N-acyltransferase in human liver
-
Mawal Y, Paradis K, and Quereshi JA (1997) Developmental profile of mitochondrial glycine N-acyltransferase in human liver. J Pediatr 130:1003-1007.
-
(1997)
J Pediatr
, vol.130
, pp. 1003-1007
-
-
Mawal, Y.1
Paradis, K.2
Quereshi, J.A.3
-
20
-
-
0036153976
-
Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1, 1′-biphenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metaboites by liquid chromatography/mass spectrometry and NMR
-
Mutlib AE, Shockcor J, Chen SY, Espina RJ, Pinto DJ, Orwat MJ, Prakash SR, and Gan LS (2002) Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1, 1′-biphenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metaboites by liquid chromatography/mass spectrometry and NMR. Chem Res Toxicol 15:48-62.
-
(2002)
Chem Res Toxicol
, vol.15
, pp. 48-62
-
-
Mutlib, A.E.1
Shockcor, J.2
Chen, S.Y.3
Espina, R.J.4
Pinto, D.J.5
Orwat, M.J.6
Prakash, S.R.7
Gan, L.S.8
-
21
-
-
0033914344
-
Disposition of glutathione conjugates in rats by a novel glutamic pathway. Characterization of unique peptide conjugates by LC/MS and LC/NMR
-
Mutlib AE, Shockcor J, Espina R, Graciana N, Du A, and Gan LS (2000) Disposition of glutathione conjugates in rats by a novel glutamic pathway. Characterization of unique peptide conjugates by LC/MS and LC/NMR. J Pharmacol Exp Ther 294:735-745.
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 735-745
-
-
Mutlib, A.E.1
Shockcor, J.2
Espina, R.3
Graciana, N.4
Du, A.5
Gan, L.S.6
-
22
-
-
0019495729
-
Amino acid abnormalities in epileptogenic foci
-
Perry TL and Hansen S (1981) Amino acid abnormalities in epileptogenic foci. Neurology 31:872-876.
-
(1981)
Neurology
, vol.31
, pp. 872-876
-
-
Perry, T.L.1
Hansen, S.2
-
23
-
-
0023008117
-
Accumulation and washout kinetics of valproic acid and its active metabolites
-
Pollack GM, McHugh WB, Gengo FM, Ermer JC, and Shen DD (1986) Accumulation and washout kinetics of valproic acid and its active metabolites. J Clin Pharmacol 26:668-676.
-
(1986)
J Clin Pharmacol
, vol.26
, pp. 668-676
-
-
Pollack, G.M.1
McHugh, W.B.2
Gengo, F.M.3
Ermer, J.C.4
Shen, D.D.5
-
24
-
-
0008463095
-
Toxicity
-
Löscher W ed, Birkhauser Verlag, Basel/Switzerland
-
Radatz M and Nau H (1999) Toxicity, in Valproate (Löscher W ed) pp 91-128, Birkhauser Verlag, Basel/Switzerland.
-
(1999)
Valproate
, pp. 91-128
-
-
Radatz, M.1
Nau, H.2
-
25
-
-
0034711537
-
Probenicid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: A microdialysis study
-
Scism JL, Powers KM, Artru AA, Lewis L, and Shen DD (2000) Probenicid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study. Brain Res 884:77-86.
-
(2000)
Brain Res
, vol.884
, pp. 77-86
-
-
Scism, J.L.1
Powers, K.M.2
Artru, A.A.3
Lewis, L.4
Shen, D.D.5
-
26
-
-
0028360139
-
Taurine conjugation of Ibuprofen in humans and rat in liver in vitro
-
Shirley NA, Guan X, Kaiser GW, Halstead GW, and Baillie TA (1994) Taurine conjugation of Ibuprofen in humans and rat in liver in vitro. J Pharmacol Exp Ther 269:1166-1175.
-
(1994)
J Pharmacol Exp Ther
, vol.269
, pp. 1166-1175
-
-
Shirley, N.A.1
Guan, X.2
Kaiser, G.W.3
Halstead, G.W.4
Baillie, T.A.5
-
27
-
-
0038353502
-
Detoxications of aromatics acids with glutamic acid and arginine in spiders
-
Smith JN (1962) Detoxications of aromatics acids with glutamic acid and arginine in spiders. Nature (Lond) 195:399-400.
-
(1962)
Nature (Lond)
, vol.195
, pp. 399-400
-
-
Smith, J.N.1
-
28
-
-
0030886841
-
Time course of α-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal γ-aminobutyric acid levels in comparison to valproic acid
-
Tang W, Palaty J, and Abbott FS (1997) Time course of α-fluorinated valproic acid in mouse brain and serum and its effect on synaptosomal γ-aminobutyric acid levels in comparison to valproic acid. J Pharmacol Exp Ther 282:1163-1172.
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1163-1172
-
-
Tang, W.1
Palaty, J.2
Abbott, F.S.3
-
29
-
-
0027765518
-
Conjugation of benzoic acid with glycine in human liver and kidney: A study on the interindividual variability
-
Temellini A, Mogavero S, Giulianotti PC, Pietrabissa A, Mosca F, and Pacifici GM (1993) Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability. Xenobiotica 23:1427-1433.
-
(1993)
Xenobiotica
, vol.23
, pp. 1427-1433
-
-
Temellini, A.1
Mogavero, S.2
Giulianotti, P.C.3
Pietrabissa, A.4
Mosca, F.5
Pacifici, G.M.6
-
30
-
-
0014700482
-
Properties and reactions of salicyl-coenzyme A
-
Tishler SL and Goldman P (1970) Properties and reactions of salicyl-coenzyme A Biochem Pharmacol 19:143-150.
-
(1970)
Biochem Pharmacol
, vol.19
, pp. 143-150
-
-
Tishler, S.L.1
Goldman, P.2
-
31
-
-
0020512410
-
The effects of valproate intermediary metabolism in isolated rat hepatocytes and intact rats
-
Turnbull DM, Bone AJ, Barlett K, Koundakjian PP, and Sherratt HS (1983) The effects of valproate intermediary metabolism in isolated rat hepatocytes and intact rats. Biochem Pharmacol 32:1887-1892.
-
(1983)
Biochem Pharmacol
, vol.32
, pp. 1887-1892
-
-
Turnbull, D.M.1
Bone, A.J.2
Barlett, K.3
Koundakjian, P.P.4
Sherratt, H.S.5
-
32
-
-
0019469772
-
Human brain, plasma and cerbrospinal fluid concentration of sodium valproate after 72 hours of therapy
-
Vajda FJE, Donnan GA, Phillips J, and Bladin PF (1981) Human brain, plasma and cerbrospinal fluid concentration of sodium valproate after 72 hours of therapy. Neurology 31:486-587.
-
(1981)
Neurology
, vol.31
, pp. 486-587
-
-
Vajda, F.J.E.1
Donnan, G.A.2
Phillips, J.3
Bladin, P.F.4
-
33
-
-
0017066187
-
Identification of separate acyl-CoA:glycine and acyl-CoA: 1-Glutamine N-acyltransferase activities in mitochondrial fractions of rhesus monkey and man
-
Webster LT, Siddiqui UA, Lucas SV, Strong JM, and Mieyal JJ (1976) Identification of separate acyl-CoA:glycine and acyl-CoA:1-glutamine N-acyltransferase activities in mitochondrial fractions of rhesus monkey and man. J Biol Chem 251:3352-3358.
-
(1976)
J Biol Chem
, vol.251
, pp. 3352-3358
-
-
Webster, L.T.1
Siddiqui, U.A.2
Lucas, S.V.3
Strong, J.M.4
Mieyal, J.J.5
-
34
-
-
84908820072
-
Drug metabolism
-
(Foye WO ed) 3rd edition, Lea & Febiger, London
-
Williams DA (1989) Drug metabolism, in Principles of Medicinal Chemistry (Foye WO ed) 3rd edition, pp 100-102, Lea & Febiger, London.
-
(1989)
Principles of Medicinal Chemistry
, pp. 100-102
-
-
Williams, D.A.1
|