Cell culture-adaptive mutations in the NS5B gene of hepatitis C virus with delayed replication and reduced cytotoxicity

Virus Research

Volumn 144, Issue 1-2, 2009, Pages 107-116

  Kang, Ju Il ^a   Kim, Jungsuh P ^a   Wakita, Takaji ^b   Ahn, Byung Yoon ^a  

^a Korea University   (South Korea)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Cell culture adaptive mutation; Cytotoxicity; HCV JFH1; NS5B

Indexed keywords

NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5B;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; DNA CLEAVAGE; GENETIC ANALYSIS; GENOTYPE; GROWTH INHIBITION; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE ANALYSIS; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS REPLICATION;

ADAPTATION, BIOLOGICAL; AMINO ACID SEQUENCE; CELL LINE; CELL SURVIVAL; GENE ORDER; HEPACIVIRUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 69349092195     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2009.04.002     Document Type: Article

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