Reduced expression and desensitization of adenosine A1 receptor/adenylyl cyclase pathway after chronic (-)N6-phenylisopropyladenosine intake during pregnancy

Neuroscience

Volumn 163, Issue 2, 2009, Pages 524-532

  Leon D A ^a   Castillo, C A ^a   Albasanz, J L ^a   Martin M ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

A1R; chronic exposure; pregnancy; regulation

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENYLATE CYCLASE; PHENYLISOPROPYLADENOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; FEMALE; FETUS; GENE EXPRESSION REGULATION; INTERNALIZATION; LONG TERM EXPOSURE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ADENOSINE; ADENYLATE CYCLASE; ANIMALS; BRAIN; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM AGENTS; FEMALE; FORSKOLIN; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; PHENYLISOPROPYLADENOSINE; PREGNANCY; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 69249230913     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.06.050     Document Type: Article

References (54)

1. Adén U., Leverin A.L., Hagberg H., and Fredholm B.B. Adenosine A(1) receptor agonism in the immature rat brain and heart. Eur J Pharmacol 426 (2001) 185-192
2. Albasanz J.L., León D., Ruíz M.A., Fernández M., and Martín M. Adenosine A1 receptor agonist treatment upregulates rat brain metabotropic glutamate receptors. Biochim Biophys Acta 1593 (2002) 69-75
3. Burgueño J., Blake D.J., Benson M.A., Tinsley C.L., Esapa C.T., Canela E.I., Penela P., Mallol J., Mayor Jr. F., Lluis C., Franco R., and Ciruela F. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. J Biol Chem 278 (2003) 37545-37552
4. Chakhtoura N., Angioli R., and Yasin S. Use of adenosine for pharmacological cardioversion of SVT in pregnancy. Prim Care Update Ob Gyns 5 (1998) 154
5. Ciruela F., Casadó V., Rodrigues R.J., Luján R., Burgueño J., Canals M., Borycz J., Rebola N., Goldberg S.R., Mallol J., Cortés A., Canela E.I., López-Giménez J.F., Milligan G., Lluis C., Cunha R.A., Ferre S., and Franco R. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J Neurosci 26 (2006) 2080-2087
6. Cunha R.A. Neuroprotection by adenosine in the brain: from A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal 2 (2005) 111-134
7. Dalpiaz A., and Manfredini S. Adenosine A(1) receptor: analysis of the potential therapeutic effects obtained by its activation in the central nervous system. Curr Med Chem 9 (2002) 1923-1937
8. Dhalla A.K., Shryock J.C., Shreeniwas R., and Belardinelli L. Pharmacology and therapeutic applications of A1 adenosine receptor ligands. Curr Top Med Chem 3 (2003) 369-385
9. Elkayam U., and Goodwin T.M. Adenosine therapy for supraventricular tachycardia during pregnancy. Am J Cardiol 75 (1995) 521-523
10. Escriche M., Burgueno J., Ciruela F., Canela E.I., Mallol J., Enrich C., Lluis C., and Franco R. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling. Exp Cell Res 285 (2003) 72-90
11. Fastbom J., Pazos A., and Palacios J.M. The distribution of adenosine A1 receptors and 5′-nucleotidase in the brain of some commonly used experimental animals. Neuroscience 22 (1987) 813-826
12. Fernandez M., Svenningsson P., and Fredholm B.B. Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine. Life Sci 58 (1996) 769-776
13. Fredholm B.B., Cunha R.A., and Svenningsson P. Pharmacology of adenosine A2A receptors and therapeutic applications. Curr Top Med Chem 3 (2003) 413-426
14. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.N., and Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53 (2001) 527-552
15. Ghatpande S.K., Billington Jr. C.J., Rivkees S.A., and Wendler C.C. Hypoxia induces cardiac malformations via A1 adenosine receptor activation in chicken embryos. Birth Defects Res A Clin Mol Teratol 82 (2008) 121-130
16. Gines S., Ciruela F., Burgueno J., Casado V., Canela E.I., Mallol J., Lluis C., and Franco R. Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line. Mol Pharmacol 59 (2001) 1314-1323
17. Gonzalez-Calero G., Martin M., Cubero A., and Andres A. Bovine brain coated vesicles contain adenosine A1 receptors. Presence of adenylate cyclase coupled to the receptor. J Neurochem 55 (1990) 106-113
18. Green A., Milligan G., and Dobias S.B. Gi down-regulation as a mechanism for heterologous desensitization in adipocytes. J Biol Chem 267 (1992) 3223-3229
19. Halle J.N., Kasper C.E., Gidday J.M., and Koos B.J. Enhancing adenosine A1 receptor binding reduces hypoxic-ischemic brain injury in newborn rats. Brain Res 759 (1997) 309-312
20. Hanoune J., Pouille Y., Tzavara E., Shen T., Lipskaya L., Miyamoto N., Suzuki Y., and Defer N. Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Mol Cell Endocrinol 128 (1997) 179-194
21. Headrick J.P., Gauthier N.S., Berr S.S., Morrison R.R., and Matherne G.P. Transgenic A1 adenosine receptor overexpression markedly improves myocardial energy state during ischemia-reperfusion. J Mol Cell Cardiol 30 (1998) 1059-1064
22. Hettinger B.D., Leid M., and Murray T.F. Cyclopentyladenosine-induced homologous down-regulation of A1 adenosine receptors (A1AR) in intact neurons is accompanied by receptor sequestration but not a reduction in A1AR mRNA expression or G protein alpha-subunit content. J Neurochem 71 (1998) 221-230
23. Hettinger-Smith B.D., Leid M., and Murray T.F. Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells. J Neurochem 67 (1996) 1921-1930
24. Higuchi R., Fockler C., Dollinger G., and Watson R. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology 11 (1993) 1026-1030
25. Hosl P., Rust M., Johannigmann J., and Schmidt G. Paroxysmal supraventricular tachycardia in pregnancy. Value of adenosine and other anti-arrhythmia agents. Geburtshilfe Frauenheilkd 56 (1996) 313-316
26. Hunter C.J., Bennet L., Power G.G., Roelfsema V., Blood A.B., Quaedackers J.S., George S., Guan J., and Gunn A.J. Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep. Stroke 34 (2003) 2240-2245
27. Hutchinson S.A., and Scammells P.J. A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential. Curr Pharm Des 10 (2004) 2021-2039
28. Jacobson K.A., and Gao Z.G. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5 (2006) 247-264
29. Johansson B., Halldner L., Dunwiddie T.V., Masino S.A., Poelchen W., Gimenez-Llort L., Escorihuela R.M., Fernandez-Teruel A., Wiesenfeld-Hallin Z., Xu X.J., Hardemark A., Betsholtz C., Herlenius E., and Fredholm B.B. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A 98 (2001) 9407-9412
30. Klaasse E.C., Ijzerman A.P., de Grip W.J., and Beukers M.W. Internalization and desensitization of adenosine receptors. Purinergic Signal 4 (2008) 21-37
31. Lee H.T., Cuomo-Scholer A., Belloni F.L., and Thompson C.I. Regulation of renal A(1) adenosine receptors in vivo. Exp Nephrol 10 (2002) 43-50
32. Leffler S., and Johnson D.R. Adenosine use in pregnancy: lack of effect on fetal heart rate. Am J Emerg Med 10 (1992) 548-549
33. León D.A., Albasanz J.L., Castillo C.A., Iglesias I., and Martín M. Effect of chronic gestational treatment with the adenosine A1 receptor agonist R-phenylisopropyladenosine on metabotropic glutamate receptors/phospholipase C pathway in maternal and fetal brain. J Neurosci Res 86 (2008) 3295-3305
34. 1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. J Neurochem 82 (2002) 625-634
35. León D., Albasanz J.L., Ruiz M.A., and Martin M. Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain. Neuroscience 131 (2005) 481-489
36. Longabaugh J.P., Didsbury J., Spiegel A., and Stiles G.L. Modification of the rat adipocyte A1 adenosine receptor-adenylate cyclase system during chronic exposure to an A1 adenosine receptor agonist: alterations in the quantity of GS alpha and Gi alpha are not associated with changes in their mRNAs. Mol Pharmacol 36 (1989) 681-688
37. Matherne G.P., Linden J., Byford A.M., Gauthier N.S., and Headrick J.P. Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia. Proc Natl Acad Sci U S A 94 (1997) 6541-6546
38. Mons N., Harry A., Dubourg P., Premont R.T., Iyengar R., and Cooper D.M. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proc Natl Acad Sci U S A 92 (1995) 8473-8477
39. Nie Z., Mei Y., and Ramkumar V. Short term desensitization of the A1 adenosine receptors in DDT1MF-2 cells. Mol Pharmacol 52 (1997) 456-464
40. Olsson R.A., and Pearson J.D. Cardiovascular purinoceptors. Physiol Rev 70 (1990) 761-845
41. Prystowsky E.N., Niazi I., Curtis A.B., Wilber D.J., Bahnson T., Ellenbogen K., Dhala A., Bloomfield D.M., Gold M., Kadish A., Fogel R.I., Gonzalez M.D., Belardinelli L., Shreeniwas R., and Wolff A.A. Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist. J Am Coll Cardiol 42 (2003) 1098-1102
42. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50 (1998) 413-492
43. Ramkumar V., Hallam D.M., and Nie Z. Adenosine, oxidative stress and cytoprotection. Jpn J Pharmacol 86 (2001) 265-274
44. Ramkumar V., Kwatra M., Benovic J.L., Stiles G.L., and Stilesa G.L. Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase. Biochim Biophys Acta 1179 (1993) 89-97
45. Ramkumar V., Olah M.E., Jacobson K.A., and Stiles G.L. Distinct pathways of desensitization of A1- and A2-adenosine receptors in DDT1 MF-2 cells. Mol Pharmacol 40 (1991) 639-647
46. Rivkees S.A., Zhao Z., Porter G., and Turner C. Influences of adenosine on the fetus and newborn. Mol Genet Metab 74 (2001) 160-171
47. Roman V., Keijser J.N., Luiten P.G., and Meerlo P. Repetitive stimulation of adenosine A1 receptors in vivo: changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia. Brain Res 1191 (2008) 69-74
48. Ruiz A., Sanz J.M., Gonzalez-Calero G., Fernandez M., Andres A., Cubero A., and Ros M. Desensitization and internalization of adenosine A1 receptors in rat brain by in vivo treatment with R-PIA: involvement of coated vesicles. Biochim Biophys Acta 1310 (1996) 168-174
49. Sarrió S., Casadó V., Escriche M., Ciruela F., Mallol J., Canela E.I., Lluis C., and Franco R. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Mol Cell Biol 20 (2000) 5164-5174
50. Turner C.P., Yan H., Schwartz M., Othman T., and Rivkees S.A. A1 adenosine receptor activation induces ventriculomegaly and white matter loss. Neuroreport 13 (2002) 1199-1204
51. Vendite D., Sanz J.M., Lopez-Alanon D.M., Vacas J., Andres A., and Ros M. Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells. Neurochem Res 23 (1998) 211-218
52. Wendler C.C., Amatya S., McClaskey C., Ghatpande S., Fredholm B.B., and Rivkees S.A. A1 adenosine receptors play an essential role in protecting the embryo against hypoxia. Proc Natl Acad Sci U S A 104 (2007) 9697-9702
53. Yan L., Burbiel J.C., Maass A., and Muller C.E. Adenosine receptor agonists: from basic medicinal chemistry to clinical development. Expert Opin Emerg Drugs 8 (2003) 537-576
54. Zhang L. Prenatal hypoxia and cardiac programming. J Soc Gynecol Invest 12 (2005) 2-13