Enhancing adenosine A1 receptor binding reduces hypoxic-ischemic brain injury in newborn rats

Brain Research

Volumn 759, Issue 2, 1997, Pages 309-312

  Halle, Judith N ^a   Kasper, Christine E ^b   Gidday, Jeffrey M ^c   Koos, Brian J ^a  

^a Dept Obstet Gynecol Brain Res I ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

Binding enhancer; Brain damage; Neonatal; Neuroprotection; PD 81,273; Perinatal asphyxia

Indexed keywords

2 AMINO 3 BENZOYLTHIOPHENE DERIVATIVE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; PD 81273; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR; THIOPHENE DERIVATIVE;

ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN LEVEL; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; ANIMAL; ANOXIA; BRAIN INJURY; DRUG POTENTIATION; METABOLISM; NON-PROGRAMMATIC; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

NON-PROGRAMMATIC;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; BRAIN INJURIES; BRAIN ISCHEMIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; THIOPHENES;

EID: 0030610582     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00364-8     Document Type: Article

References (28)

1. Andine P., Thordstein M., Kjeller I., Nordborg C., Thiringer K., Wennberg E., Hagberg H. Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia. J. Neurosci. 35:1990;253-260.
2. Barks J., Post M., Tuor U. Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat. Pediatr. Res. 29:1991;558-563.
3. Bhattacharya S., Linden J. The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochim. Biophys. Acta. 1265:1995;15-21.
4. 1 adenosine receptors. Mol. Pharmacol. 50:1996;104-111.
5. Bruns R.F., Fergus J.H. Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Mol. Pharmacol. 38:1990;939-949.
6. Bruns R.F., Fergus J.H., Coughenour L.L., Courtland G.G., Pugsley T.A., Dodd J.H., Tinney F.J. Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes. Mol. Pharmacol. 38:1990;950-958.
7. 1 receptor enhancer, PD 81,273, and cerebral ischemia/reperfusion injury in the gerbil. Gen. Pharmacol. 26:1995;1545-1548.
8. Dobbing J., Sands J. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3:1979;79.
9. Geiger J.D., LaBella F.S., Nagy J.I. Ontogenesis of adenosine receptors in the central nervous system of the rat. Brain Res. 315:1984;97-104.
10. Gidday J., Fitzgibbons J., Shah A., Kraujalis M., Park T.S. Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine. Pediatr. Res. 38:1995;306-311.
11. Goldberg M., Monyer H., Weiss J., Choi D. Adenosine reduces cortical neuronal injury induced by oxygen or glucose deprivation in vitro. Neurosci. Lett. 89:1988;323-327.
12. Hagberg H., Anderson P., Lacarewiticz J., Jaacobson I., Butcher S., Sandberg M. Extracellular adenosine, inosine, hypoxanthine and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemic damage in the neonatal rat. J. Neurochem. 49:1987;227-231.
13. Irshad F., Dagenais G., Fedor E., Cavanaugh J. Trials with an adenosine analog as antianginal medication. Clin. Pharmacol. Ther. 22:1977;470-474.
14. Janusz C.A., Berman R.F. The adenosine binding enhancer, PD 81,273 inhibits epileptiform bursting in the hippocampal brain slice. Brain Res. 619:1993;131-136.
15. Janusz C.A., Bruns R.F., Berman R.F. Functional activity of the adenosine binding enhancer, PD 81,273 in the in vitro hippocampal slice. Brain Res. 567:1991;181-187.
16. Koos B.J., Mason B.A., Punla O., Adinolfi A. Hypoxic inhibition of breathing in fetal sheep: Relation to brain adenosine concentrations. J. Appl. Physiol. 77:1994;2734-2739.
17. Marangos P.J., Patel J., Stivers J. Ontogeny of adenosine binding sites in rat forebrain and cerebellum. J. Neurochem. 39:1982;267-270.
18. Mizumura T., Auchampach J.A., Linden J., Bruns R.F., Gross G.J. PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ. Res. 79:1996;415-423.
19. Morgan P.F., Montgomery P., Marangos P.J. Ontogenetic profile of the adenosine uptake sites in rat forebrain. J. Neurochem. 49:1987;852-855.
20. Mudumbi R.V., Montamat S.C., Bruns R.F., Vestal R.E. Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor. Am. J. Physiol. 264:1993;H1017-H1022.
21. J.W. Phillis, Adenosine, inosine, and the oxypurines in cerebral ischemia, in: A. Schurr and B. Rigor (Eds.), Cerebral Ischemia and Resuscitation, CRC Press, Boca Raton, FL, 1990, pp. 189-204.
22. Rice J., Vannucci R.C., Brierley J. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9:1981;131-141.
23. Silverstein F.S., Torke L., Barks J., Johnston M.V. Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain. Brain Res. 431:1987;33-39.
24. Smith D.O. Sources of adenosine released during neuromuscular transmission in the rat. J. Physiol. (Lond). 432:1991;343-354.
25. Sylven C., Beerman B., Johnzon B., Brandt R. Angina pectoris-like pain provoked by intravenous adenosine in healthy volunteers. Br. Med. J. 293:1986;227-230.
26. van Wylen D., Park T., Rubio R., Berne R. Increases in cerebral interstitial fluid adenosine concentration during hypoxia, local potassium infusion and ischemia. J. Cereb. Blood Flow Metab. 6:1986;522-528.
27. D. Von Lubitz, J. Dambrosia, O. Kempski and D. Redmond, Cyclohexyladenosine protects against neuronal death following ischemia in the CA1 region of gerbil hippocampus, Stroke, 19 (1988) 1133-1139.
28. L.B. Wingard, T.M. Brody, J. Larner and A. Schwartz, Human Pharmacology: Molecular to Clinical, Mosby Year Book, St. Louis, 1991, p. 17.