Repetitive stimulation of adenosine A1 receptors in vivo: Changes in receptor numbers, G-proteins and A1 receptor agonist-induced hypothermia

Brain Research

Volumn 1191, Issue , 2008, Pages 69-74

  Roman, Viktor ^a   Keijser, Jan N ^a   Luiten, Paul G M ^a   Meerlo, Peter ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Adenosine; Cyclopentyladenosine; Neurodegeneration; Neuroprotection; Receptor desensitization

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; N 6 CYCLOPENTYLADENOSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; HIPPOCAMPUS; HYPOTHERMIA; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SOMATOSENSORY CORTEX;

ADENOSINE; ANALYSIS OF VARIANCE; ANIMALS; BODY TEMPERATURE REGULATION; DOWN-REGULATION; GTP-BINDING PROTEINS; HIPPOCAMPUS; HYPOTHERMIA; MALE; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1; SIGNAL TRANSDUCTION; SOMATOSENSORY CORTEX; STATISTICS, NONPARAMETRIC;

RATTUS; RATTUS NORVEGICUS;

EID: 38349035731     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.11.044     Document Type: Article

References (35)

1. Abbracchio M.P., Fogliatto G., Paoletti A.M., Rovati G.E., and Cattabeni F. Prolonged in vitro exposure of rat brain slices to adenosine analogues: selective desensitization of adenosine A1 but not A2 receptors. Eur. J. Pharmacol. 227 (1992) 317-324
2. Alanko L.O., Laitinen J.T., Stenberg D., and Porkka-Heiskanen T. Adenosine A1 receptor-dependent G-protein activity in the rat brain during prolonged wakefulness. NeuroReport 15 (2004) 2133-2137
3. Anderson R., Sheehan M.J., and Strong P. Characterization of the adenosine receptors mediating hypothermia in the conscious mouse. Br. J. Pharmacol. 113 (1994) 1386-1390
4. Basheer R., Strecker R.E., Thakkar M.M., and McCarley R.W. Adenosine and sleep-wake regulation. Prog. Neurobiol. 73 (2004) 379-396
5. Benington J.H., Kodali S.K., and Heller H.C. Stimulation of A1 adenosine receptors mimic the electroencephalographic effects of sleep deprivation. Brain Res. 692 (1995) 79-85
6. Bohm S.K., Grady E.F., and Bunnett N.W. Regulatory mechanisms that modulate signaling by G-protein-coupled receptors. Biochem. J. 322 (1997) 1-18
7. Ciruela F., Saura C., Canela E.I., Mallol J., Lluis C., and Franco R. Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors. Mol. Pharmacol. 52 (1997) 788-797
8. De Mendonca A., Sebastiao A.M., and Ribeiro J.A. Adenosine: does it have a neuroprotective role after all?. Brain Res. Rev. 33 (2000) 258-274
9. Dunwiddie T.V., and Worth T. Sedative and anticonvulsant effects of adenosine analogs in mouse and rat. J. Pharmacol. Exp. Ther. 220 (1982) 70-76
10. Dunwiddie T.V., and Masino S.A. The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci. 24 (2001) 31-55
11. Ferguson S.S.G., and Caron M.G. G protein-coupled receptor adaptation mechanisms. Semin. Cell Dev. Biol. 9 (1998) 119-127
12. Fredholm B.B., Ijzerman A.P., Jacobson K.A., Klotz K.N., and Linden J. International Union of Pharmacology: XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53 (2001) 527-552
13. Georgiev V., Johansson B., and Fredholm B.B. Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number. Brain Res. 612 (1993) 271-277
14. 35S]-GTPγS binding as measured by quantitative autoradiography following chronic agonist administration. Br. J. Pharmacol. 132 (2001) 605-611
15. Hettinger-Smith B.D., Leid M., and Murray T.F. Chronic exposure to adenosine receptor agonists and antagonists reciprocally regulates the A1 adenosine receptor-adenylyl cyclase system in cerebellar granule cells. J. Neurochem. 67 (1996) 1921-1930
16. Jacobson K.A. Specific ligands for the adenosine receptor family. Neurotransmissions 12 (1996) 1-7
17. Jacobson K.A., Von Lubitz D.K.J.E., Daly J.W., and Fredholm B.B. Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol. Sci. 17 (1996) 108-113
18. Klinger M., Freissmuth M., and Nanoff C. Adenosine receptors: G protein-mediated signaling and the role of accessory proteins. Cell. Signal. 14 (2002) 99-108
19. 35S]guanosine-5′-(γ-thio) triphosphate autoradiography. Neuroscience 90 (1999) 1265-1279
20. Malhotra J., and Gupta Y.K. Effect of adenosine receptor modulation on pentylenetetrazole-induced seizures in rats. Br. J. Pharmacol. 120 (1997) 282-288
21. Meerlo P., Roman V., Farkas E., Keijser J.N., Nyakas C., and Luiten P.G.M. Ageing-related decline in adenosine A1 receptor binding in the rat brain: an autoradiographic study. J. Neurosci. Res. 78 (2004) 742-748
22. 35S]GTPγS binding assays. Trends Pharmacol. Sci. 24 (2003) 87-90
23. 35S]GTPγS binding in brain modulation by endogenous adenosine. Neuropharmacology 39 (2000) 282-289
24. Paxinos G., and Watson G. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, Sydney
25. Porkka-Heiskanen T., Alanko L., Kalinchuk A., and Stenberg D. Adenosine and sleep. Sleep Med. Rev. 6 (2002) 321-332
26. Ribeiro J.A., Sebastiao A.M., and de Mendoca A. Adenosine receptors in the central nervous system: pathophysiological implications. Prog. Neurobiol. 68 (2002) 377-392
27. Rudolphi K.A., Schubert P., Parkinson F.E., and Fredholm B.B. Neuroprotective role of adenosine in cerebral ischemia. Trends Pharmacol. Sci. 13 (1992) 439-445
28. Ruiz M.A., Sanz J.M., Gonzalez-Calgero G., Fernandez M., Andres A., Cubero A., and Ros M. Desensitization and internalization of adenosine A1 receptors in rat brain by in vivo treatment with R-PIA: involvement of coated vesicles. Biochem. Biophys. Acta 1310 (1996) 168-174
29. Ruiz M.A., Albasanz J.L., Leon D., Ros M., Andres A., and Martin M. Different modulation of inhibitory and stimulatory pathways mediated by adenosine after chronic in vivo agonist exposure. Brain Res. 1031 (2005) 211-221
30. 35S]thio]-triphosphate binding. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 7242-7246
31. 1A receptor-activated G-proteins in the rat brain. Brain Res. Bull. 44 (1997) 39-45
32. 3H]Cyclohexyladenosine binding in the rat brain: a pharmacological analysis using quantitative autoradiography. Neurosci. Lett. 68 (1986) 41-46
33. Ticho S.R., and Radulovacki M. Role of adenosine in sleep and temperature regulation in the preoptic area of rats. Pharmacol. Biochem. Behav. 40 (1991) 33-40
34. Von Lubitz D.K., Lin R.C., Melman N., Ji X.-D., Carter M.F., and Jacobson K.A. Chronic administration of selective adenosine A1 receptor agonist and antagonist in cerebral ischemia. Eur. J. Pharmacol. 256 (1994) 161-167
35. Yaar R., Jones M.R., Chen J.F., and Ravid K. Animal models for the study of adenosine receptor function. J. Cell. Physiol. 202 (2005) 9-20