Desensitization of adenosine A1 receptor-mediated inhibition of adenylyl cyclase in cerebellar granule cells

Neurochemical Research

Volumn 23, Issue 2, 1998, Pages 211-218

  Vendite, Deusa ^b   Sanz, Juana María ^a   López Alañon, Dulce M ^a   Vacas, Javier ^a   Andrés, Antonio ^a   Ros, Manuel ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Adenosine A1 receptor; Adenylyl cyclase; Cerebellum; Desensitization; G protein; Granule cells

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE DEAMINASE; ADENYLATE CYCLASE; CYCLIC AMP; CYCLOHEXYLADENOSINE; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; PHENYLISOPROPYLADENOSINE; TRITIUM; ADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; N (1 METHYL 2 PHENYLETHYL)ADENOSINE; N-(1-METHYL-2-PHENYLETHYL)ADENOSINE;

ANIMAL CELL; ARTICLE; BRAIN MICROSOME; CELL MEMBRANE; CEREBELLUM; CONTROLLED STUDY; ENZYME INHIBITION; GRANULE CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALIA; TRITIUM;

ADENOSINE; ADENYLATE CYCLASE; ANIMALS; CELLS, CULTURED; CEREBELLUM; GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0031594469     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022437110269     Document Type: Article

References (36)

1. Hausdorff, W. P., Caron, M. G., and Lefkowitz, R. J. 1990. Turning off the signal desensitization of β-adrenergic receptor function. FASEB J. 4:2881-2889.
2. Willians, M. 1987. Purine receptors in mammalian tissues: pharmacology and functional significance. Annu. Rev. Pharmacol. Toxicol. 27:315-345.
3. Olah, M. E., Ren, H., and Stiles, G. L. 1995. Adenosine receptors: protein and gene structure. Archives internationales de Pharmacodynamie et de therapie. 329:135-150.
4. 1 adenosine receptor agonist. J. Biol. Chem. 262:15702-15707.
5. 1 sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. J. Biol. Chem. 265:2506-5210.
6. 1 adenosine receptor-Adenylate cyclase system in rat adipocytes. J. Biol. Chem. 262:841-847.
7. 1 adenosine agonist: alterations in the quantity of αGs and αGi are not associated with changes in their mRNAs. Mol. Pharmacol. 36:681-688.
8. 1-adenosine receptor in embryonic chicken heart. Am. J. Physiol. 256 (Heart Circ. Physiol. 25), H321-H327.
9. 1 adenosine receptor-mediated inhibition of cardiac myocyte contractility and adenylate cyclase activity. Circ. Res. 67: 406-411.
10. Lee, H. T., Thompson, C. T., Hernández, A., Lewy, J. L., and Belloni, F. L. 1993. Cardiac desensitization to adenosine analogues after prolonged R-PIA infusion in vivo. Am J. Physiol. 265. (Heart Circ. Physiol. 34) H1916-H1927.
11. 1 MF-2 cells. Mol. Pharmacol. 40:639-647.
12. 1 receptors in rat brain by in vivo treatment with R-PIA: involvement of coated vesicles. Biochim. Biophysis. Acta 1310:168-174.
13. 1 adenosine-receptor phosphorylation by β-adrenergic receptor kinase. Biochim. Biophys. Acta. 1179:89-97.
14. Palmer, T. M., Benovic, J. L., and Stiles, G. L. 1966. Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. J. Biol. Chem. 271:15272-15278.
15. Fernández, M., Svenningsson, P., and Fredholm, B. B. 1996. Adaptative changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine. Life Sci. 58:769-776.
16. 2 receptors. Eur. J. Pharmacol. 227:317-324.
17. Thangnipon, W., Kingsbury, A., Webb, M., and Balázs, R. 1983. Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes. Dev. Brain Res. 11:177-189.
18. 1 receptors in cultured cerebellar granule cells. Role of endogenous adenosine. J. Neurochem. 67:1469-1477.
19. 1 adenosine receptor-adenylyl cyclase system in cerebellar granulle cells. J. Neurochem. 67:1921-1930.
20. Brown, B. L., Albano, J. D. H., Ekins, R., Sgherzi, A. M., and Tampion, W. 1971. A simple method for the measurement of adenosine 3;5-cyclic monophosphate. Biochem. J. 121:561-562.
21. Ros, M., Northup, J. K., and Malbon, C. C. 1988. Steady-state levels of G-proteins and β-adrenergic receptors in rat fat cells. J. Biol. Chem. 263:4362-4368.
22. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
23. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
24. Waldo, G. L., Northrup, J. K., Perkins, J. P., and Harden, T. K. 1983. Characterization of an altered membrane form of the β-adrenergic receptor produced during agonist-induced desensitization. J. Biol. Chem. 258:13900-13908.
25. Sibley, D. R., and Lefkowitz, R. J. 1985. Molecular mechanism of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model. Nature 317:124-129.
26. Milligan, G., and Green, A. 1991. Agonist control G-proteins levels. Trends Pharmacol. Sci. 12:207-209.
27. Hadcock, J. R., and Malbon, C. C. 1988. Down-regulation of β-adrenergic receptor: agonist-induced reduction in receptor mRNA levels. Proc. Natl. Acad. Sci. USA 85:5015-5021.
28. Hadcock J. R., and Malbon, C. C. 1993. Agonist regulation of gene expression of adrenergic receptors and G-proteins. J. Neurochem. 60:1-9.
29. 2 adenosine receptor binding and on mRNA levels in rat brain. Naunyn-Schmedeber's Arch. Pharmacol. 347:407-414.
30. 2-adrenergic receptor gene in response to short-term agonist exposure. Proc. Natl. Acad. Sci. USA. 86:4853-4857.
31. 1 receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins. Brain Res. 507:195-199.
32. Ciruela, R., Saura, C., Canela, E. T., Mallol, J., Lluis, C., and Franco, R. 1996. Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors. FEBS Lett. 380:219-223.
33. Hadcock, J. R., Port, J. D., and Malbon, C. C. 1991. Cross-regulation between G-protein-mediated pathways. J. Biol. Chem. 266: 11915-11922.
34. 11 and of muscarinic ml acetylcholine receptors from plasma membranes to a light-vesicular membrane fraction. Eur. J. Biochem. 224:455-462.
35. Ott, S., Costa, T., and Herz, A. 1989. Opiod receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins. J. Neurochem. 52:619-626.
36. Haraguchi, K., and Rodbell, M. 1987. Isoproterenol stimulates shift of G proteins from plasma membrane to pinocytotic vesicles in rat adipocytes: a possible means of signal dissemination. Proc. Natl. Acad. Sci. USA. 87:1208-1212.