Do sauna therapy and exercise act by raising the availability of tetrahydrobiopterin?

Medical Hypotheses

Volumn 73, Issue 4, 2009, Pages 610-613

  Pall, Martin L ^a  

^a The Tenth Paradigm Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEAT SHOCK PROTEIN 90; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; TETRAHYDROBIOPTERIN;

ARTICLE; CHRONIC FATIGUE SYNDROME; CHRONIC INFLAMMATION; DETOXIFICATION; ENDOTHELIAL DYSFUNCTION; EXERCISE; FIBROMYALGIA; HEART FAILURE; HUMAN; HYPERTENSION; HYPERTHERMIC THERAPY; MUSCLE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; SAUNA; SHEAR STRESS; VASCULAR ENDOTHELIUM;

BIOLOGICAL AVAILABILITY; BIOPTERIN; COMBINED MODALITY THERAPY; EXERCISE THERAPY; FATIGUE SYNDROME, CHRONIC; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, BIOLOGICAL; STEAM BATH;

MAMMALIA;

EID: 69249222525     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.03.058     Document Type: Article

References (82)

1. Gibson P.R., Elms A.N.-M., and Ruding L.A. Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity. Environ Health Perspect 111 (2003) 1498-1504
2. Rea W.J. Chemical sensitivity (1992), Lewis Publishers, Boca Raton, FL
3. Crinnion W. Components of practical clinical detox programs - sauna as a therapeutic tool. Altern Ther Health Med 13 (2007) S154-S156
4. Baird D.N., and Rea W.J. The temperomandibular joint implant controversy. Part II: its clinical implications. J Nutr Environ Med 9 (1999) 209-222
5. Rogers S.A. Detoxify or die (2002), Prestige Publishers, Syracuse, New York
6. Krop J. Chemical sensitivity after intoxication at work with solvents: response to sauna therapy. J Altern Complement Med 4 (1998) 77-86
7. Masuda A., Munemoto T., and Tei C. A new treatment: thermal therapy for chronic fatigue syndrome. Nippon Rinsho 65 (2007) 1093-1098
8. Brockow T., Wagner A., Franke A., Offenbacher M., and Resch K.L. A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthemia as an adjunct to standard multimodal rehabilitation in the treatment of fibromyalgia. Clin J Pain 23 (2007) 67-75
9. Matsushita K., Masuda A., and Tei C. Efficacy of Waon therapy for fibromyalgia. Intern Med 47 (2008) 1473-1476
10. Masuda A., Kihara T., Fukudome T., Shinsato T., Minagoe S., and Tei C. Successful thermal therapy for end-stage peripheral artery disease. J Cardiol 47 (2006) 163-164
11. Biro S., Masuda A., Kihara T., and Tei C. Clinical implications of thermal therapy in lifestyle-related diseases. Exp Biol Med (Maywood) 228 (2003) 1245-1249
12. Ozkor M.A., and Quyyumi A.A. Tetrahydrobiopterin. Curr Hypertens Rep 10 (2008) 58-64
13. Kihara T., Biro S., Imamura M., et al. Repeated sauna treatment improves vascular endothelial and cardiac function in patients with chronic heart failure. J Am Col Cardiol 39 (2002) 754-759
14. Nguyen Y., Naseer N., and Frishman W.H. Sauna therapeutic option for cardiovascular disease. Cardiol Rev 12 (2004) 321-324
15. Kisanuki A., Daitoku S., Kihara T., Otsuji Y., and Tei C. Thermal therapy improves left ventricular diastolic function in patients with congestive heart failure: a tissue doppler echocardiographic study. J Cardiol 49 (2007) 187-191
16. Porkert M., Sher S., Reddy U., et al. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens 22 (2008) 401-407
17. Antoniades C., Shirodaria C., Crabtree M., et al. Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial dysfunction and inflammation. Circulation 116 (2007) 2851-2859
18. Yamamoto E., Kataoka K., Shintaku H., et al. Novel mechanism and role of angiotensin II induced vascular endothelial dysfunction injury in hypertensive diastolic heart failure. Arterioscler Thromb Vasc Biol 27 (2007) 2569-2575
19. Cosentino F., Hurlimann D., Delli Gatti C., et al. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 94 (2008) 487-492
20. Moens A.L., and Kass D.A. Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. J Cardiovasc Pharmacol 50 (2007) 238-246
21. Schmidt T.S., and Alp N.J. Mechanisms for the role of tetrahydrobiopterin in endothelial dysfunction and vascular disease. Clin Sci (London) 113 (2007) 47-63
22. Setoguchi S., Hirooka Y., Eshima K., Shimokawa H., and Takeshita A. Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure. J Cardiovasc Pharmacol 39 (2002) 363-368
23. Pall M.L. Explaining "unexplained illnesses": disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia, post-traumatic stress disorder, gulf war syndrome and others (2007), Harrington Park (Haworth) Press, Bighamton, NY
24. Pall ML. Multiple chemical sensitivity: toxicological questions and mechanisms. In: Ballantyne Bryan, Marrs Timothy C, Syversen Tore, editors. General and applied toxicology. 3rd ed. New York: Wiley and Sons; in press.
25. Pall M.L. The NO/ONOO-cycle as the cause of fibromyalgia and related illnesses: etiology, explanation and effective therapy. In: Pederson J.A. (Ed). New research in fibromyalgia (2006), Nova Biomedical Publishers, New York 39-59
26. Pall ML. The NO/ONOO-vicious cycle mechanism as the cause of chronic fatigue syndrome/myalgic encephalomyelitis. In: New research in chronic fatigue syndrome. New York: Nova Biomedical Publishers.
27. Pall M.L. Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO-cycle. Med Hypotheses 69 (2007) 821-825
28. Moore K.P., Darley-Usmar V., Morrow J., and Roberts II L.J. Formation of F2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite. Circ Res 77 (1995) 335-341
29. Romero J.C., and Reckelhoff J.F. State-of-the-art lecture. Role of angiotensin and oxidative stress in essential hypertension. Hypertension 34 (1999) 943-949
30. Zou M.H. Peroxynitrite and protein tyrosine nitration of prostacyclin synthase. Prostaglandins Other Lipid Mediat 82 (2007) 119-127
31. Ferroni P., Basili S., Paoletti V., and Davì G. Endothelial dysfunction and oxidative stress in arterial hypertension. Nutr Metab Cardiovasc Dis 16 (2006) 222-233
32. Myatt L., and Webster R.P. Vascular biology in preeclampsia. J Thromb Haemost (2008) [Epub ahead of print]
33. Vuori I. Sauna bather's circulation. Ann Clin Res 20 (1988) 249-256
34. Drettner B. The effect of sauna bath on the peripheral blood flow. Acta Soc Med Ups 69 (1964) 279-290
35. Smolander J., and Louhevaara V. Effect of heat stress on muscle blood flow during dynamic handgrip exercise. Endocrinol Exp 19 (1985) 277-281
36. Widmer R.J., Laurinec J.E., Young M.F., Laine G.A., and Quick C.M. Local heat produces a shear-mediated biphasic response in the thermoregulatory microcirculation in the Pallid bat wing. Am J Physiol Regul Integr Comp Physiol 291 (2006) R625-R632
37. De Bono J.P., and Channon K.M. Endothelial cell tetrahydrobiopterin: going with the flow. Circ Res 101 (2007) 752-754
38. Lam C.-.F., Peterson T.E., Richardson D.M., et al. Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol 290 (2006) H786-H793
39. Widder J.D., Chen W., Li L., et al. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res 101 (2007) 830-838
40. Mun G.I., An S.M., Park H., Jo H., and Boo Y.C. Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells. Am J Physiol Heart Circ 295 (2008) H1966-H1973
41. McClung J.P., Hasday J.D., He J.R., et al. Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells. Am J Physiol Regul Integr Comp Physiol 294 (2008) 185-191
42. Lepock J.R. How do cells respond to their thermal environment?. Int J Hyperthermia 21 (2005) 681-687
43. Basu S., and Srivastava P.K. Fever-lie temperature induces maturation of dendritic cells through induction of Hsp90. Int Immunol 15 (2003) 1053-1061
44. Huang H., Lee W.C., Lin J.H., et al. Molecular cloning and characterization of porcine cDNA encoding a 90-kDa heat shock protein and its expression following hyperthermia. Gene 226 (1999) 307-315
45. Cvoro A., Dunjdjerski J., Trajkovic D., and Matic G. Association of rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon whole body hyperthermic stress. J Steroid Biochem Mol Biol 67 (1998) 319-325
46. Swick L., and Kapatos G. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. J Neurochem 97 (2006) 1447-1455
47. Hwu W.L., Lu M.Y., Hwa K.Y., Fan S.W., and Lee Y.M. Molecular chaperones affect GTP cyclohydrolase I mutations in dopa-responsive dystonia. Ann Neurol 55 (2004) 875-878
48. Whitsett J., Picklo Sr. M.J., and Vasquez-Vivar J. 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. Arterioscler Thromb Vasc Biol 27 (2007) 2340-2347
49. Pritchard Jr. K.A., Ackerman A.W., Gross E.R., et al. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric oxide synthase. J Biol Chem 276 (2001) 17621-17624
50. Ou J., Ou Z., Ackerman A.W., Oldham K.T., and Pritchard Jr. K.A. Inhibition of heat shock protein 90 (Hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. Free Radic Biol Med 34 (2003) 269-276
51. Zhang X., Jin Y., Xia L., Tao X., Bai M., and Zhang J. Hsp90 mediates the balance of nitric oxide and superoxide anion in the lungs of rats with acute pulmonary thromboembolism. Int Immunopharmacol 9 (2009) 43-48
52. Whitsett J., Martásek P., Zhao H., et al. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic Biol Med 40 (2006) 2056-2068
53. Mizutani M., Hashimoto R., Ohta T., Nazakawa K., and Nagatsu T. The effect of exercise on plasma biopterin levels. Neuropsychobiology 29 (1994) 53-65
54. Eskurza I., Myerburgh L.A., Kahn Z.D., and Seals D.R. Tetrahydrobiopterin augments endothelium-dependent dilation in sedentary but not in habitually exercising older adults. J Physiol 568 Pt 3 (2005) 1057-1065
55. Grijalva J., Hicks S., Zhao X., et al. Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizawa (GK) rats. Cardiovasc Diabetol 7 (2008) 34
56. Widder J.D., Chen W., Li L., Dikalov S., Thöny B., Hatakeyama K., et al. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res 101 (2007) 830-838
57. Feilchenfeld Z., Yücel Y.H., and Gupta N. Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma. Exp Eye Res 87 (2008) 409-414
58. Mozaffarieh M., and Flammer J. A novel perspective on natural therapeutic approaches in glaucoma therapy. Expert Opin Emerg Drugs 12 (2007) 195-198
59. Umehara M., Yamaguchi A., Itakura S., et al. Repeated Waon therapy improves pulmonary hypertension during exercise in patients with severe chronic obstructive pulmonary disease. J Cardiol 51 (2008) 106-113
60. Ichinose M., Sugiura H., Yamagata S., Koarai A., and Shirato K. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am J Respir Crit Care Med 162 (2000) 701-706
61. Ricciardolo F.L., Di Stefano A., Sabatini F., and Folkerts G. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol 533 (2006) 240-252
62. Foxton R.H., Land J.M., and Heales S.J. Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms. Neurochem Res 32 (2007) 751-756
63. Casal J.A., Robles A., and Tutor J.C. Serum markers of monocyte/macrophage activation in patients with Alzheimer's disease and other types of dementia. Clin Biochem 36 (2003) 553-556
64. Torreilles F., Salman-Tabcheh S., Guérin M., and Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res Brain Res Rev 30 (1999) 153-163
65. Aziz A.A., Leeming R.J., and Blair J.A. Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type. J Neurol Neurosurg Psychiatry 46 (1983) 410-413
66. Heales S., Crawley F., and Rudge P. Reversible Parkinsonism following heroin pyrolysate inhalation is associated with tetrahydrobiopterin deficiency. Mov Disord 19 (2004) 1248-1251
67. Nagatsu T., and Sawada M. Biochemistry of postmortem brains in Parkinson's disease: a historical overview and future prospects. J Neural Transm Suppl 72 (2007) 113-120
68. Toda Y., Mori K., Hashimoto T., et al. Administration of secretin for autism alters dopamine metabolism in the central nervous system. Brain Dev 28 (2006) 99-103
69. Danfors T., von Knorring A.L., Hartvig P., et al. Tetrahydrobiopterin in the treatment of children with autistic disorder: a double-blind placebo-controlled crossover study. J Clin Psychopharmacol 25 (2005) 485-489
70. Fernell E., Watanabe Y., Adolfsson I., et al. Possible effects of tetrahydrobiopterin treatment in six children with autism-clinical and positron emission tomography data: a pilot study. Dev Med Child Neurol 39 (1997) 313-318
71. Komori H., Matsuishi T., Yamada S., Yamashita Y., Ohtaki E., and Kato H. Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism. J Autism Dev Disord 25 (1995) 183-193
72. Tani Y., Fernell E., Watanabe Y., Kanai T., and Långström B. Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients. Neurosci Lett 181 (1994) 169-172
73. Yoshida S., Lee Y.H., Hassan M., et al. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis in alveolar macrophages. Respiration 68 (2001) 299-306
74. Gilchrist M., Hesslinger C., and Befus A.D. Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells. J Biol Chem 278 (2003) 50607-50614
75. Pritchard Jr. K.A., Shi Y., and Konduri G.G. Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice. Circulation 111 (2005) 2022-2024
76. Khoo J.P., Zhao L., Alp N.J., Bendall J.K., Nicoli T., Rockett K., et al. Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension. Circulation 111 (2005) 212621-212633
77. Richardson M.A., Read L.L., Taylor Clelland C.L., et al. Evidence for a tetrahydrobiopterin deficit in schizophrenia. Neuropsychobiology 52 4 (2005) 190-201
78. Richardson M.A., Read L.L., Reilly M.A., Clelland J.D., and Clelland C.L. Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder. Neurochem Res 32 (2007) 107-113
79. Settergren M., Böhm F., Malmström R.E., Channon K.M., and Pernow J. l-Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis 44 (2008) 66 [Epub ahead of print]
80. Chew G.T., and Watts G.F. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the "recoupling hypothesis". QJM 97 (2004) 537-548
81. Heitzer T., Krohn K., Albers S., and Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 43 (2000) 1435-1438
82. Nyström T., Nygren A., and Sjöholm A. Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. Am J Physiol Endocrinol Metab 287 5 (2004) E919-E925