Endothelial cell tetrahydrobiopterin: Going with the flow

Circulation Research

Volumn 101, Issue 8, 2007, Pages 752-754

  De Bono, Joseph P ^a   Channon, Keith M ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Blood flow; Nitric oxide; Shear stress

Indexed keywords

CASEIN KINASE II; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HYDROGEN PEROXIDE; INSULIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; SMALL INTERFERING RNA; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; BIOPTERIN; DRUG DERIVATIVE; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; BIOSYNTHESIS; BLOOD FLOW; EDITORIAL; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EUKARYOTIC CELL; GCH1 GENE; GENE; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; VASCULAR DISEASE; ANIMAL; BLOOD FLOW VELOCITY; METABOLISM; NOTE; PHYSIOLOGY;

ANIMALS; BIOPTERIN; BLOOD FLOW VELOCITY; ENDOTHELIAL CELLS; HUMANS; REGIONAL BLOOD FLOW;

EID: 35448967464     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.162503     Document Type: Editorial

References (23)

1. Chatzizisis YS, Coskun AU, Jonas M, et al. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379-2393.
2. Davis ME, Cai H, Drummond GR, Harrison DG. Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ Res. 2001;89:1073-1080.
3. Ozaki M, Kawashima S, Yamashita T, c17 Hirase T, Namiki M, Inoue N, Hirata K, Yasui H, Sakurai H, Yoshida Y, Masada M, Yokoyama M. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest. 2002; 110:331-340.
4. Bendall JK, Alp NJ, Warrick N. Stoichiometric relationships between endothelial tetrahydrobiopterin, eNOS activity and eNOS coupling in vivo: Insights from transgenic mice with endothelial-targeted GTPCH and eNOS over-expression. Circ Res. 2005;97:864-871.
5. Vasquez-Vivar J, Kalyanaraman B, Martasek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic Res. 2003;37:121-127.
6. Laursen JB, Somers M, Kurz S. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation. 2001;103:1282-1288.
7. Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTPcyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol. 2004;24:445-450.
8. Hattori Y, Hattori S, Wang X. Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol. 2007;865-70.
9. Widder JD, Chen W, Li L, c17 Dikalov S, Thony B, Hatakeyama K, Harrison DG. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res. 2007;101:830-838.
10. Thony B, Auerbach G, Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J. 2000;347 Pt 1:1-16.
11. Milstien S, Jaffe H, Kowlessur D, Bonner TI. Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J Biol Chem. 1996;271:19743-19751.
12. Hatakeyama K, Inoue Y, Harada T, Kagamiyama H. Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway. J Biol Chem. 1991;266:765-769.
13. Imazumi K, Sasaki T, Takahashi K, Takai Y. Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells. Biochem Biophys Res Commun. 1994;205:1409-1416.
14. Hesslinger C, Kremmer E, Hultner L, Ueffing M, Ziegler I. Phosphorylation of GTP cyclohydrolase I and modulation of Its activity in rodent mast cells. GTP cyclohrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protien kinase C. J Biol Chem. 1998;273:21616-21622.
15. Lapize C, Pluss C, Werner ER, Huwiler A, Pfeilschifter J. Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells. Biochem Biophys Res Commun. 1998;251:802-805.
16. Olsten ME, Weber JE, Litchfield DW. CK2 interacting proteins: emerging paradigms for CK2 regulation? Mol Cell Biochem. 2005;274: 115-124.
17. Meggio F, Pinna LA. One-thousand-and-one substrates of protein kinase CK2? FASEB J. 2003;17:349-368.
18. Park HS, Lee SM, Lee JH. Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity. Biochem J. 2001; 358:783-790.
19. Fleming I. Signaling by the angiotensin-converting enzyme. Circ Res. 2006;98:887-896.
20. Dunzendorfer S, Lee HK, Tobias PS. Flow-dependent regulation of endothelial Toll-like receptor 2 expression through inhibition of SP1 activity. Circ Res. 2004;95:684-691.
21. Landmesser U, Dikalov S, Price SR, c17 McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest. 2003;111:1201-1209.
22. Alp NJ, Mussa S, Khoo J, c17 Cai S, Guzik T, Jefferson A, Goh N, Rockett KA, Channon KM. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest. 2003;112:725-735.
23. Lam CF, Peterson TE, Richardson DM. Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol. 2006;290:H786-H793.