Tetrahydrobiopterin in the treatment of children with autistic disorder: A double-blind placebo-controlled crossover study

Journal of Clinical Psychopharmacology

Volumn 25, Issue 5, 2005, Pages 485-489

  Danfors, Torsten ^a,c   Von Knorring, Anne Liis ^a   Hartvig, Per ^b   Langstrom, Bengt ^c,d   Moulder, Robert ^c   Stromberg, Bo ^a   Torstenson, Richard ^c   Wester, Ulrika ^a   Watanabe, Yasuyoshi ^e   Eeg Olofsson, Orvar ^a  

^a Department of Neuroscience ^*  (Sweden)

^b Hospital Pharmacy   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d Uppsala Imanet AB   (Sweden)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TETRAHYDROBIOPTERIN;

AGITATION; ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DROWSINESS; FATIGUE; FEMALE; HEADACHE; HUMAN; INTELLIGENCE QUOTIENT; INTERPERSONAL COMMUNICATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RATING SCALE; SCORING SYSTEM; SIDE EFFECT; SLEEP DISORDER; SOCIAL INTERACTION; STEREOTYPY; STOMACH PAIN; VOMITING;

AUTISTIC DISORDER; BIOPTERIN; CHILD; CHILD, PRESCHOOL; COMMUNICATION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTELLIGENCE TESTS; INTERPERSONAL RELATIONS; MALE; PSYCHIATRIC STATUS RATING SCALES; STEREOTYPED BEHAVIOR; TREATMENT OUTCOME;

EID: 25444519551     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jcp.0000177667.35016.e9     Document Type: Article

References (16)

1. Koshimura K, Miwa S, Lee K, et al. Enhancement of dopamine release in vivo from the rat striatum by dialytic perfusion of 6R-L-erythro-5,6,7,8- tetrahydrobiopterin. J Neurochem. April 1990;54(4):1391-1397.
2. Mataga N, Imamura K, Watanabe Y. L-threo-3,4-Dihydroxyphenylserine enhanced ocular dominance plasticity in adult cats. Neurosci Lett. August 17, 1992;142(2):115-118.
3. Tani Y, Fernell E, Watanabe Y, et al. Decrease in 6R-5,6,7,8- tetrahydrobiopterin content in cerebrospinal fluid of autistic patients. Neurosci Lett. 1994;181(1-2):169-172.
4. Komori H, Matsuishi T, Yamada S, et al. Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism. J Autism Dev Disord. 1995;25(2):183-193.
5. Shintaku H. Disorders of tetrahydrobiopterin metabolism and their treatment. Curr Drug Metab. 2002;3(2):123-131.
6. Naruse H, Hayashi T, Takesada M, et al. Therapeutic effect of tetrahydrobiopterin in infantile autism. Proc Jpn Acad. 1987;63B:231-233.
7. Nagahata M, Kazamatsuri H, Naruse H, et al. Clinical evaluation of apropterin hydrochloride (R-THBP, SUN 0588) on infantile autism-a multicenter cooperative study. Rinshou Iyaku. 1990;(6):1877-1899.
8. Takesada M, Naruse H, Nagahata M, et al. An open clinical study of aprpterin hydrochloride (R-tetrahydrobiopterin, R-THBP) in infantile autism - clinical effects and long-term follow-up. Paper presented at the International Symposium on Neurobiology of Infantile Autism; 1990; November 10-11, Tokyo, Japan.
9. Fernell E, Watanabe Y, Adolfsson I, et al. Possible effects of tetrahydrobiopterin treatment in six children with autism-clinical and positron emission tomography data; a pilot study. Dev Med Child Neurol. 1997;39(5):313-318.
10. Schopler E, Reichler RJ, DeVellis RF, et al. Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). J Autism Dev Disord. 1980;10(1):91-103.
11. Alin-Åkerman B., Nordberg L. Griffiths Developmental Scales I and II. Stockholm: Psykologifbrlaget AB; 1980.
12. Naruse H, Hayashi T, Takesada M. A preliminary study on clinical effect of tetrahydrobiopterin in infantile autism: new drug development. Ministry of Health and Welfare, Stockholm, Sweden; 1985;71-81.
13. Hollander E, Phillips AT, Yeh CC. Targeted treatments for symptom domains in child and adolescent autism. Lancet. August 30, 2003;362(9385):732-734.
14. Aman MG, Novotny S, Samango-Sprouse C, et al. Outcome measures for clinical drug trials in autism. CNS Spectr. January 2004;9(1):36-47.
15. Volkmar FR. Pharmacological interventions in autism: theoretical and practical issues. J Clin Child Psychol. 2001;30(1):80-87.
16. Roseman B, Schneider E, Crimmins D, et al. What to measure in autism drug trials. J Autism Dev Disord. 2001;31(3):361-362.