4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 11, 2007, Pages 2340-2347

  Whitsett, Jennifer ^a   Picklo Sr , Matthew J ^c   Vasquez Vivar, Jeannette ^b,d  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b FREE RADICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF NORTH DAKOTA   (United States)

^d NONE   (United States)

Author keywords

2 hydroxyethidium; Ascorbate; eNOS phosphorylation; Glutathione; Tetrahydrobiopterin

Indexed keywords

4 HYDROXYNONENAL; ASCORBIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ETHIDIUM; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SEPIAPTERIN; SERINE; SUPEROXIDE; TETRAHYDROBIOPTERIN; 4-HYDROXY-2-NONENAL; 5,6,7,8-TETRAHYDROBIOPTERIN; ALDEHYDE; BIOPTERIN; DRUG DERIVATIVE; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; CONTROLLED STUDY; ELECTROCHEMISTRY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; INHIBITION KINETICS; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; VASCULAR ENDOTHELIUM; ANIMAL; CATTLE; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHYSIOLOGY;

ALDEHYDES; ANIMALS; AORTA; BIOPTERIN; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; GTP CYCLOHYDROLASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEASOME ENDOPEPTIDASE COMPLEX; SUPEROXIDES;

EID: 36048937528     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.107.153742     Document Type: Article

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