Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: Association with treatment response

Journal of Clinical Immunology

Volumn 29, Issue 5, 2009, Pages 620-628

  Haas, Stephan L ^a   Wei, Christel ^a   Bugert, Peter ^a   Gundt, Jutta ^a   Witt, Heiko ^b   Singer, Manfred V ^a   Berg, Thomas ^b   Böcker, Ulrich ^a  

^a MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Antiviral therapy; Genetic alterations; Hepatitis C; Interleukin 18; Treatment outcome

Indexed keywords

ALPHA2A INTERFERON; ALPHA2B INTERFERON; INTERLEUKIN 18; PEGINTERFERON; RIBAVIRIN;

ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; DRUG TREATMENT FAILURE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOTYPE; HEPATITIS C; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RELAPSE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-18; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROGNOSIS; PROMOTER REGIONS, GENETIC; RIBAVIRIN; RNA, VIRAL; TREATMENT OUTCOME;

EID: 69249220140     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-009-9302-z     Document Type: Article

References (42)

1. Global surveillance and control of hepatitis C. Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat. 1999;6:35-47. doi: 10.1046/j.1365-2893. 1999.6120139.x (Pubitemid 29077623)
2. GM Lauer BD Walker 2001 Hepatitis C virus infection N Engl J Med. 345 41 52 10.1056/NEJM200107053450107 (Pubitemid 32634271)
3. JJ Feld TJ Liang 2006 Hepatitis C-identifying patients with progressive liver injury Hepatology. 43 S194 206 10.1002/hep. 21065
4. J Massard V Ratziu D Thabut, et al. 2006 Natural history and predictors of disease severity in chronic hepatitis C J Hepatol. 44 S19 24 10.1016/j.jhep. 2005.11.009
5. JJ Feld JH Hoofnagle 2005 Mechanism of action of interferon and ribavirin in treatment of hepatitis C Nature. 436 967 972 10.1038/nature04082 (Pubitemid 41191673)
6. N Paladino H Fainboim G Theiler, et al. 2006 Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism J Virol. 80 9144 9150 10.1128/JVI.00339-06 (Pubitemid 44359986)
7. N Dharel N Kato R Muroyama, et al. 2006 MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C Clin Cancer Res. 12 4867 4871 10.1158/1078-0432.CCR-06-0111 (Pubitemid 44338572)
8. M Sartori S Andorno M Pagliarulo, et al. 2007 Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C Gut. 56 693 698 10.1136/gut.2006.106641 (Pubitemid 46662937)
9. P Strnad TC Lienau GZ Tao, et al. 2006 Keratin variants associate with progression of fibrosis during chronic hepatitis C infection Hepatology. 43 1354 1363 10.1002/hep.21211 (Pubitemid 43980115)
10. N Kato G Ji Y Wang, et al. 2005 Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C Hepatol. 42 846 853 10.1002/hep.20860 (Pubitemid 41401122)
11. JA Gracie SE Robertson IB McInnes 2003 Interleukin-18 J Leukoc Biol. 73 213 224 10.1189/jlb.0602313 (Pubitemid 36158296)
12. K Nakanishi T Yoshimoto H Tsutsui H Okamura 2001 Interleukin-18 regulates both Th1 and Th2 responses Annu Rev Immunol. 19 423 474 10.1146/annurev. immunol.19.1.423 (Pubitemid 32368042)
13. P Reddy 2004 Interleukin-18: recent advances Curr Opin Hematol. 11 405 410 10.1097/01.moh.0000141926.95319.42 (Pubitemid 39491434)
14. H Okamura H Tsutsi T Komatsu, et al. 1995 Cloning of a new cytokine that induces IFN-gamma production by T cells Nature. 378 88 91 10.1038/378088a0
15. H Tsutsui K Matsui H Okamura K Nakanishi 2000 Pathophysiological roles of interleukin-18 in inflammatory liver diseases Immunol Rev. 174 192 209 10.1034/j.1600-0528.2002.017418.x
16. R Faggioni J Jones-Carson DA Reed, et al. 2000 Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18 Proc Natl Acad Sci U S A 97 2367 2372 10.1073/pnas.040561297 (Pubitemid 30134075)
17. R Faggioni RC Cattley J Guo, et al. 2001 IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice J Immunol. 167 5913 5920
18. J Vecchiet K Falasca P Cacciatore, et al. 2005 Association between plasma interleukin-18 levels and liver injury in chronic hepatitis C virus infection and non-alcoholic fatty liver disease Ann Clin Lab Sci. 35 415 422
19. HY Jia J Du SH Zhu, et al. 2002 The roles of serum IL-18, IL-10, TNF-alpha and sIL-2R in patients with chronic hepatitis C Hepatobiliary Pancreat Dis Int. 1 378 382
20. V Giedraitis B He WX Huang J Hillert 2001 Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation J Neuroimmunol. 112 146 152 10.1016/S0165-5728(00) 00407-0
21. N Hirankarn C Manonom P Tangkijvanich Y Poovorawan 2007 Association of interleukin-18 gene polymorphism (-607A/A genotype) with susceptibility to chronic hepatitis B virus infection Tissue Antigens. 70 160 163 10.1111/j.1399-0039.2007.00865.x (Pubitemid 47024832)
22. M Imboden L Nicod A Nieters, et al. 2006 The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study Clin Exp Allergy. 36 211 218 10.1111/j.1365-2222.2006.02424.x
23. L Tiret T Godefroy E Lubos, et al. 2005 Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease Circulation. 112 643 650 10.1161/CIRCULATIONAHA.104. 519702 (Pubitemid 41099042)
24. T Takada E Suzuki K Morohashi F Gejyo 2002 Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis in a Japanese population Tissue Antigens. 60 36 42 10.1034/j.1399-0039.2002.600105.x (Pubitemid 35177022)
25. P Bossu A Ciaramella F Salani, et al. 2008 Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment Brain Behav Immun. 22 487 492 10.1016/j.bbi.2007.10.001
26. P Bossu A Ciaramella ML Moro, et al. 2007 Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease J Neurol Neurosurg Psychiatry. 78 807 811 10.1136/jnnp.2006.103242 (Pubitemid 47204582)
27. Y Hiromatsu T Mukai H Kaku, et al. 2006 IL-18 gene polymorphism confers susceptibility to the development of anti-GAD65 antibody in Graves' disease Diabet Med. 23 211 215 10.1111/j.1464-5491.2005.01734.x
28. T Sugiura N Maeno Y Kawaguchi, et al. 2006 A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population Arthritis Res Ther 8 R60 10.1186/ar1930
29. PJ Scheuer 1991 Classification of chronic viral hepatitis: a need for reassessment J Hepatol. 13 372 374 10.1016/0168-8278(91) 90084-O
30. AR Lloyd E Jagger JJ Post, et al. 2007 Host and viral factors in the immunopathogenesis of primary hepatitis C virus infection Immunol Cell Biol. 85 24 32 10.1038/sj.icb.7100010 (Pubitemid 46067318)
31. TK Oleksyk CL Thio AL Truelove, et al. 2005 Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance Genes Immun. 6 347 357 10.1038/sj.gene.6364188 (Pubitemid 40903408)
32. WG Abbott E Rigopoulou P Haigh, et al. 2004 Single nucleotide polymorphisms in the interferon-gamma and interleukin-10 genes do not influence chronic hepatitis C severity or T-cell reactivity to hepatitis C virus Liver Int. 24 90 97 10.1111/j.1478-3231.2004.00904.x
33. EJ Minton D Smillie P Smith, et al. 2005 Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, -6, or -10 genes Hum Immunol. 66 127 132 10.1016/j.humimm.2004.11.001 (Pubitemid 40208199)
34. BJ Hennig AJ Frodsham S Hellier, et al. 2007 Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection Liver Int. 27 1134 1143 10.1111/j.1478-3231.2007.01518.x (Pubitemid 47399449)
35. S Finotto J Siebler M Hausding, et al. 2004 Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo Gut. 53 392 400 10.1136/gut.2003.018572 (Pubitemid 38241337)
36. K Kimura K Kakimi S Wieland LG Guidotti FV Chisari 2002 Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice J Virol. 76 10702 10707 10.1128/JVI.76.21.10702-10707.2002 (Pubitemid 35176186)
37. N Fujioka R Akazawa K Ohashi M Fujii M Ikeda M Kurimoto 1999 Interleukin-18 protects mice against acute herpes simplex virus type 1 infection J Virol. 73 2401 2409
38. M Tanaka-Kataoka T Kunikata S Takayama, et al. 1999 In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection Cytokine. 11 593 599 10.1006/cyto.1998.0453 (Pubitemid 29368977)
39. L Shapiro AJ Puren HA Barton, et al. 1998 Interleukin 18 stimulates HIV type 1 in monocytic cells Proc Natl Acad Sci USA 95 12550 12555 10.1073/pnas.95.21.12550 (Pubitemid 28483802)
40. PA Zhang JM Wu Y Li XS Yang 2005 Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population World J Gastroenterol. 11 1594 1598 (Pubitemid 40520797)
41. P An CL Thio GD Kirk S Donfield JJ Goedert CA Winkler 2008 Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance J Infect Dis. 198 1159 1165 10.1086/592047
42. N Bouzgarrou E Hassen E Schvoerer, et al. 2008 Association of interleukin-18 polymorphisms and plasma level with the outcome of chronic HCV infection J Med Virol. 80 607 614 10.1002/jmv.21079 (Pubitemid 351358557)