Kinetics and effects of dichloroacetic acid in rainbow trout

Aquatic Toxicology

Volumn 94, Issue 3, 2009, Pages 186-194

  Fitzsimmons, Patrick N ^a   Hoffman, Alex D ^a   Lien, Gregory J ^a   Hammermeister, Dean E ^a   Nichols, John W ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Dichloroacetic acid; Disinfection byproducts; Halogenated acetic acids; Kinetics; Trout

Indexed keywords

CARRIER PROTEIN; DICHLOROACETIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ZETA; LACTIC ACID; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE; UNCLASSIFIED DRUG;

ACETIC ACID; CELL ORGANELLE; CONCENTRATION (COMPOSITION); DIFFUSION; DISINFECTION; METABOLISM; MUSCLE; NUTRIENT UPTAKE; POLLUTION EXPOSURE; PROTEIN; REACTION KINETICS; SALMONID; TOXICITY;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE SECRETION; BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ECOTOXICITY; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; GILL; KIDNEY CLEARANCE; LACTATE BLOOD LEVEL; LIVER LEVEL; LIVER METABOLISM; LUNG CLEARANCE; LUNG FUNCTION; METABOLIC CLEARANCE RATE; NONHUMAN; PRIORITY JOURNAL; RAINBOW TROUT; RESPIROMETRY; SIGNAL TRANSDUCTION; STEADY STATE; TISSUE DISTRIBUTION; TOXICOKINETICS; WATER POLLUTION;

ANIMALS; BIOTRANSFORMATION; DICHLOROACETATE; GILLS; INJECTIONS; METABOLIC CLEARANCE RATE; ONCORHYNCHUS MYKISS; TISSUE DISTRIBUTION; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; MAMMALIA; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 69249218862     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2009.07.001     Document Type: Article

References (51)

1. Anderson W.B., Board P.G., Gargano B., and Anders M.W. Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking α-haloalkanoic acids. Chem. Res. Toxicol. 12 (1999) 1144-1149
2. Barron M.G., Tarr B.D., and Hayton W.L. Temperature-dependence of cardiac output and regional blood flow in rainbow trout, Salmo gairdneri Richardson. J. Fish Biol. 31 (1987) 735-744
3. Bersin R.M., and Stacpoole P.W. Dichloroacetate as metabolic therapy for myocardial ischemia and failure. Am. Heart J. 134 (1997) 841-855
4. Brown J.A., and Gore D.C. In vivo metabolic response of glucose to dichloroacetate in humans. J. Surg. Res. 61 (1996) 391-394
5. Carlson R.W., Lien G.W., and Holmen B.A. An Automated Monitoring System for Fish Physiology and Toxicology. EPA/600/3-89/011 (1989), U.S. Environmental Protection Agency, Duluth, MN
6. Crabb D.W., Yount E.A., and Harris R.A. The metabolic effects of dichloroacetate. Metabolism 30 (1981) 1024-1039
7. Curtis J.B., and Wood C.M. The function of the urinary bladder in vivo in the freshwater rainbow trout. J. Exp. Biol. 155 (1991) 567-583
8. DeAngelo A.B., Daniel F.B., Most B.M., and Olson G.R. The carcinogenicity of dichloroacetic acid in the male fischer 344 rat. Toxicology 114 (1996) 207-221
9. Erickson R.J., McKim J.M., Lien G.J., Hoffman A.D., and Batterman S.L. Uptake and elimination of ionizable organic chemicals at fish gills. I. Model formulation, parameterization, and behavior. Environ. Toxicol. Chem. 25 (2006) 1512-1521
10. Erickson R.J., McKim J.M., Lien G.J., Hoffman A.D., and Batterman S.L. Uptake and elimination of ionizable organic chemicals at fish gills. II. Observed and predicted effects of pH, alkalinity, and chemical properties. Environ. Toxicol. Chem. 25 (2006) 1522-1532
11. Gibaldi M., and Perrier D. Pharmacokinetics. 2nd ed. (1982), Marcel Dekker, New York, NY pp. 409-417
12. Gonzalez-Leon A., Schultz I.R., Xu G., and Bull R.J. Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking water. Toxicol. Appl. Pharmacol. 146 (1997) 189-195
13. Gonzalez-Leon A., Merdink J.L., Bull R.J., and Schultz I.R. Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice. Chem. Biol. Interact. 123 (1999) 239-253
14. Halestrap A.P. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem. J. 148 (1975) 85-96
15. Herren-Freund S.L., Pereira M.A., Khoury M.D., and Olson G. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol. 90 (1987) 183-189
16. Hunter III S.E., Blanton M.R., Rogers E.H., Mole M.L., Andrews J., and Chernoff N. Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro. Reprod. Toxicol. 22 (2006) 443-448
17. James M.O., Cornett R., Yan Z., Henderson G.N., and Stacpoole P.W. Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats. Drug Metab. Dispos. 25 (1997) 1223-1227
18. 14C]dichloroacetate in male Sprague-Dawley rats. Drug Metab. Dispos. 26 (1998) 1134-1143
19. Krasner S.W., McGuire M.J., Jacangelo J.G., Patania N.L., Reagan K.M., and Aieta E.M. The occurrence of disinfection by-products in US drinking water. J. Am. Water Works Assoc. 81 (1989) 41-53
20. Laberee K., and Milligan C.L. Lactate transport across sarcolemmal vesicles isolated from rainbow trout white muscle. J. Exp. Biol. 202 (1999) 2167-2175
21. Larson J.L., and Bull R.J. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115 (1992) 268-277
22. Lin E.L.C., Mattox J.K., and Daniel F.B. Tissue distribution, excretion and urinary metabolites of dichloroacetic acid in the male fischer 344 rat. J. Toxicol. Environ. Health 38 (1993) 19-32
23. McHugh Law J., Lopez L., and DeAngelo A.B. Hepatotoxicity of the drinking water disinfection by-product, dichloroacetic acid, in the medaka small fish model. Toxicol. Lett. 94 (1998) 19-27
24. McKim J.M., and Goeden H.M. A direct measure of the uptake efficiency of a xenobiotic chemical across the gills of brook trout (Salvelinus fontinalis) under normoxic and hypoxic conditions. Comp. Biochem. Physiol. 72C (1982) 65-74
25. McKim J., Schmieder P., and Veith G. Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient. Toxicol. Appl. Pharmacol. 77 (1985) 1-10
26. McKim J.M., Schmieder P.K., Carlson R.W., Hunt E.P., and Niemi G.J. Use of respiratory-cardiovascular responses of rainbow trout (Salmo gairdneri) in identifying acute toxicity syndromes in fish: Part 1. Pentachlorophenol, 2,4-dinitrophenol, tricaine methanesulfonate and 1-octanol. Environ. Toxicol. Chem. 6 (1987) 295-312
27. Milligan C.L. Metabolic recovery from exhaustive exercise in rainbow trout. Comp. Biochem. Physiol. 113A (1996) 51-60
28. Milligan C.L., and Wood C.M. Tissue intracellular acid-base status and the fate of lactate after exhaustive exercise in the rainbow trout. J. Exp. Biol. 123 (1986) 123-144
29. i after exhaustive activity in rainbow trout (Salmo gairdneri) and starry flounder (Platichthys stellatus). J. Exp. Biol. 133 (1987) 263-282
30. Nichols D.J. Fluid volumes in rainbow trout, Salmo gairdneri: application of compartmental analysis. Comp. Biochem. Physiol. 87A (1987) 703-709
31. Nichols J.W., McKim J.M., Lien G.J., Hoffman A.D., and Bertelsen S.L. Physiologically based toxicokinetic modeling of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss). Toxicol. Appl. Pharmacol. 110 (1991) 374-389
32. Nichols J.W., Fitzsimmons P.N., Whiteman F.W., Dawson T.D., Babeu L., and Juenemann J. A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. I. Feeding studies with 2,2′,5,5′-tetrachlorobiphenyl. Toxicol. Sci. 77 (2004) 206-218
33. Pagnotta A., Brooks L., and Milligan L. The potential regulatory roles of cortisol in recovery from exhaustive exercise in rainbow trout. Can. J. Zool. 72 (1994) 2136-2146
34. Richardson S.D., Simmons J.E., and Rice G. Disinfection byproducts: the next generation. Environ. Sci. Technol. 36 (2002) 198A-205A
35. Saarikoski J., Lindstrom R., Tyynelä M., and Viluksela M. Factors affecting the absorption of phenolics and carboxylic acids in the guppy (Poecilia reticulate). Ecotoxicol. Environ. Saf. 11 (1986) 158-173
36. Saghir S.A., and Schultz I.R. Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naïve and GSTζ-depleted rats. Environ. Health Perspect. 110 (2002) 757-763
37. Sanz A., Cardenete G., Hidalgo F., and Garcia-Gallego M. Study of biliary secretion in trout (Oncorhynchus mykiss) by cannulation of bile duct. Comp. Biochem. Physiol. 104A (1993) 525-529
38. Schultz I.R., Merdink J.L., Gonzalez-Leon A., and Bull R.J. Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats. Toxicol. Appl. Pharmacol. 158 (1999) 103-114
39. Schultz I.R., Reed S., Pratt A., and Skillman A.D. Quantitative oral dosing of water soluble and lipophilic contaminants in the Japanese medaka (Oryzias latipes). Comp. Biochem. Physiol. 145C (2007) 86-95
40. Stacpoole P.W. The pharmacology of dichloroacetate. Metabolism 38 (1989) 1124-1144
41. Stacpoole P.W., and Greene Y.J. Dichloroacetate. Diabetes Care 15 (1992) 785-791
42. Stacpoole P.W., Barnes C.L., Hurbanis M.D., Cannon S.L., and Kerr D.S. Treatment of congenital lactic acidosis with dichloroacetate. Arch. Dis. Child. 77 (1997) 535-541
43. Thorson T. The partitioning of body water in osteichthyes: phylogenetic and ecological implications in aquatic vertebrates. Biol. Bull. 120 (1961) 238-254
44. Tong Z., Board P.G., and Anders M.W. Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other α-haloacids. Chem. Res. Toxicol. 11 (1998) 1332-1338
45. Turner J.D., Wood C.M., and Clark D. Lactate and proton dynamics in the rainbow trout (Salmo gairdneri). J. Exp. Biol. 104 (1983) 247-268
46. Uden P.C., and Miller J.W. Chlorinated acids and chloral in drinking water. J. Am. Water Works Assoc. 75 (1983) 524-527
47. Ward K.W., Rogers E.H., and Hunter III S.E. Comparative pathogenesis of haloacetic acid and protein kinase inhibitor embryotoxicity in mouse whole embryo culture. Toxicol. Sci. 53 (2000) 118-126
48. Williams D.T., LeBel G.L., and Benoit F.M. Disinfection by-products in Canadian drinking water. Chemosphere 34 2 (1997) 299-316
49. Weber J.M. Effect of endurance swimming on the lactate kinetics of rainbow trout. J. Exp. Biol. 158 (1991) 463-476
50. Wolf K. Physiological salines for fresh-water teleosts. Prog. Fish Cult. 25 (1963) 135-140
51. Xu G., Stevens D.K., and Bull R.J. Metabolism of bromodichloroacetate in B6C3F1 mice. Drug Metab. Dispos. 23 (1995) 1412-1416