Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-ζ-depleted rats

Environmental Health Perspectives

Volumn 110, Issue 8, 2002, Pages 757-763

  Saghir, Shakil A ^a,c   Schultz, Irvin R ^a,b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

Animal study; Dichloroacetic acid; Drinking water disinfection by products; Halogenated acetic acids; Human in vitro metabolism; Human risk assessment; Low dose pharmacokinetics; Oral bioavailability; Rat in vitro metabolism; Toxicology

Indexed keywords

DICHLOROACETIC ACID; DRINKING WATER; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; CANNULATION; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME KINETICS; FEEDING; FEMALE; FLUID INTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; JUGULAR VEIN; LIVER CYTOSOL; LIVER METABOLISM; MALE; METABOLIC CLEARANCE RATE; METABOLISM; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAT; URINARY EXCRETION; WATER CONTAMINATION;

ANIMALIA;

EID: 0036054892     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110757     Document Type: Article

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