Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats: Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate

Drug Metabolism and Disposition

Volumn 26, Issue 11, 1998, Pages 1134-1143

  James, Margaret O ^a   Yan, Zimeng ^b   Cornett, Rachel ^b   Jayanti, V Murali K M ^b   Henderson, George N ^b   Davydova, Natalia ^b   Katovich, Michael J ^b   Pollock, Brad ^b   Stacpoole, Peter W ^b  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; CARBON 14; CARBON DIOXIDE; DICHLOROACETIC ACID; DRUG METABOLITE; GLYCINE DERIVATIVE; GLYOXYLIC ACID; HIPPURIC ACID; OXALIC ACID; PHENYLACETYLGLYCINE; UNCLASSIFIED DRUG; CARBON; GLYCINE; HIPPURIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; EXPIRED AIR; FEEDING; LACTIC ACIDOSIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; ANIMAL; BREATH ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; URINE;

ANIMALS; BREATH TESTS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICHLOROACETATE; GLYCINE; HIPPURATES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0031596111     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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