In vivo metabolic response of glucose to dichloroacetate in humans

Journal of Surgical Research

Volumn 61, Issue 2, 1996, Pages 391-394

  Brown, Jeff A ^a   Gore, Dennis C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DICHLOROACETIC ACID; GLUCAGON; GLUCOSE; INSULIN; LACTIC ACID;

ADULT; ARTICLE; CALORIMETRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENERGY EXPENDITURE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INTRAVENOUS DRUG ADMINISTRATION; LEG BLOOD FLOW; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; VOLUNTEER;

EID: 0029986507     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0135     Document Type: Article

References (20)

1. Wilmore, D. W. Catabolic illness: Strategies for enhancing recovery. Jeffrey S. Flier, M.D., Lisa H. Underhil (Eds.), Seminars in Medicine from the Beth Israel Hospital, Boston, MA. [Review Article] N. Engl. J. Med. 325(10): 695-702, 1991.
2. Stacpoole, P. W., Moore, G. W., and Kornhauser, D. M. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia. New. Engl. J. Med. 298(10): 526-530, 1978.
3. Carraro, F., Klein, S., Rosenblatt, J. I., and Wolfe, R. R. Effect of dichloroacetate on lactate concentration in exercising humans. J. Appl. Physiol. 66(2): 591-597, 1989.
4. Stacpoole, P. W., Wright, E. C., Baumgartner, T. G., Bersin, R. M., Buchalter, S., Curry, S. H., Duncan, C. A., Harman, E. M., Henderson, G. N., and Jenkinson, S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. New Engl. J. Med. 327(22): 1564-1569, 1992.
5. Whitehouse, S., and Randle, P. J. Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate. Biochem. J. 134: 651-653, 1973.
6. Wells, P. G., Moore, G. W., Rabin, D., Wilkinson, G. R., Oates, J. A., and Stacpoole, P. W. Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans. Diabetologia 19: 109-113, 1980.
7. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine. Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992, pp. 425-426.
8. Morgan, C. R., and Lazano, A. Immunoassay of insulin: Two antibody system. Diabetes 12: 115-126, 1963.
9. Wahren, J., and Jorfeldt, L. Determination of leg blood flow during exercise in man: An indicator-dilution technique based on femoral venous dye infusion. Clin. Sci. and Molec. Med. 45: 135-146, 1973.
10. Gore, D. C., Honeycutt, D., Jahoor, F., Wolfe, R. R., and Herndon, D. N. Effect of exogenous growth hormone on whole body and isolated-limb protein kinetics in burned patients. Arch. Surg. 126: 138-343, 1991.
11. Jequier, E., Acheson, K., and Shutz, Y. Assessment of energy expenditure and fuel utilization in man. Ann. Rev. Nutr. 7: 187-208, 1987.
12. Juhlin-Dannfelt, A., and Astrom, H. Influence of B adrenergic blockade on leg blood flow and lactate release in man. Scand. J. Clin. Lab. Invest. 39: 179-183, 1979.
13. Clark, A. S., Mitch, W. E., Goodman, M. N., Fagan, J. M., Goheer, M. A., and Curnow, R. T. Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle. J. Clin. Invest. 79: 588-594, 1987.
14. Favier, R. J., Koubi, H. E., Mayet, M. H., Sempore, B., Simi, B., and Flandrois, R. Effects of gluconeogenic precursor flux alterations on glycogen resynthesis after prolonged exercise. J. Appl. Physiol. 63(5): 1733-1738, 1987.
15. Holness, M. J., French, T. J., and Sugden, M. C. Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. Biochem. J. 235: 441-445, 1986.
16. Demaugre, F., Cepanec, C., and Leroux, J. P. Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells. Biochem. Biophys. Res. Commun. 85: 1180-1185, 1978.
17. Stacpoole, P. W. Effect of dichloroacetate on gluconeogenesis in isolated rat hepatocytes. Metabolism 26: 107-116, 1976.
18. Diamond, M. P., Williams, P. E., Lacy, W. W., and Cherrington, A. D. Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver. Metabolism 30(9): 880-885, 1981.
19. Wolfe, R. R., Jahoor, F., Herndon, D. N., and Miyoshi, H. Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: Effect of dichloroacetate and glucose infusion. Surgery 110(1): 54-67, 1991.
20. Jahoor, F., Shangraw, R. E., Miyoshi, H., Wallfish, H., Herndon, D. N., and Wolfe, R. R. Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am. J. Physiol. 257:(Endocrinol. Metab. 20): E323-E331, 1989.