CCR5 deficiency induces astrocyte activation, Aβ deposit and impaired memory function

Neurobiology of Learning and Memory

Volumn 92, Issue 3, 2009, Pages 356-363

  Lee, Yong Kyoung ^a   Kwak, Dong Hoon ^a   Oh, Ki Wan ^a   Nam, Sang Yoon ^a   Lee, Beom Jun ^a   Yun, Young Won ^a   Kim, Yun Bae ^a   Han, Sang Bae ^a   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Alzheimer's disease (AD); Amyloid beta (A ); Apoptotic cell death; CC chemokine receptor 2 (CCR2); CC chemokine receptor 5 (CCR5); Memory impairment; Transgenic mouse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR5; GLIAL FIBRILLARY ACIDIC PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; LONG TERM MEMORY; MAZE TEST; MEMORY DISORDER; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PASSIVE AVOIDANCE; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPATIAL MEMORY;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; ASTROCYTES; AVOIDANCE LEARNING; BRAIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; PEPTIDE FRAGMENTS; RECEPTORS, CCR2; RECEPTORS, CCR5; SPACE PERCEPTION;

EID: 69249217778     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nlm.2009.04.003     Document Type: Article

References (38)

1. Bajetto A., Bonavia R., Barbero S., Florio T., and Schettini G. Chemokines and their receptors in the central nervous system. Frontiers in Neuroendocrinology 22 (2001) 147-184
2. Banisadr G., Rostene W., Kitabgi P., and Parsadaniantz S.M. Chemokines and brain functions. Current Drug Targets Inflammation and Allergy 4 (2005) 387-399
3. Busciglio J., Gabuzda D.H., Matsudaira P., and Yankner B.A. Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proceedings of the National Academy of Sciences of the United States of America 90 (1993) 2092-2096
4. Cannella B., and Raine C.S. Multiple sclerosis: Cytokine receptors on oligodendrocytes predict innate regulation. Annals of Neurology 55 (2004) 46-57
5. Chen Z., Yu S., Bakhiet M., Winblad B., and Zhu J. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: Evidence for a compensatory effect by increased CCR2 and CCR3. Journal of Neurochemistry 86 (2003) 61-68
6. Dabir D.V., Robinson M.B., Swanson E., Zhang B., Trojanowski J.Q., Lee V.M., et al. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of Neuroscience 26 (2006) 644-654
7. de Paulis A., Annunziato F., Di Gioia L., Romagnani S., Carfora M., Beltrame C., et al. Expression of the chemokine receptor CCR3 on human mast cells. International Archives of Allergy and Immunology 124 (2001) 146-150
8. Dickson D.W. The pathogenesis of senile plaques. Journal of Neuropathology and Experimental Neurology 56 (1997) 321-339
9. Dorf M.E., Berman M.A., Tanabe S., Heesen M., and Luo Y. Astrocytes express functional chemokine receptors. Journal of Neuroimmunology 111 (2000) 109-121
10. Horuk R., Martin A.W., Wang Z., Schweitzer L., Gerassimides A., Guo H., et al. Expression of chemokine receptors by subsets of neurons in the central nervous system. Journal of Immunology 158 (1997) 2882-2890
11. Ishizuka K., Kimura T., Igata-yi R., Katsuragi S., Takamatsu J., and Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry and Clinical Neurosciences 51 (1997) 135-138
12. Jou I., Lee J.H., Park S.Y., Yoon H.J., Joe E.H., and Park E.J. Gangliosides trigger inflammatory responses via TLR4 in brain glia. The American Journal of Pathology 168 (2006) 1619-1630
13. Kar S., Slowikowski S.P., Westaway D., and Mount H.T. Interactions between beta-amyloid and central cholinergic neurons: Implications for Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences 29 (2004) 427-441
14. Kaul M., Ma Q., Medders K.E., Desai M.K., and Lipton S.A. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death and Differentiation 14 (2007) 296-305
15. Kurt M.A., Davies D.C., and Kidd M. Beta-Amyloid immunoreactivity in astrocytes in Alzheimer's disease brain biopsies: an electron microscope study. Experimental Neurology 158 (1999) 221-228
16. Lahiri D.K., and Greig N.H. Lethal weapon: Amyloid beta-peptide, role in the oxidative stress and neurodegeneration of Alzheimer's disease. Neurobiology of Aging 25 (2004) 581-587
17. LeBlanc A.C., Papadopoulos M., Bélair C., Chu W., Crosato M., Powell J., et al. Processing of amyloid precursor protein in human primary neuron and astrocyte cultures. Journal of Neurochemistry 68 (1997) 1183-1190
18. Letendre S.L., Lanier E.R., and McCutchan J.A. Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1. The Journal of Infectious Diseases 180 (1999) 310-319
19. Morris R. Developments of water-maze procedure for studying spatial learning in the rat. Journal of Neuroscience Methods 11 (1984) 47-60
20. Nagele R.G., D'Andrea M.R., Lee H., Venkataraman V., and Wang H.-Y. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer's disease brains. Brain Research 971 (2003) 197-209
21. Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation. The Journal of Neuroscience 26 (2006) 10129-10140
22. Quinones M.P., Kalkonde Y., Estrada C.A., Jimenez F., Ramirez R., Mahimainathan L., et al. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Molecular and Cellular Neurosciences 37 (2008) 96-109
23. Romagnani S. Cytokines and chemoattractants in allergic inflammation. Molecular Immunology 38 (2002) 881-885
24. Rossner S., Lange-Dohna C., Zeitschel U., and Perez-Polo J.R. Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. Journal of Neurochemistry 92 (2005) 226-234
25. Saez T.E., Pehar M., Vargas M., Barbeito L., and Maccioni R.B. Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In Vivo 18 (2004) 275-280
26. Scheff S.W., and Price D.A. Synaptic density in the inner molecular layer of the hippocampal dentate gyrus in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 57 (1998) 1146-1153
27. Selkoe D. Alzheimer's disease: genes, proteins, and therapy. Physiological Reviews 81 (2001) 741-766
28. Simard A.R., Soulet D., Gowing G., Julien J.P., and Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49 (2006) 489-502
29. Stalder A.K., Ermini F., Bondolfi L., Krenger W., Burbach G.J., Deller T., et al. Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. The Journal of Neuroscience 25 (2005) 11125-11132
30. Tani M., Glabinski A.R., Tuohy V.K., Stoler M.H., Estes M.L., and Ransohoff R.M. In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis. The American Journal of Pathology 148 (1996) 889-896
31. Town T., Laouar Y., Pittenger C., Mori T., Szekely C.A., Tan J., et al. Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature Medicine 14 (2008) 681-687
32. Tzeng S.F., Hsiao H.Y., and Mak O.T. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Current Drug Targets Inflammation and Allergy 4 (2005) 335-340
33. Utsuki T., Yu Q.S., Davidson D., Chen D., Holloway H.W., Brossi A., et al. Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. The Journal of Pharmacology and Experimental Therapeutics 318 (2006) 855-862
34. Van Der Voorn P., Tekstra J., Beelen R.H., Tensen C.P., Van Der Valk P., and De Groot C.J. Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions. The American Journal of Pathology 154 (1999) 45-51
35. Wisneiwski H.M., and Wegiel J. Spatial relationships between astrocytes and classical plaque components. Neurobiology of Aging 12 (1991) 593-600
36. Xia M.Q., Bacskai B.J., Knowles R.B., Qin S.X., and Hyman B.T. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. Journal of Neuroimmunology 108 (2000) 227-235
37. Xia M.Q., and Hyman B.T. Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. Journal of Neurovirology 5 (1999) 32-41
38. Xia M.Q., Qin S.X., Wu L.J., Mackay C.R., and Hyman B.T. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. The American Journal of Pathology 153 (1998) 31-37