Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis

Microbes and Infection

Volumn 11, Issue 12, 2009, Pages 973-979

  Scott, Iain ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Apoptosis; Cardif; Cleavage; Cytomegalovirus; IPS 1; MAVS; RIG I; UL37x1; vMIA

Indexed keywords

CASPASE; CELL PROTEIN; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN VMIA UL37EX1; MAVS PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; VIRUS REPLICATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CYTOMEGALOVIRUS; DEAD-BOX RNA HELICASES; HELA CELLS; HUMANS; IMMEDIATE-EARLY PROTEINS;

AIDS VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 69249215271     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.07.001     Document Type: Article

References (23)

1. Tortorella D., Gewurz B.E., Furman M.H., Schust D.J., and Ploegh H.L. Viral subversion of the immune system. Annu. Rev. Immunol. 18 (2000) 861-926
2. Mocarski E.S. Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends Microbiol. 10 (2002) 332-339
3. Crough T., and Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin. Microbiol. Rev. 22 (2009) 76-98
4. Kotenko S.V., Saccani S., Izotova L.S., Mirochnitchenko O.V., and Pestka S. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10). Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 1695-1700
5. Goldmacher V.S., Bartle L.M., Skaletskaya A., Dionne C.A., Kedersha N.L., Vater C.A., Han J.W., Lutz R.J., Watanabe S., Cahir McFarland E.D., Kieff E.D., Mocarski E.S., and Chittenden T. A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 12536-12541
6. Skaletskaya A., Bartle L.M., Chittenden T., McCormick A.L., Mocarski E.S., and Goldmacher V.S. A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 7829-7834
7. Scott I. Mitochondrial factors in the regulation of innate immunity. Microbes Infect. 11 (2009) 729-736
8. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., and Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5 (2004) 730-737
9. Seth R.B., Sun L., Ea C.K., and Chen Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122 (2005) 669-682
10. Meylan E., Curran J., Hofmann K., Moradpour D., Binder M., Bartenschlager R., and Tschopp J. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437 (2005) 1167-1172
11. Li K., Foy E., Ferreon J.C., Nakamura M., Ferreon A.C.M., Ikeda M., Ray S.C., Gale M., and Lemon S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2992-2997
12. Scott I., and Norris K.L. The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosis. Biochem. Biophys. Res. Commun. 375 (2008) 101-106
13. Rebsamen M., Meylan E., Curran J., and Tschopp J. The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases. Cell Death Differ. 15 (2008) 1804-1811
14. Chen Z., Benureau Y., Rijnbrand R., Yi J., Wang T., Warter L., Lanford R.E., Weinman S.A., Lemon S.M., Martin A., and Li K. GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J. Virol. 81 (2007) 964-976
15. Kovacsovics M., Martinon F., Micheau O., Bodmer J.L., Hofmann K., and Tschopp J. Overexpression of helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr. Biol. 12 (2002) 838-843
16. Barral P.M., Morrison J.M., Drahos J., Gupta P., Sarkar D., Fisher P.B., and Racaniello V.R. MDA-5 is cleaved in poliovirus-infected cells. J. Virol. 81 (2007) 3677-3684
17. Castelli J.C., Hassel B.A., Maran A., Paranjape J., Hewitt J.A., Li X.L., Hsu Y.T., Silverman R.H., and Youle R.J. The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis. Cell Death Differ. 5 (1998) 313-320
18. Domingo-Gil E., and Esteban M. Role of mitochondria in apoptosis induced by the 2-5A system and mechanisms involved. Apoptosis 11 (2006) 725-738
19. Yang Y., Liang Y., Qu L., Chen Z., Yi M., Li K., and Lemon S.M. Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 7253-7258
20. Arnoult D., Bartle L.M., Skaletskaya A., Poncet D., Zamzami N., Park P.U., Sharpe J., Youle R.J., and Goldmacher V.S. Cytomegalovirus cell death suppressor vMIA blocks Bax but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 7988-7993
21. Cheng G., Zhong J., Chung J., and Chisari F.V. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 9035-9040
22. Abate D.A., Watanabe S., and Mocarski E.S. Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. J. Virol. 78 (2004) 10995-11006
23. Yoneyama M., and Fujita T. Function of RIG-I-like receptors in antiviral innate immunity. J. Biol. Chem. 282 (2007) 15315-15318