Lead acetate induces EGFR activation upstream of SFK and PKCα linkage to the Ras/Raf-1/ERK signaling

Toxicology and Applied Pharmacology

Volumn 235, Issue 2, 2009, Pages 244-252

  Wang, Chun Yu ^a   Wang, Yi Ting ^a   Tzeng, Der Wan ^a   Yang, Jia Ling ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

Autophosphorylation; EGFR; Lead acetate; PKC ; Ras Raf 1 ERK; Src

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; ENDOTHELIAL CELL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LEAD ACETATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C ALPHA; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; SMALL INTERFERING RNA; TYROSINE KINASE RECEPTOR;

ARTICLE; AUTOPHOSPHORYLATION; CARCINOMA CELL; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PROTEIN DEPLETION; PROTEIN INDUCTION; STEADY STATE;

BLOTTING, WESTERN; BUTYRIC ACIDS; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, RAS; HUMANS; IMMUNOPRECIPITATION; INDOLES; ORGANOMETALLIC COMPOUNDS; PHENOLS; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; QUINAZOLINES; RAF KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SRC-FAMILY KINASES; SULFONAMIDES; TRANSFECTION;

EID: 60349127816     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.007     Document Type: Article

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