-
1
-
-
36348966706
-
Rho GTPases: Functions and association with cancer
-
Ellenbroek SI and Collard JG: Rho GTPases: functions and association with cancer. Clin Exp Metastasis 24: 657-672, 2007.
-
(2007)
Clin Exp Metastasis
, vol.24
, pp. 657-672
-
-
Ellenbroek, S.I.1
Collard, J.G.2
-
2
-
-
34248210086
-
Rho activation at a glance
-
Buchsbaum RJ: Rho activation at a glance. J Cell Sci 120: 1149-1152, 2007.
-
(2007)
J Cell Sci
, vol.120
, pp. 1149-1152
-
-
Buchsbaum, R.J.1
-
3
-
-
13444252631
-
GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
-
DOI 10.1038/nrm1587
-
Rossman KL, Der CJ and Sondek J: GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180, 2005. (Pubitemid 40215811)
-
(2005)
Nature Reviews Molecular Cell Biology
, vol.6
, Issue.2
, pp. 167-180
-
-
Rossman, K.L.1
Der, C.J.2
Sondek, J.3
-
4
-
-
34247175312
-
GTP-binding proteins of the Rho/Rac family: Regulation, effectors and functions in vivo
-
DOI 10.1002/bies.20558
-
Bustelo XR, Sauzeau V and Berenjeno IM: GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays 29: 356-370, 2007. (Pubitemid 46597867)
-
(2007)
BioEssays
, vol.29
, Issue.4
, pp. 356-370
-
-
Bustelo, X.R.1
Sauzeau, V.2
Berenjeno, I.M.3
-
5
-
-
0034025493
-
Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters
-
Kazanietz MG: Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol Carcinog 28: 5-11, 2000.
-
(2000)
Mol Carcinog
, vol.28
, pp. 5-11
-
-
Kazanietz, M.G.1
-
6
-
-
34147138401
-
Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac
-
DOI 10.1042/BJ20061750
-
Yang C and Kazanietz MG: Chimaerins: GAPs that bridge diacyl-glycerol signalling and the small G-protein Rac. Biochem J 1: 1-12, 2007. (Pubitemid 46569861)
-
(2007)
Biochemical Journal
, vol.403
, Issue.1
, pp. 1-12
-
-
Yang, C.1
Kazanietz, M.G.2
-
7
-
-
0038375063
-
Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain
-
Menna PL, Skilton G, Leskow FC, Alonso DF, Gomez DE and Kazanietz MG: Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain. Cancer Res 63: 2284-2291, 2003. (Pubitemid 36538638)
-
(2003)
Cancer Research
, vol.63
, Issue.9
, pp. 2284-2291
-
-
Menna, P.L.1
Skilton, G.2
Leskow, F.C.3
Alonso, D.F.4
Gomez, D.E.5
Kazanietz, M.G.6
-
8
-
-
34347369084
-
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
-
Konstantinopoulos PA, Karamouzis MV and Papavassiliou AG: Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat Rev Drug Discov 6: 541-555, 2007.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 541-555
-
-
Konstantinopoulos, P.A.1
Karamouzis, M.V.2
Papavassiliou, A.G.3
-
9
-
-
0036239832
-
HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis
-
DOI 10.1038/sj/leu/2402476
-
Wong WW, Dimitroulakos J, Minden MD and Penn LZ: HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16: 508-519, 2002. (Pubitemid 34460459)
-
(2002)
Leukemia
, vol.16
, Issue.4
, pp. 508-519
-
-
Wong, W.W.-L.1
Dimitroulakos, J.2
Minden, M.D.3
Penn, L.Z.4
-
10
-
-
0033529171
-
1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
-
DOI 10.1073/pnas.96.14.7797
-
Rao S, Porter DC, Chen X, Herliczek T, Lowe M and Keyomarsi K: Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 96: 7797-7802, 1999. (Pubitemid 29328361)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.14
, pp. 7797-7802
-
-
Rao, S.1
Porter, D.C.2
Chen, X.3
Herliczek, T.4
Lowe, M.5
Keyomarsi, K.6
-
11
-
-
0036395370
-
Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells
-
Farina HG, Bublik DR, Alonso DF and Gomez DE: Lovastatin alters cytoskeleton organization and inhibits experimental metastasis of mammary carcinoma cells. Clin Exp Metastasis 19: 551-559, 2002.
-
(2002)
Clin Exp Metastasis
, vol.19
, pp. 551-559
-
-
Farina, H.G.1
Bublik, D.R.2
Alonso, D.F.3
Gomez, D.E.4
-
12
-
-
0029785179
-
Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma
-
DOI 10.1002/(SICI)1096-9098(199608)62:4<288::AID-JSO14>3.0.CO;2-1
-
Alonso DF, Farias EF, Urtreger A, Ladeda V, Vidal MC and Bal de Kier Joffe E: Characterization of F3II, a mammary sarcomatoid carcinoma cell line originated from a mouse adenocarcinoma. J Surg Oncol 62: 288-297, 1996. (Pubitemid 26262354)
-
(1996)
Journal of Surgical Oncology
, vol.62
, Issue.4
, pp. 288-297
-
-
Alonso, D.F.1
Farias, E.F.2
Urtreger, A.3
Ladeda, V.4
Vidal, M.D.C.C.5
Bal De Kier Joffe, E.6
-
13
-
-
0003747871
-
Current protocols in immunology
-
Coico R (ed). John Wiley & Sons Inc., New York, NY
-
Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM and Strober W: Current protocols in immunology. In: Related Isolation Procedures and Functional Assays. Vol 1. Coico R (ed). John Wiley & Sons Inc., New York, NY, 1995.
-
(1995)
Related Isolation Procedures and Functional Assays
, vol.1
-
-
Coligan, J.E.1
Kruisbeek, A.M.2
Margulies, D.H.3
Shevach, E.M.4
Strober, W.5
-
14
-
-
0031784485
-
Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
-
DOI 10.1023/A:1006058409974
-
Alonso DF, Farina HG, Skilton G, Gabri MR, De Lorenzo MS and Gomez DE: Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res Treat 50: 83-93, 1998. (Pubitemid 28438864)
-
(1998)
Breast Cancer Research and Treatment
, vol.50
, Issue.1
, pp. 83-93
-
-
Alonso, D.F.1
Farina, H.G.2
Skilton, G.3
Gabri, M.R.4
De Lorenzo, M.S.5
Gomez, D.E.6
-
15
-
-
0242464926
-
+ T lymphocytes
-
+ T lymphocytes. J Clin Invest 111: 1133-1145, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1133-1145
-
-
Tiede, I.1
Fritz, G.2
Strand, S.3
Poppe, D.4
Dvorsky, R.5
Strand, D.6
Lehr, H.A.7
Wirtz, S.8
Becker, C.9
Atreya, R.10
Mudter, J.11
Hildner, K.12
Bartsch, B.13
Holtmann, M.14
Blumberg, R.15
Walczak, H.16
Iven, H.17
Galle, P.R.18
Ahmadian, M.R.19
Neurath, M.F.20
more..
-
16
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB and Hall A: Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269, 2005.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
17
-
-
38449123547
-
Role of Rho GTPases in breast cancer
-
DOI 10.2741/2718
-
Tang Y, Olufemi L, Wang MT and Nie D: Role of Rho GTPases in breast cancer. Front Biosci 1: 759-776, 2008. (Pubitemid 351599780)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.2
, pp. 759-776
-
-
Tang, Y.1
Olufemi, L.2
Wang, M.-T.3
Nie, D.4
-
19
-
-
0031935592
-
Mas oncogene signaling and transformation require the small GTP-binding protein Rac
-
Zohn IE, Symons M, Chrzanowska-Wodnicka M, Westwick JK and Der CJ: Mas oncogene signaling and transformation require the small GTP-binding protein Rac. Mol Cell Biol 18: 1225-1235, 1998. (Pubitemid 28100886)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.3
, pp. 1225-1235
-
-
Zohn, I.E.1
Symons, M.2
Chrzanowska-Wodnicka, M.3
Westwick, J.K.4
Der, C.J.5
-
20
-
-
0037142034
-
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
-
DOI 10.1038/nature00848
-
Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F and Collard JG: Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature 417: 867-871, 2002. (Pubitemid 34670335)
-
(2002)
Nature
, vol.417
, Issue.6891
, pp. 867-871
-
-
Malliri, A.1
Van Der Kammen, R.A.2
Clark, K.3
Van Der Valk, M.4
Michiels, F.5
Collard, J.G.6
-
21
-
-
0034602690
-
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
-
DOI 10.1073/pnas.97.1.185
-
Mira JP, Benard V, Groffen J, Sanders LC and Knaus UG: Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci USA 47: 185-189, 2000. (Pubitemid 30055805)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.1
, pp. 185-189
-
-
Mira, J.-P.1
Benard, V.2
Groffen, J.3
Sanders, L.C.4
Knaus, U.G.5
-
22
-
-
0034659739
-
Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
-
Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, Harbeck N, Schmitt M and Lengyel E: Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19: 3013-3020, 2000. (Pubitemid 30389092)
-
(2000)
Oncogene
, vol.19
, Issue.26
, pp. 3013-3020
-
-
Schnelzer, A.1
Prechtel, D.2
Knaus, U.3
Dehne, K.4
Gerhard, M.5
Graeff, H.6
Harbeck, N.7
Schmitt, M.8
Lengyel, E.9
-
23
-
-
0141449134
-
Statin inhibition of HMG-CoA reductase: A 3-dimensional view
-
Istvan E: Statin inhibition of HMG-CoA reductase: a 3-dimensional view. Atheroscler Suppl 4: 3-8, 2003.
-
(2003)
Atheroscler Suppl
, vol.4
, pp. 3-8
-
-
Istvan, E.1
-
24
-
-
45549091043
-
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and ravastatin
-
Neuvogen PJ, Backman JT and Niemi M: Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and ravastatin. Clin Pharmacokinet 47: 463-474, 2008.
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 463-474
-
-
Neuvogen, P.J.1
Backman, J.T.2
Niemi, M.3
-
25
-
-
33644781781
-
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
-
DOI 10.1124/jpet.105.094136
-
Thelen KM, Rentsch KM, Gutteck U, Heverin M, Olin M, Andersson U, von Eckardstein A, Björkhem I and Lütjohann D: Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin. J Pharmacol Exp Ther 316: 1146-1152, 2006. (Pubitemid 43345288)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.316
, Issue.3
, pp. 1146-1152
-
-
Thelen, K.M.1
Rentsch, K.M.2
Gutteck, U.3
Heverin, M.4
Olin, M.5
Andersson, U.6
Von Eckardstein, A.7
Bjorkhem, I.8
Lutjohann, D.9
-
26
-
-
0029101360
-
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
-
Olson MF, Ashwort A and Hall A: An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272, 1995.
-
(1995)
Science
, vol.269
, pp. 1270-1272
-
-
Olson, M.F.1
Ashwort, A.2
Hall, A.3
-
27
-
-
0036098594
-
Rho GTPase signalling pathways in the morphological changes associated with apoptosis
-
DOI 10.1038/sj/cdd/4400987
-
Coleman M and Olson MF: Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ 9: 493-504, 2002. (Pubitemid 34521177)
-
(2002)
Cell Death and Differentiation
, vol.9
, Issue.5
, pp. 493-504
-
-
Coleman, M.L.1
Olson, M.F.2
-
28
-
-
0035958923
-
Rac1 Protects Epithelial Cells against Anoikis
-
DOI 10.1074/jbc.M102299200
-
Coniglio SJ, Jou TS and Symons M: Rac1 protects epithelial cells against anoikis. J Biol Chem 276: 28113-28120, 2001. (Pubitemid 37391512)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.30
, pp. 28113-28120
-
-
Coniglio, S.J.1
Jou, T.-S.2
Symons, M.3
-
29
-
-
0034601013
-
The GTPase Rho controls a p53-dependent survival checkpoint during thymopoiesis
-
DOI 10.1084/jem.192.1.77
-
Costello PS, Cleverley SC, Galandrini R, Henning SW and Cantrell DA: The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J Exp Med 192: 77-85, 2000. (Pubitemid 30470808)
-
(2000)
Journal of Experimental Medicine
, vol.192
, Issue.1
, pp. 77-85
-
-
Costello, P.S.1
Cleverley, S.C.2
Galandrini, R.3
Henning, S.W.4
Cantrell, D.A.5
-
30
-
-
29644444216
-
Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on rac proteins
-
Poppe D, Tiede I, Fritz G, Becker C, Bartsch B, Wirtz S, Strand D, Tanaka S, Galle PR, Bustelo XR and Neurath MF: Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol 176: 640-651, 2006. (Pubitemid 43023313)
-
(2006)
Journal of Immunology
, vol.176
, Issue.1
, pp. 640-651
-
-
Poppe, D.1
Tiede, I.2
Fritz, G.3
Becker, C.4
Bartsch, B.5
Wirtz, S.6
Strand, D.7
Tanaka, S.8
Galle, P.R.9
Bustelo, X.R.10
Neurath, M.F.11
|