Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development

Endocrinology

Volumn 150, Issue 9, 2009, Pages 4024-4032

  Naja, Roy Pascal ^a,b   Dardenne, Olivier ^a,c   Arabian, Alice ^a   St Arnaud, René ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; COMPLEMENTARY DNA; CYP27B1 ENZYME; CYTOCHROME; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE CELL; CELL MATURATION; CONTROLLED STUDY; GROWTH PLATE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BONE AND BONES; CALCIFEDIOL; CALCITRIOL; CALCIUM; CELL DIFFERENTIATION; CHONDROCYTES; FEMALE; GROWTH PLATE; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOGENESIS;

EID: 69249113528     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1410     Document Type: Article

References (27)

1. DeLuca HF 2004 Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80:1689S-1696S
2. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW 1998 The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13:325-349
3. Zehnder D, Bland R, Walker EA, Bradwell AR, Howie AJ, Hewison M, Stewart PM 1999 Expression of 25-hydroxyvitamin D3-1α-hydroxylase in the human kidney. J Am Soc Nephrol 10:2465-2473
4. Miller WL, Portale AA 2000 Vitamin D 1α-hydroxylase. Trends Endocrinol Metab 11:315-319
5. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL 2006 Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770-1773
6. Zasloff M 2006 Fighting infections with vitamin D. Nat Med 12:388-390
7. Boivin G, Mesguich P, Pike JW, Bouillon R, Meunier PJ, Haussler MR, Dubois PM, Morel G 1987 Ultrastructural immunocytochemical localization of endogenous 1,25-dihydroxyvitamin D3 and its receptors in osteoblasts and osteocytes from neonatal mouse and rat calvaria. Bone Miner 3:125-136
8. Johnson JA, Grande JP, Roche PC, Kumar R 1996 Ontogeny of the 1,25-dihydroxyvitamin D3 receptor in fetal rat bone. J Bone Miner Res 11:56-61
9. Narbaitz R, Stumpf WE, Sar M, Huang S, DeLuca HF 1983 Autoradiographic localization of target cells for 1α,25-dihydroxyvitamin D3 in bones from fetal rats. Calcif Tissue Int 35:177-182
10. Masuyama R, Stockmans I, Torrekens S, Van Looveren R, Maes C, Carmeliet P, Bouillon R, Carmeliet G 2006 Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 116:3150-3159
11. Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R 2001 Targeted inactivation of the 25-hydroxyvitamin D(3)-1α-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141
12. Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R 2003 Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162:139-148
13. St-Arnaud R, Dardenne O, Prud'homme J, Hacking SA, Glorieux FH 2003 Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1). J Cell Biochem 88:245-251
14. Niederreither K, D'Souza RN, de Crombrugghe B 1992 Minimal DNA sequences that control the cell lineage-specific expression of the pro α2(I) collagen promoter in transgenic mice. J Cell Biol 119:1361-1370
15. Tuckermann JP, Pittois K, Partridge NC, Merregaert J, Angel P 2000 Collagenase-3 (MMP-13) and integral membrane protein 2a (Itm2a) are marker genes of chondrogenic/osteoblastic cells in bone formation: sequential temporal, and spatial expression of Itm2a, alkaline phosphatase, MMP-13, and osteocalcin in the mouse. J Bone Miner Res 15:1257-1265
16. Saito H, Kusano K, Kinosaki M, Ito H, Hirata M, Segawa H, Miyamoto K, Fukushima N 2003 Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1α,25-dihydroxyvitamin D3 production. J Biol Chem 278:2206-2211
17. Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y 1997 Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro. J Bone Miner Res 12:1174-1188
18. Haddad Jr JG, Boisseau V, Avioli LV 1971 Placental transfer of vitamin D3 and 25-hydroxycholecalciferol in the rat. J Lab Clin Med 77:908-915
19. Takamoto M, Tsuji K, Yamashita T, Sasaki H, Yano T, Taketani Y, Komori T, Nifuji A, Noda M 2003 Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-κB ligand (RANKL) gene expression in chondrocytes. J Endocrinol 177:413-421
20. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB 1997 Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835
21. Dardenne O, Prud'homme J, Hacking SA, Glorieux FH, St-Arnaud R 2003 Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1). Bone 32:332-340
22. Kovacs CS, Kronenberg HM 1997 Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18:832-872
23. Labrie F, Luu-The V, Lin SX, Simard J, Labrie C, El-Alfy M, Pelletier G, Bélanger A 2000 Intracrinology: role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease. J Mol Endocrinol 25:1-16
24. St-Jacques B, Hammerschmidt M, McMahon AP 1999 Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086
25. Ingham PW 2001 Hedgehog signaling: a tale of two lipids. Science 294:1879-1881
26. Murakami S, Nifuji A, Noda M 1997 Expression of Indian hedgehog in osteoblasts and its posttranscriptional regulation by transforming growth factor-beta. Endocrinology 138:1972-1978
27. Lin R, Amizuka N, Sasaki T, Aarts MM, Ozawa H, Goltzman D, Henderson JE, White JH 2002 1α,25-Dihydroxyvitamin D3 promotes vascularization of the chondro-osseous junction by stimulating expression of vascular endothelial growth factor and matrix metalloproteinase 9. J Bone Miner Res 17:1604-1612