Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1)

Journal of Cellular Biochemistry

Volumn 88, Issue 2, 2003, Pages 245-251

  St Arnaud, René ^a,b   Dardenne, Olivier ^a   Prud'homme, Josée ^a   Hacking, S Adam ^b   Glorieux, Francis H ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Knockout; PDDR; Rickets; Vitamin D hydroxylase

Indexed keywords

25 HYDROXYVITAMIN D 1ALPHA HYDROXYLASE; CALCITRIOL; CALCIUM; COLLAGEN TYPE 2; CRE RECOMBINASE; ION; LACTOSE; MINERAL; OXYGENASE; PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOMECHANICS; BLOOD CHEMISTRY; BONE; CALCIUM INTAKE; CARTILAGE CELL; CELL FUNCTION; CELL MATURATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INACTIVATION; GENE EXPRESSION; GENE MUTATION; GROWTH PLATE; HOMOZYGOTE; HYPOCALCEMIA; KIDNEY; KNOCKOUT MOUSE; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RICKETS; SECONDARY HYPERPARATHYROIDISM; TISSUE SPECIFICITY; TRANSGENIC MOUSE; VITAMIN D DEPENDENT RICKETS TYPE 1;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BIOMECHANICS; BONE AND BONES; CALCITRIOL; CALCIUM CHANNEL AGONISTS; CALCIUM, DIETARY; CHONDROCYTES; GROWTH PLATE; HYPERPARATHYROIDISM; HYPOCALCEMIA; HYPOPHOSPHATEMIA; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; OSTEOMALACIA; RICKETS;

ANIMALIA;

EID: 0037304076     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10348     Document Type: Conference Paper

References (36)

1. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. 1999. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses. Endocrinology 140:4982-4987.
2. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. 1986. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 63:954-959.
3. Boyan BD, Schwartz Z, Carnes DL, Jr., Ramirez V. 1988. The effects of vitamin D metabolites on the plasma and matrix vesicle membranes of growth and resting cartilage cells in vitro. Endocrinology 122:2851-2860.
4. Boyan BD, Dean DD, Sylvia VL, Schwartz Z. 1997. Genomic and nongenomic regulation by 1,25(OH)2D3 and 24,25(OH)2D3. Cartilage and vitamin D. In: Feldman D, Glorieux FH, Pike JW, editors. Vitamin D. San Diego: Academic Press. pp 395-422.
5. Boyan BD, Sylvia VL, Dean DD, Pedrozo H, Del F, Nemere I, Posner GH, Schwartz Z. 1999. 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids 64:129-136.
6. Brunette MG, Chan M, Ferriere C, Roberts KD. 1978. Site of 1,25(OH)2 vitamin D3 synthesis in the kidney. Nature 276:287-289.
7. Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St R. 2001. Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141.
8. Delvin EE, Glorieux FH, Marie PJ, Pettifor JM. 1981. Vitamin D dependency: Replacement therapy with calcitriol. J Pediatr 99:26-34.
9. Dickson GR. 1984. Methods of calcified tissue preparation. New York, NY: Elsevier.
10. Feldman D, Glorieux FH, Pike JW. 1997. Vitamin D. San Diego: Academic Press.
11. Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA. 1997a. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol 11: 1961-1970.
12. Fu GK, Portale AA, Miller WL. 1997b. Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha. DNA Cell Biol 16:1499-1507.
13. Gascon-Barré M. 1997. The vitamin D 25-hydroxylase. In: Feldman D, Glorieux FH, Pike JW, editors. Vitamin D. San Diego: Academic Press. pp 41-55.
14. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW. 1998. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Miner Res 13:325-349.
15. Heaney RP. 1997. Vitamin D: Role in the calcium economy. In: Feldman D, Glorieux FH, Pike JW, editors. Vitamin D. San Diego: Academic Press. pp 485-498.
16. Hewison M, O'Riordan JLH. 1997. Immunomodulatory and cell differentiation effects of vitamin D. In: Feldman L, Glorieux FH, Pike JW, editors. Vitamin D. San Diego: Academic Press. pp 447-462.
17. Holick MF. 1997. Photobiology of vitamin. D In: Feldman D, Glorieux FH, Pike JW, editors. Vitamin D. San Diego: Academic Press. pp 33-39.
18. Lewandoski M. 2001. Conditional control of gene expression in the mouse. Nat Rev Genet 2:743-755.
19. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB. 1997. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94: 9831-9835.
20. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. 1998. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139: 4391-4396.
21. Long F, Zhang XM, Karp S, Yang Y, McMahon AP. 2001. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-5108.
22. Malloy PJ, Pike JW, Feldman D. 1999. The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev 20:156-188.
23. Marie PJ, Travers R, Glorieux FH. 1982. Healing of bone lesions with 1,25-dihydroxyvitamin D3 in the young X-linked hypophosphatemic male mouse. Endocrinology 111:904-911.
24. Miller WL, Portale AA. 2000. Vitamin D 1alpha-hydroxylase. Trends Endocrinol Metab 11:315-319.
25. Pedrozo HA, Boyan BD, Mazock J, Dean DD, Gomez R, Schwartz Z. 1999a. TGFbetal regulates 25-hydroxyvitamin D3 1alpha-and 24-hydroxylase activity in cultured growth plate chondrocytes in a maturation-dependent manner. Calcif Tissue Int 64:50-56.
26. Pedrozo HA, Schwartz Z, Rimes S, Sylvia VL, Nemere I, Posner GH, Dean DD, Boyan BD. 1999b. Physiological importance of the 1,25(OH)2D3 membrane receptor and evidence for a membrane receptor specific for 24,25(OH)2D3. J Bone Miner Res 14:856-867.
27. Portale AA, Miller WL. 2000. Human 25-hydroxyvitamin D-1alpha-hydroxylase: Cloning, mutations, and gene expression. Pediatr Nephrol 14:620-625.
28. Reichel H, Bishop JE, Koeffler HP, Norman AW. 1991. Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages. Mol Cell Endocrinol 75:163-167.
29. Schipani E, Ryan HE, Didrickson S, Kobayashi T, Knight M, Johnson RS. 2001. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15:2865-2876.
30. Schwartz Z, Dean D, Walton J, Brooks B, Boyan B. 1995. Treatment of resting zone chondrocytes with 24,25-dihydroxyvitamin D3 [24,25-(OH)2D3] induces differentiation into a 1,25-(OH)2D3-responsive phenotype characteristic of growth zone chondrocytes. Endocrinology 136:402-411.
31. Schwartz Z, Pedrozo HA, Sylvia VL, Gomez R, Dean DD, Boyan BD. 2001. 1alpha,25-(OH)2D3 regulates 25-hydro xyvitamin D3 24R-hydroxylase activity in growth zone costochondral growth plate chondrocytes via protein kinase C. Calcif Tissue Int 69:365-372.
32. St-Arnaud R, Glorieux FH. 2000. Hereditary defects in vitamin D metabolism and action. In: DeGroot LJ, Jameson JL, editors. Endocrinology. Vol. 2. Fourth Edition. Philadelphia: W.B. Saunders Company. pp 1154-1168.
33. St-Arnaud R, Messerlian S, Moir JM, Omdahl JL, Glorieux FH. 1997. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J Bone Miner Res 12:1552-1559.
34. Turner RT, Puzas JE, Forte MD, Lester GE, Gray TK, Howard GA, Baylink DJ. 1980. In vitro synthesis of 1 alpha,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells. Proc Natl Acad Sci USA 77:5720-5724.
35. Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, Carmeliet G. 2001. Duodenal calcium absorption in vitamin D receptor-knockout mice: Functional and molecular aspects. Proc Natl Acad Sci USA 98:13324-13329.
36. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia, and growth retardation after weaning. Nat Genet 16:391-396.