Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22166-22172

  Umeda, Mayumi ^a   Murata Kamiya, Naoko ^a   Saito, Yasuhiro ^a   Ohba, Yusuke ^b   Takahashi, Masayuki ^a   Hatakeyama, Masanori ^a,c  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; CHROMOSOMAL INSTABILITY; CHRONIC EXPOSURE; DUAL FUNCTION; GASTRIC CARCINOMA; GASTRIC EPITHELIAL CELLS; GENE PRODUCTS; HELICOBACTER PYLORI; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE STABILITY; MICROTUBULES; MIS-ORIENTATION; MITOTIC DELAY; MITOTIC SPINDLE; MULTI-STEP; ONCOPROTEINS; RISK FACTORS;

CELL PROLIFERATION; STABILITY;

CELL MEMBRANES;

CAGA PROTEIN; PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 KINASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL DIVISION; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CONTROLLED STUDY; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; INHIBITION KINETICS; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROPHASE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA;

ANAPHASE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; GENETIC VECTORS; HELICOBACTER PYLORI; HUMANS; METAPHASE; MICROSCOPY, VIDEO; MICROTUBULES; MITOSIS; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; TRANSFECTION;

HELICOBACTER PYLORI;

EID: 69249104165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.035766     Document Type: Article

References (48)

1. Marshall, B. J., and Warren, J. R. (1984) Lancet 1, 1311-1315
2. Covacci, A., Censini, S., Bugnoli, M., Petracca, R., Burroni, D., Macchia, G., Massone, A., Papini, E., Xiang, Z., Figura, N., and Rappuoli, R. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 5791-5795
3. Tummuru, M. K., Cover, T. L., and Blaser, M. J. (1993) Infect. Immun. 61, 1799-1809
4. Tomb, J. F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E. F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H. G., Glodek, A., McKenney, K., Fitzegerald, L. M., Lee, N., Adams, M. D., Hickey, E. K., Berg, D. E., Gocayne, J. D., Utterback, T. R., Peterson, J. D., Kelley, J. M., Cotton, M. D., Weidman, J. M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W. S., Borodovsky, M., Karp, P. D., Smith, H. O., Fraser, C. M., and Venter, J. C. (1997) Nature 388, 539-547
5. Covacci, A., Telford, J. L., Del Giudice, G., Parsonnet, J., and Ruppuoli, R. (1999) Science 284, 1328-1333
6. Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L., Peek, R. M., Chyou, P. H., Stemmermann, G. N., and Nomura, A. (1995) Cancer Res. 55, 2111-2115
7. Parsonnet, J., Friedman, G. D., Orentreich, N., and Vogelman, H. (1997) Gut 40, 297-301
8. Rugge, M., Busatto, G., Cassaro, M., Shiao, Y. H., Russo, V., Leandro, G., Avellini, C., Fabiano, A., Sidoni, A., and Covacci, A. (1999) Cancer 85, 2506-2511
9. Rudi, J., Kolb, C., Maiwald, M., Zuna, I., vov Herbay, A., Galle, P. R., and Stremmel, W. (1997) Dig. Dis. Sci. 42, 1652-1659
10. Torres, J., Pérez-Pérez, G. I., Leal-Herrera, Y., and Muñoz, O. (1998) Int. J. Cancer 78, 298-300
11. Shimoyama, T., Fukuda, S., Tanaka, M., Mikami, T., Munakata, A., and Crabtree, J. E. (1998) J. Clin. Pathol. 51, 225-228
12. Nomura, A. M., Lee, J., Stemmermann, G. N., Nomura, R. Y., Pérez-Pérez, G. I., and Blaser, M. J. (2002) J. Infect. Dis 186, 1138-1144
13. Segal, E. D., Cha, J., Lo, J., Falkow, S., and Tompkins, L. S. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 14559-14564
14. Odenbreit, S., Püls, J., Sedlmaier, B., Gerland, E., Fischer, W., and Haas, R. (2000) Science 287, 1497-1500
15. Stein, M., Bagnoli, F., Halenbeck, R., Rappuoli, R., Fantl, W. J., and Covacci, A. (2002) Mol. Microbiol. 43, 971-980
16. Backert, S., Moese, S., Selbach, M., Brinkmann, V., and Meyer, T. F. (2001) Mol. Microbiol. 42, 631-644
17. Poppe, M., Feller, S. M., Römer, G., and Wessler, S. (2007) Oncogene 26, 3462-3472
18. Higashi, H., Tsutsumi, R., Muto, S., Sugiyama, T., Azuma, T., Asaka, M., and Hatakeyama, M. (2002) Science 295, 683-686
19. Higashi, H., Tsutsumi, R., Fujita, A., Yamazaki, S., Asaka, M., Azuma, T., and Hatakeyama, M. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 14428-14433
20. Yamazaki, S., Yamakawa, A., Ito, Y., Ohtani, M., Higashi, H., Hatakeyama, M., and Azuma, T. (2003) J. Infect. Dis. 187, 334-337
21. Hatakeyama, M. (2004) Nat. Rev. Cancer 4, 688-694
22. Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., Yamada, G., Azuma, T., and Hatakeyama, M. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 1003-1008
23. Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., and Falkow, S. (2003) Science 300, 1430-1434
24. Bagnoli, F., Buti, L., Tompkins, L., Covacci, A., and Amieva, M. R. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 16339-16344
25. Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S., and Hatakeyama, M. (2007) Nature 447, 330-333
26. Lu, H. S., Saito, Y., Umeda, M., Murata-Kamiya, N., Zhang, H. M., Higashi, H., and Hatakeyama, M. (2008) Cancer Sci. 99, 2004-2011
27. Kemphues, K. J., Priess, J. R., Morton, D. G., and Cheng, N. S. (1988) Cell 52, 311-320
28. Watts, J. L., Etemad-Moghadam, B., Guo, S., Boyd, L., Draper, B. W., Mello, C. C., Priess, J. R., and Kemphues, K. J. (1996) Development. 122, 3133-3140
29. Suzuki, A., Hirata, M., Kamimura, K., Maniwa, R., Yamanaka, T., Mizuno, K., Kishikawa, M., Hirose, H., Amano, Y., Izumi, N., Miwa, Y., and Ohno, S. (2004) Curr. Biol. 14, 1425-1435
30. Macara, I. G. (2004) Nat. Rev. Mol. Cell Biol. 5, 220-231
31. Hurov, J. B., Watkins, J. L., and Piwnica-Worms, H. (2004) Curr. Biol. 14, 736-741
32. Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E. M., and Mandelkow, E. (1997) Cell 89, 297-308
33. Ebneth, A., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1999) Cell Motil. Cytoskeleton 44, 209-224
34. Vandré, D. D., Centonze, V. E., Peloquin, J., Tombes, R. M., and Borisy, G. G. (1991) J. Cell Sci. 98, 577-588
35. Preuss, U., Doring, F., Illenberger, S., and Mandelkow, E. M. (1995) Mol. Biol. Cell 6, 1397-1410
36. Saxton, W. M., Stemple, D. L., Leslie, R. J., Salmon, E. D., Zavortink, M., and Mclntosh, J. R. (1984) J. Cell Biol. 99, 2175-2186
37. Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R. M., Jr., Azuma, T., and Hatakeyama, M. (2007) Oncogene 26, 4617-4626
38. Izumi, M., Miyazawa, H., Kamakura, T., Yamaguchi, I., Endo, T., and Hanaoka, F. (1991) Exp. Cell Res. 197, 229-233
39. Kanda, T., Sullivan, K. F., and Wahl, G. M. (1998) Curr. Biol. 8, 377-385
40. Storchova, Z., and Pellman, D. (2004) Nat. Rev. Mol. Cell Biol. 5, 45-54
41. Kops, G. J., Weaver, B. A., and Cleveland, D. W. (2005) Nat. Rev. Cancer 5, 773-785
42. Musacchio, A., and Salmon, E. D. (2007) Nat. Rev. Mol. Cell Biol. 8, 379-393
43. Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J. B., and Bornens, M. (2005) Nat. Cell Biol. 7, 947-953
44. Toyoshima, F., and Nishida, E. (2007) EMBO J. 26, 1487-1498
45. Varmark, H. (2004) J. Cell Biochem. 91, 904-914
46. Toyoshima, F., Matsumura, S., Morimoto, H., Mitsushima, M., and Nishida, E. (2007) Dev. Cell 13, 796-811
47. Wu, G., Lin, Y. T., Wei, R., Chen, Y., Shan, Z., and Lee, W. H. (2008) Mol. Cell Biol. 28, 3652-3662
48. Weaver, B. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., and Cleveland, D. W. (2007) Cancer Cell 11, 25-36