Cyclic RGD-targeting of reversibly stabilized DNA nanoparticles enhances cell uptake and transfection in vitro

Journal of Drug Targeting

Volumn 17, Issue 5, 2009, Pages 364-373

  Zhou, Qing Hui ^a   You, Ye Zi ^a,b   Wu, Chao ^a   Huang, Yi ^a   Oupický, David ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Gene delivery; Gene therapy; HPMA; Real time PCR; RGD; Tumor targeting

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CD51 ANTIGEN; COPOLYMER; DNA; DNA POLYPLEX; N (2 HYDROXYPROPYL)METHACRYLAMIDE; NANOPARTICLE; POLYELECTROLYTE; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; CYCLIC ARGININE GLYCINE ASPARTIC ACID PEPTIDE; CYCLIC ARGININE-GLYCINE-ASPARTIC ACID PEPTIDE; CYCLOPEPTIDE; N-(2-HYDROXYPROPYL)METHACRYLAMIDE;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CELL INTERACTION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STABILITY; DRUG TARGETING; ENDOTHELIUM CELL; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; MELANOMA CELL; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; UMBILICAL VEIN; ZETA POTENTIAL; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; GENE TRANSFER; METABOLISM; METHODOLOGY; POLYMERASE CHAIN REACTION;

ACRYLAMIDES; ANIMALS; CELL LINE; CELL SURVIVAL; DNA; DRUG STABILITY; GENE TRANSFER TECHNIQUES; HUMANS; INTEGRIN ALPHAV; MICE; NANOPARTICLES; PEPTIDES, CYCLIC; POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 69149106068     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860902807046     Document Type: Article

References (46)

1. Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, and Facchiano A. (2004). RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells. Blood, 103, 4180-4187.
2. Arap W, Pasqualini R, Ruoslahti E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 279, 377-380.
3. Aris A, Villaverde A. (2000). Molecular organization of protein-DNA complexes for cell-targeted DNA delivery. Biochem Biophys Res Commun, 278, 455-461.
4. Baillie CT, Winslet MC, Bradley NJ. (1995). Tumour vasculature-a potential therapeutic target. Br J Cancer, 72, 257-267.
5. Baranska P, Jerczynska H, Pawlowska Z, Koziolkiewicz W, Cierniewski CS. (2005). Expression of integrins and adhesive properties of human endothelial cell line EA.hy 926. Cancer Genomics Proteomics, 2, 265-270.
6. Brenner W, Gross S, Steinbach F, Horn S, Hohenfellner R, Thuroff JW. (2000). Differential inhibition of renal cancer cell invasion mediated by fibronectin, collagen IV and laminin. Cancer Lett, 155, 199-205.
7. Bronich TK, Nguyen HK, Eisenberg A, Kabanov AV. (2000). Recognition of DNA topology in reactions between plasmid DNA and cationic copolymers. J Am Chem Soc, 122, 8339-8343.
8. Burak Y, Ariel G, Andelman D. (2003). Onset of DNA aggregation in presence of monovalent and multivalent counterions. Biophys J, 85, 2100-2110.
9. Clements BA, Bai J, Kucharski C, Farrell LL, Lavasanifar A, Ritchie B, Ghahary A, Uludag H. (2006). RGD conjugation to polyethyleneimine does not improve DNA delivery to bone marrow stromal cells. Biomacromolecules, 7, 1481-1488.
10. Colin M, Harbottle RP, Knight A, Kornprobst M, Cooper RG, Miller AD, Trugnan G, Capeau J, Coutelle C, Brahimi-Horn MC. (1998). Liposomes enhance delivery and expression of an RGDoligolysine gene transfer vector in human tracheal cells. Gene Ther, 5, 1488-1498.
11. Dash PR, Read ML, Fisher KD, Howard KA, Wolfert M, Oupicky D, Subr V, Strohalm J, Ulbrich K, Seymour LW. (2000). Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. J Biol Chem, 275, 3793-3802.
12. Enns A, Korb T, Schluter K, Gassmann P, Spiegel HU, Senninger N, Mitjans F, Haier J. (2005). Alphavbeta5-integrins mediate early steps of metastasis formation. Eur J Cancer, 41, 1065-1072.
13. Harvie P, Dutzar B, Galbraith T, Cudmore S, O'Mahony D, Anklesaria P, Paul R. (2003). Targeting of lipid-protamine-DNA (LPD) lipopolyplexes using RGD motifs. J Liposome Res, 13, 231-247.
14. Haubner R, Wester HJ, Burkhart F, Senekowitsch-Schmidtke R, Weber W, Goodman SL, Kessler H, Schwaiger M. (2001). Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med, 42, 326-336.
15. Houk BE, Hochhaus G, Hughes JA. (1999). Kinetic modeling of plasmid DNA degradation in rat plasma. AAPS PharmSci, 1, E9.
16. Houk BE, Martin R, Hochhaus G, Hughes JA. (2001). Pharmacokinetics of plasmid DNA in the rat. Pharm Res, 18, 67-74.
17. Hynes RO. (2002). Integrins: bidirectional, allosteric signaling machines. Cell, 110, 673-687.
18. Kim S, Bell K, Mousa SA, Varner JA. (2000). Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cellbinding domain of fibronectin. Am J Pathol, 156, 1345-1362.
19. Kim WJ, Yockman JW, Lee M, Jeong JH, Kim YH, Kim SW. (2005). Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. J Control Release, 106, 224-234.
20. Kunath K, Merdan T, Hegener O, Haberlein H, Kissel T. (2003). Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J Gene Med, 5, 588-599.
21. Lai E, Van Zanten JH. (2001). Monitoring DNA/poly-l-lysine polyplex formation with time-resolved multiangle laser light scattering. Biophys J, 80, 864-873.
22. Lang SH, Clarke NW, George NJ, Testa NG. (1997). Primary prostatic epithelial cell binding to human bone marrow stroma and the role of alpha2beta1 integrin. Clin Exp Metastasis, 15, 218-227.
23. Mayoral R, Fernandez-Martinez A, Bosca L, Martin-Sanz P. (2005). Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells. Carcinogenesis, 26, 753-761.
24. Meerovitch K, Bergeron F, Leblond L, Grouix B, Poirier C, Bubenik M, Chan L, Gourdeau H, Bowlin T, Attardo G. (2003). A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen. Vascul Pharmacol, 40, 77-89.
25. Mitra A, Mulholland J, Nan A, McNeill E, Ghandehari H, Line BR. (2005). Targeting tumor angiogenic vasculature using polymer- RGD conjugates. J Control Release, 102, 191-201.
26. Niven R, Pearlman R, Wedeking T, MacKeigan J, Noker P, Simpson- Herren L, Smith JG. (1998). Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice. J Pharm Sci, 87, 1292-1299. (Pubitemid 28514130)
27. Oba M, Fukushima S, Kanayama N, Aoyagi K, Nishiyama N, Koyama H, and Kataoka K. (2007). Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins. Bioconjug Chem, 18, 1415-1423.
28. Osaka G, Carey K, Cuthbertson A, Godowski P, Patapoff T, Ryan A, Gadek T, Mordenti J. (1996). Pharmacokinetics, tissue distribution, and expression efficiency of plasmid [33P]DNA following intravenous administration of DNA/cationic lipid complexes in mice: use of a novel radionuclide approach. J Pharm Sci, 85, 612-618.
29. Oupicky D, Howard KA, Konak C, Dash PR, Ulbrich K, Seymour LW. (2000). Steric stabilization of poly-l-lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl) methacrylamide]. Bioconjug Chem, 11, 492-501.
30. Oupicky D, Ogris M, Howard KA, Dash PR, Ulbrich K, Seymour LW. (2002a). Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther, 5, 463-472.
31. Oupicky D, Parker AL, Seymour LW. (2002b). Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors. J Am Chem Soc, 124, 8-9.
32. Pan H, Zheng Q, Guo X, Liu Y, Li C, Song Y. (2006). A RGD-containing oligopeptide (K)16GRGDSPC: a novel vector for integrin-mediated targeted gene delivery. J Huazhong Univ Sci Technol Med Sci, 26, 513-516.
33. Ray S, Chattopadhyay N, Biswas N, Chatterjee A. (1999). Regulatory molecules in tumor metastasis. J Environ Pathol Toxicol Oncol, 18, 251-259.
34. Rokhlin OW, Cohen MB. (1995). Expression of cellular adhesion molecules on human prostate tumor cell lines. Prostate, 26, 205-212.
35. Romanov VI, Goligorsky MS. (1999). RGD-recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro. Prostate, 39, 108-118.
36. Ruoslahti E. (2002). Specialization of tumour vasculature. Nat Rev Cancer, 2, 83-90.
37. Ruponen M, Yla-Herttuala S, Urtti A. (1999). Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. Biochim Biophys Acta, 1415, 331-341.
38. Schiffelers RM, Ansari A, Xu J, Zhou Q, Tang Q, Storm G, Molema G, Lu PY, Scaria PV, Woodle MC. (2004). Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res, 32, e149.
39. Shiras A, Bhosale A, Patekar A, Shepal V, Shastry P. (2002). Differential expression of CD44(S) and variant isoforms v3, v10 in threedimensional cultures of mouse melanoma cell lines. Clin Exp Metastasis, 19, 445-455.
40. Smolarczyk R, Cichon T, Graja K, Hucz J, Sochanik A, Szala S. (2006). Antitumor effect of RGD-4C-GG-D(KLAKLAK)2 peptide in mouse B16(F10) melanoma model. Acta Biochim Pol, 53, 801-805.
41. Soundara Manickam D, Bisht HS, Wan L, Mao G, Oupicky D. (2005). Influence of TAT-peptide polymerization on properties and transfection activity of TAT/DNA polyplexes. J Control Release, 102, 293-306.
42. Suh W, Han SO, Yu L, Kim SW. (2002). An angiogenic, endothelialcell- targeted polymeric gene carrier. Mol Ther, 6, 664-672.
43. Ustach CV, Taube ME, Hurst NJ Jr, Bhagat S, Bonfil RD, Cher ML, Schuger L, Kim HR. (2004). A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progression. Cancer Res, 64, 1722-1729.
44. Varga CM, Hong K, Lauffenburger DA. (2001). Quantitative analysis of synthetic gene delivery vector design properties. Mol Ther, 4, 438-446.
45. Wiethoff CM, Smith JG, Koe GS, Middaugh CR. (2001). The potential role of proteoglycans in cationic lipid-mediated gene delivery. Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans. J Biol Chem, 276, 32806-32813.
46. Zhou QH, Miller DL, Carlisle RC, Seymour LW, Oupicky D. (2005). Ultrasound-enhanced transfection activity of HPMA-stabilized DNA polyplexes with prolonged plasma circulation. J Control Release, 106, 416-427.