Targeting of Lipid-Protamine-DNA (LPD) Lipopolyplexes Using RGD Motifs

Journal of Liposome Research

Volumn 13, Issue 3-4, 2003, Pages 231-247

  Harvie, Pierrot ^a,c   Dutzar, Benjamin ^a,d   Galbraith, Todd ^a   Cudmore, Sally ^b,e   O'Mahony, Daniel ^b   Anklesaria, Pervin ^a   Paul, Ralph ^a  

^a Targeted Genetics Corporation   (United States)

^b ELAN PHARMACEUTICALS   (United States)

^c Celator Technologies Inc   (Canada)

^d Nastech Pharmaceutical Company Inc   (United States)

^e UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Gene therapy; Lipid protamine DNA (LPD); RGD; Tumor targeting

Indexed keywords

1,2 DISTERAOYLGLYCERO 3 PHOSPHOETHANOLAMINE N [METHOXY(POLYETHYLENE GLYCOL)]; 1,2 DISTERAOYLGLYCERO 3 PHOSPHOETHANOLAMINE N [METHOXY(POLYETHYLENE GLYCOL)]SUCCINYLALANYLCYSTEINYLGLUTAMINYLCYSTEINYLARGINYLGLYCYLASPARTYLCYSTEINYL PHENYLALANYLCYSTEINYLGLYCINE CARBOXYLIC ACID; ARGINYLGLYCYLASPARTIC ACID; DNA; INTEGRIN; INTEGRIN RECEPTOR; LIGAND; LIPID; MACROGOL; PHOSPHOLIPID; PROTAMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CONJUGATE; CONTROLLED STUDY; DRUG FORMULATION; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TRANSPORT; TUMOR CELL;

EID: 0345283215     PISSN: 08982104     EISSN: None     Source Type: Journal    
DOI: 10.1081/LPR-120026389     Document Type: Article

References (32)

1. Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 1996; 35:1027-1036.
2. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 1997; 4:891-900.
3. Li S, Rizzo MA, Bhattacharya S, Huang L. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Ther 1998; 5(7):930-937.
4. Li S, Tseng W-C, Beer Stolz D, Wu S-P, Watkins SC, Huang L. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene Ther 1999; 6:585-594.
5. Harvie P, Wong FM, Bally MB. Characterization of lipid DNA interactions. I. Destabilization of bound lipids and DNA dissociation. Biophys J 1998; 75(2):1040-1051.
6. Zelphati O, Szoka FC Jr. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci USA 1996; 593:11493-11498.
7. Xu Y, Szoka FC Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996; 35(18):5616-5623.
8. Liu Y, Mounkes LC, Liggitt HD, Brown CS, Solodin I, Heath TD, Debs RJ. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nature Biotech 1997; 15(2):167-173.
9. Zhu N, Liggitt D, Liu Y, Debs R. Systematic gene expression after intravenous DNA delivery into adult mice. Science 1993; 261:209-211.
10. Lasic DD. Novel applications of liposomes. Trends in Biotech 1998; 16(7):307-321.
11. Needham D, Stoicheva N, Zhelev DV. Exchange of monooleoylphosphatidylcholine as monomer and micelle with membranes containing poly(ethylene glycol)lipid. Biophys J 1997; 73(5):2615-2629.
12. Anwer K, Kao G, Proctor B, Rolland A, Sullivan S. Optimization of cationic lipid/DNA complexes for systemic gene transfer to tumor lesions. J Drug Targeting 2000; 8(2):125-135.
13. Harvie P, Wong FM, Bally MB. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J Pharm Sci 2000; 89(5):652-663.
14. Mok KWC, Lam AMI, Cullis PR. Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochim et Biophys Acta 1999; 1419(2):137-150.
15. Zhang YP, Sekirov L, Saravolac EG, Wheeler JJ, Tardi P, Clow K, Leng E, Sun R, Cullis PR, Scherrer P. Stabilized plasmid-lipid particles for regional gene therapy: formulation and transfection properties. Gene Ther 1999; 6(8):1438-1447.
16. Kirpotin D, Hong K, Mullah N, Papahadjopoulos D, Zalipsky S. Liposomes with detachable polymer coating: destabilization fusion of dioleoylphosphattidylethanolamine vesicles triggered by cleavage of surfacegrafted poly(ethylene glycol). FEBS Lett 1997; 388:115-118.
17. Kichler A, Frish B, Lima de Souza D, Schuber F. Receptor-mediated gene delivery with nonviral DNA carriers. J Lipo Res 2000; 10(4):443-460.
18. Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 1998; 279(5349): 377-380.
19. Pasqualini R, Koivunen E, Ruoslahti E. Alpha v integrins as receptors for tumor targeting by circulating ligands. Nature Biotech 1997; 15(6):542-546.
20. Fortunati E, Ehlert E, van Loo ND, Wyman C, Eble JA, Grosveld F, Scholte BJ. A multi-domain protein for beta1 integrin-targeted DNA delivery. Gene Ther 2000; 7(17):1505-1515.
21. Aoki Y, Hosaka S, Kawa S, Kiyosawa K. Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif. Cancer Gene Ther 2001; 8(10):783-787.
22. Muller K, Nahde T, Fahr A, Muller R, Brusselbach S. Highly efficient transduction of endothelial cells by targeted artificial virus-like particles. Cancer Gene Ther 2001; 8(2):107-117.
23. Scott ES, Wiseman JW, Evans MJ, Colledge WH. Enhanced gene delivery to human airway epithelial cells using an integrin-targeting lipoplex. J Gene Med 2001; 3(2):125-134.
24. Uduehi N, Moss SH, Nutatall J, Pouton C. Cationic lipid-mediated transfection of differentiated Caco-2 cells: a filter culture model of gene delivery to a polarized epithelium. Pharm Res 1999; 16:1805-1811.
25. Hood JD, Bednarski M, Frausto R, Guccione S, Reisfeld RA, Xiang R, Cheresh DA. Tumor regression by targeted gene delivery to the neovasculature. Science 2002; 296(5577):2404-2407.
26. Shi W, Arnold GS, Bartlett JS. Insertional mutagenesis of the adeno-associated virus type 2 (aav2) capsid gene and generation of aav2 vectors targeted to alternative cell-surface receptors. Hum Gene Ther 2001; 12(14):1697-1711.
27. Grill J, Van Beusechem VW, Van Der Valk P, Dirven CM, Leonhart A, Pherai DS, Haisma HJ, Pinedo HM, Curiel DT, Gerritsen WR. Combined targeting of adenoviruses to integrins and epidermal growth factor receptors increases gene transfer into primary glioma cells and spheroids. Clin Cancer Res 2001; 7(3):641-650.
28. Pool GL, French ME, Edwards RA, Huang L, Lumb RH. Use of radiolabeled hexadecyl cholesteryl ether as a liposome marker. Lipids 1982; 17(6):448-452.
29. Mounkes LC, Zhong W, Ciprespalacin G, Heath TD, Debs RJ. Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J of Bio Chem 1998; 273(40):26164-26170.
30. Maruyama K, Ishida O, Takizawa T, Moribe K. Possibility of active targeting to tumor tissues with liposomes. Adv Drug Del Rev 1999; 40:89-102.
31. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A 1998; 95(8):4607-4612.
32. Li WM, Xue L, Mayer LD, Bally MB. Intermembrane transfer of polyethylene glycol-modified phosphatidylethanolamine as a means to reveal surface-associated binding ligands on liposomes. Biochim Biophys Acta 2001; 1513(2):193-206.