-
1
-
-
0028822481
-
Chronic lymphocytic leukemia
-
Rozman, C. E. Montserrat. 1995. Chronic lymphocytic leukemia. N. Engl. J. Med. 333 : 1052 1057.
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 1052-1057
-
-
Rozman, C.1
Montserrat, E.2
-
2
-
-
0242298176
-
Role of the microenvironment in chronic lymphocytic leukemia
-
Caligaris-Cappio, F. 2003. Role of the microenvironment in chronic lymphocytic leukemia. Br. J. Hematol. 123 : 380 388.
-
(2003)
Br. J. Hematol.
, vol.123
, pp. 380-388
-
-
Caligaris-Cappio, F.1
-
3
-
-
0035353212
-
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
-
Granziero, L. et al. 2001. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 97 : 2777 2783.
-
(2001)
Blood
, vol.97
, pp. 2777-2783
-
-
Granziero, L.1
-
4
-
-
20044372326
-
In vivo measurements document the dynamic, cellular kinetics of chronic lymphocytic B cells
-
Messmer, B.T. et al. 2005. In vivo measurements document the dynamic, cellular kinetics of chronic lymphocytic B cells. J. Clin. Invest. 115 : 755 764.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 755-764
-
-
Messmer, B.T.1
-
6
-
-
0029990349
-
B-chronic lymphocytic leukemia: A malignancy of anti-self B cells
-
Caligaris-Cappio, F. 1996. B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 87 : 2615 2620.
-
(1996)
Blood
, vol.87
, pp. 2615-2620
-
-
Caligaris-Cappio, F.1
-
7
-
-
0034523170
-
Update on the biology of chronic lymphocytic leukemia
-
Bannerji, R. J.C. Byrd. 2000. Update on the biology of chronic lymphocytic leukemia. Curr. Opin. Oncol. 12 : 22 29.
-
(2000)
Curr. Opin. Oncol.
, vol.12
, pp. 22-29
-
-
Bannerji, R.1
Byrd, J.C.2
-
8
-
-
2342661714
-
Treatment of chronic lymphocytic leukemia
-
Ferrajoli, A. S.M. O'Brien. 2004. Treatment of chronic lymphocytic leukemia. Semin. Oncol. 31 : 60 65.
-
(2004)
Semin. Oncol.
, vol.31
, pp. 60-65
-
-
Ferrajoli, A.1
O'Brien, S.M.2
-
9
-
-
20444389401
-
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
-
Petlickovski, A. et al. 2005. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 105 : 4820 4827.
-
(2005)
Blood
, vol.105
, pp. 4820-4827
-
-
Petlickovski, A.1
-
10
-
-
33644825118
-
Old and new insight into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: Fludarabine and cladribine
-
Van Den Neste, E. et al. 2005. Old and new insight into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine. Int. J. Oncol. 27 : 1113 1124.
-
(2005)
Int. J. Oncol.
, vol.27
, pp. 1113-1124
-
-
Van Den Neste, E.1
-
11
-
-
34548128321
-
Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: Clinical correlation
-
Rodriguez, A. et al. 2007. Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation. Leukemia 21 : 1984 1991.
-
(2007)
Leukemia
, vol.21
, pp. 1984-1991
-
-
Rodriguez, A.1
-
12
-
-
11144316653
-
Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells
-
Hahntow, I.N. et al. 2004. Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells. Leukemia 18 : 747 755.
-
(2004)
Leukemia
, vol.18
, pp. 747-755
-
-
Hahntow, I.N.1
-
13
-
-
0347416908
-
Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
-
Saxena, A. et al. 2004. Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia. Am. Hematol. 75 : 22 33.
-
(2004)
Am. Hematol.
, vol.75
, pp. 22-33
-
-
Saxena, A.1
-
14
-
-
16444375702
-
Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia
-
Packham, G. F.K. Stevenson. 2005. Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology 114 : 441 449.
-
(2005)
Immunology
, vol.114
, pp. 441-449
-
-
Packham, G.1
Stevenson, F.K.2
-
15
-
-
1242295307
-
Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells
-
Sanz, L. et al. 2004. Bcl-2 family gene modulation during spontaneous apoptosis of B-chronic lymphocytic leukemia cells. Biochim. Biophys. Res. Commun. 315 : 562 567.
-
(2004)
Biochim. Biophys. Res. Commun.
, vol.315
, pp. 562-567
-
-
Sanz, L.1
-
16
-
-
2042436415
-
Expression of cyclin e in resting and activated B-chronic lymphocytic leukaemia cells: Cyclin E/cdk2 as a potential therapeutic target
-
Decker, T. et al. 2004. Expression of cyclin E in resting and activated B-chronic lymphocytic leukaemia cells: cyclin E/cdk2 as a potential therapeutic target. Br. J. Hematol. 125 : 141 148.
-
(2004)
Br. J. Hematol.
, vol.125
, pp. 141-148
-
-
Decker, T.1
-
17
-
-
21144435503
-
A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down regulation of genes involved in transcription regulation and survival
-
Alvi, A.J. et al. 2005. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down regulation of genes involved in transcription regulation and survival. Blood 105 : 4484 4491.
-
(2005)
Blood
, vol.105
, pp. 4484-4491
-
-
Alvi, A.J.1
-
18
-
-
20444477948
-
Seliciclib (Cyc202, R-roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
-
MacCallum, D.E. et al. 2005. Seliciclib (Cyc202, R-roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res. 65 : 5399 5407.
-
(2005)
Cancer Res.
, vol.65
, pp. 5399-5407
-
-
MacCallum, D.E.1
-
19
-
-
29844452101
-
Dual action of the inhibitors of cyclin-dependent kinases: Targeting of the cell-cycle progression and activation of wild-type p53 protein
-
Wesierska-Gadek, J. G. Schmid. 2006. Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. Expert Opin. Investig. Drugs 15 : 23 38.
-
(2006)
Expert Opin. Investig. Drugs
, vol.15
, pp. 23-38
-
-
Wesierska-Gadek, J.1
Schmid, G.2
-
20
-
-
15944377427
-
Alemtuzumab in the treatment of chronic lymphocytic leukemia
-
Robak, T. 2005. Alemtuzumab in the treatment of chronic lymphocytic leukemia. BioDrugs 19 : 9 22.
-
(2005)
BioDrugs
, vol.19
, pp. 9-22
-
-
Robak, T.1
-
21
-
-
27644467899
-
Rituximab plus purine nucleoside analogs in the treatment of indolent lymphoid malignancies
-
Robak, T. 2005. Rituximab plus purine nucleoside analogs in the treatment of indolent lymphoid malignancies. Am. J. Cancer 4 : 279 292.
-
(2005)
Am. J. Cancer
, vol.4
, pp. 279-292
-
-
Robak, T.1
-
22
-
-
16444375191
-
Chronic lymphocytic leukemia
-
Byrd, J.C. et al. 2004. Chronic lymphocytic leukemia. Hematology Am. Soc. Educ. Program 2004 : 163 183.
-
(2004)
Hematology Am. Soc. Educ. Program
, vol.2004
, pp. 163-183
-
-
Byrd, J.C.1
-
23
-
-
34047190281
-
Management of symptomatic, untreated lymphocytic leukemia
-
Kasamon, Y.L. J.W. Flinn. 2007. Management of symptomatic, untreated lymphocytic leukemia. Blood Rev. 21 : 143 156.
-
(2007)
Blood Rev.
, vol.21
, pp. 143-156
-
-
Kasamon, Y.L.1
Flinn, J.W.2
-
24
-
-
0031840834
-
Cladribine for the treatment of hairy cell leukemia and chronic lymphocytic leukemia
-
Rai, K.R. 1998. Cladribine for the treatment of hairy cell leukemia and chronic lymphocytic leukemia. Semin. Oncol. 25 (suppl. 7 19 22.
-
(1998)
Semin. Oncol.
, vol.25
, Issue.7
, pp. 19-22
-
-
Rai, K.R.1
-
25
-
-
0242583769
-
Combination strategies for purine nucleoside analogs
-
B.D. Cheson. Ed.: Marcel Dekker. Basel, New York.
-
Gandhi, V. W. Plunkett. 2001. Combination strategies for purine nucleoside analogs. In Chronic Lymphocytic Leukemias. B.D. Cheson, Ed. : 195 208. Marcel Dekker. Basel, New York.
-
(2001)
Chronic Lymphocytic Leukemias
, pp. 195-208
-
-
Gandhi, V.1
Plunkett, W.2
-
26
-
-
33744802581
-
Chronic lymphocytic leukemia (CLL): First-line treatment
-
Hallek, M. 2005. Chronic lymphocytic leukemia (CLL): first-line treatment. Hematology Am. Soc. Educ. Program 2005 : 285 291.
-
(2005)
Hematology Am. Soc. Educ. Program
, vol.2005
, pp. 285-291
-
-
Hallek, M.1
-
27
-
-
2142650988
-
Biology and treatment of chronic lymphocytic leukemia
-
Keating, M. J. et al. 2003. Biology and treatment of chronic lymphocytic leukemia. Hematology Am. Soc. Educ. Program 2003 : 153 175.
-
(2003)
Hematology Am. Soc. Educ. Program
, vol.2003
, pp. 153-175
-
-
Keating, M.J.1
-
28
-
-
9644279545
-
2-chlorodeoxyadenosine alone and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo
-
Rogalinska, M. et al. 2004. 2-chlorodeoxyadenosine alone and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo. Cancer Detect. Prev. 28 : 433 442.
-
(2004)
Cancer Detect. Prev.
, vol.28
, pp. 433-442
-
-
Rogalinska, M.1
-
29
-
-
12744279711
-
Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells
-
Smolewski, P. et al. 2005. Proapoptotic activity of alemtuzumab alone and in combination with rituximab or purine nucleoside analogues in chronic lymphocytic leukemia cells. Leuk. Lymphoma 46 : 87 100.
-
(2005)
Leuk. Lymphoma
, vol.46
, pp. 87-100
-
-
Smolewski, P.1
-
30
-
-
33846820580
-
Correlation of ZAP-70 expression in B-cell leukemias to the ex vivo response to a combination of fludarabine-genistein
-
Mansour, A. et al. 2007. Correlation of ZAP-70 expression in B-cell leukemias to the ex vivo response to a combination of fludarabine-genistein. Cancer Immunol. Immunother. 56 : 501 514.
-
(2007)
Cancer Immunol. Immunother.
, vol.56
, pp. 501-514
-
-
Mansour, A.1
-
31
-
-
0016740933
-
Clinical staging of chronic lymphocytic leukemia
-
Rai, K.R. et al. 1975. Clinical staging of chronic lymphocytic leukemia. Blood 46 : 219 234.
-
(1975)
Blood
, vol.46
, pp. 219-234
-
-
Rai, K.R.1
-
32
-
-
0032830965
-
In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia
-
Bellosillo, B. et al. 1999. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94 : 2836 2843.
-
(1999)
Blood
, vol.94
, pp. 2836-2843
-
-
Bellosillo, B.1
-
33
-
-
39049189036
-
In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combination with mafosfamide and/or mitoxantrone
-
Kobylińska, A. et al. 2006. In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combination with mafosfamide and/or mitoxantrone. Oncol. Rep. 16 : 1389 1395.
-
(2006)
Oncol. Rep.
, vol.16
, pp. 1389-1395
-
-
Kobylińska, A.1
-
34
-
-
71849104860
-
Protein measurement with the Folin phenol reagent
-
Lowry, O.H. et al. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 : 265 275.
-
(1951)
J. Biol. Chem.
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
-
35
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 : 680 685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
36
-
-
0009482260
-
Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
-
Towbin, H. et al. 1979. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76 : 4350 4354.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 4350-4354
-
-
Towbin, H.1
-
37
-
-
0020794694
-
Rapid and sensitive colorimetric method for visualizing biotin-labelled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: Bio-blots
-
Leary, J.J. et al. 1983. Rapid and sensitive colorimetric method for visualizing biotin-labelled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: bio-blots. Proc. Natl. Acad. Sci. USA 80 : 4045 4049.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 4045-4049
-
-
Leary, J.J.1
-
38
-
-
0030832602
-
+ leukemic B cells; In vitro/in vivo correlations
-
+ leukemic B cells; in vitro/in vivo correlations. Br. J. Haematol. 99 : 147 157.
-
(1997)
Br. J. Haematol.
, vol.99
, pp. 147-157
-
-
Gottardi, D.1
-
39
-
-
0031829418
-
In vitro chemosensitivity of chronic lymphocytic leukemia to purine analogues - Correlation with clinical course
-
Bromidge, T.J. et al. 1998. In vitro chemosensitivity of chronic lymphocytic leukemia to purine analogues - correlation with clinical course. Leukemia 12 : 1230 1235.
-
(1998)
Leukemia
, vol.12
, pp. 1230-1235
-
-
Bromidge, T.J.1
-
40
-
-
0032079746
-
Expression of apoptosis - Regulating proteins in chronic lymphocytic leukemia: Correlation with in vitro and in vivo chemoresponses
-
Kitada, S. et al. 1998. Expression of apoptosis - regulating proteins in chronic lymphocytic leukemia: correlation with in vitro and in vivo chemoresponses. Blood 91 : 379 389.
-
(1998)
Blood
, vol.91
, pp. 379-389
-
-
Kitada, S.1
-
41
-
-
0035283079
-
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
-
Wieder, T. et al. 2001. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 97 : 1378 1387.
-
(2001)
Blood
, vol.97
, pp. 1378-1387
-
-
Wieder, T.1
-
42
-
-
0028176483
-
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
-
Polyak, K. et al. 1994. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78 : 59 66.
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak, K.1
-
43
-
-
0034660892
-
The Pezcoller lecture: Cancer cell cycles revisited
-
Sherr, C.J. 2000. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. 60 : 3689 3695.
-
(2000)
Cancer Res.
, vol.60
, pp. 3689-3695
-
-
Sherr, C.J.1
-
44
-
-
0036121523
-
Proteolytic cleavage of cyclin e leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells
-
Mazumder, S. et al. 2002. Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells. Mol. Cell. Biol. 22 : 2398 2409.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2398-2409
-
-
Mazumder, S.1
-
45
-
-
0033606960
-
Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity
-
Eymin, B. et al. 1999. Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity. Oncogene 18 : 4839 4847.
-
(1999)
Oncogene
, vol.18
, pp. 4839-4847
-
-
Eymin, B.1
-
46
-
-
0037058678
-
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
-
McClue S.J. et al. 2002. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int. J. Cancer 102 : 463 468.
-
(2002)
Int. J. Cancer
, vol.102
, pp. 463-468
-
-
McClue, S.J.1
-
47
-
-
0034812298
-
The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382
-
Liungman, M. 2001. The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol. Pharmacol. 60 : 785 789.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 785-789
-
-
Liungman, M.1
-
48
-
-
19044371037
-
Recent progress in the discovery and development of cyclin-dependent kinase inhibitors
-
Fischer, P. M. A. Gianella-Borradori. 2005. Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opin. Investig. Drugs 14 : 4547 4577.
-
(2005)
Expert Opin. Investig. Drugs
, vol.14
, pp. 4547-4577
-
-
Fischer, P.M.1
Gianella-Borradori, A.2
-
49
-
-
0037665145
-
Roscovitine and other purines as kinase inhibitors. from starfish oocytes to clinical trials
-
Meijer, L. E. Maymond. 2003. Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc. Chem. Res. 36 : 417 425.
-
(2003)
Acc. Chem. Res.
, vol.36
, pp. 417-425
-
-
Meijer, L.1
Maymond, E.2
-
50
-
-
40849142330
-
Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo
-
McClue, S.J. I. Stuart. 2008. Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo. Drug Metab. Dispos. 36 : 561 570.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 561-570
-
-
McClue, S.J.1
Stuart, I.2
|