메뉴 건너뛰기




Volumn 21, Issue 3, 2007, Pages 143-156

Management of symptomatic, untreated chronic lymphocytic leukemia

Author keywords

Alemtuzumab; Chronic lymphocytic leukemia (CLL); Fludarabine; Rituximab

Indexed keywords

ALEMTUZUMAB; CHLORAMBUCIL; CLADRIBINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUDARABINE; PENTOSTATIN; PREDNISONE; RITUXIMAB; VINCRISTINE;

EID: 34047190281     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.blre.2006.10.001     Document Type: Article
Times cited : (6)

References (84)
  • 1
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment
    • Cheson B.D., Bennett J.M., Grever M., et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 87 (1996) 4990-4997
    • (1996) Blood. , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3
  • 2
    • 0025239350 scopus 로고    scopus 로고
    • Effects of chlorambucil and therapeutic decision in initial forms of chronic lymphocytic leukemia (stage A): results of a randomized clinical trial on 612 patients. The French Cooperative Group on Chronic Lymphocytic Leukemia. Blood. 1990;75:1414-1421.
  • 3
    • 0033583824 scopus 로고    scopus 로고
    • Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. CLL Trialists' Collaborative Group. J Natl Cancer Inst. 1999;91:861-868.
  • 4
    • 33646477111 scopus 로고    scopus 로고
    • Autoimmune complications of chronic lymphocytic leukemia
    • Hamblin T.J. Autoimmune complications of chronic lymphocytic leukemia. Semin Oncol. 33 (2006) 230-239
    • (2006) Semin Oncol. , vol.33 , pp. 230-239
    • Hamblin, T.J.1
  • 5
    • 0021270274 scopus 로고
    • Bone marrow histologic pattern-the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases
    • Rozman C., Montserrat E., Rodriguez-Fernandez J.M., et al. Bone marrow histologic pattern-the best single prognostic parameter in chronic lymphocytic leukemia: a multivariate survival analysis of 329 cases. Blood. 64 (1984) 642-648
    • (1984) Blood. , vol.64 , pp. 642-648
    • Rozman, C.1    Montserrat, E.2    Rodriguez-Fernandez, J.M.3
  • 6
    • 0023618027 scopus 로고
    • Prognostic value of the lymphocyte doubling time in chronic lymphocytic leukemia
    • Molica S., and Alberti A. Prognostic value of the lymphocyte doubling time in chronic lymphocytic leukemia. Cancer. 60 (1987) 2712-2716
    • (1987) Cancer. , vol.60 , pp. 2712-2716
    • Molica, S.1    Alberti, A.2
  • 7
    • 0029829395 scopus 로고    scopus 로고
    • Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma
    • Hallek M., Wanders L., Ostwald M., et al. Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma. Leuk Lymphoma. 22 (1996) 439-447
    • (1996) Leuk Lymphoma. , vol.22 , pp. 439-447
    • Hallek, M.1    Wanders, L.2    Ostwald, M.3
  • 8
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H., Fischer K., Bentz M., et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood. 85 (1995) 1580-1589
    • (1995) Blood. , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3
  • 9
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H., Stilgenbauer S., Benner A., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 343 (2000) 1910-1916
    • (2000) N Engl J Med. , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 10
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • Krober A., Seiler T., Benner A., et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 100 (2002) 1410-1416
    • (2002) Blood. , vol.100 , pp. 1410-1416
    • Krober, A.1    Seiler, T.2    Benner, A.3
  • 11
    • 4143105617 scopus 로고    scopus 로고
    • ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia
    • Rassenti L.Z., Huynh L., Toy T.L., et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med. 351 (2004) 893-901
    • (2004) N Engl J Med. , vol.351 , pp. 893-901
    • Rassenti, L.Z.1    Huynh, L.2    Toy, T.L.3
  • 12
    • 0022347576 scopus 로고
    • Treatment of chronic lymphocytic leukemia in advanced stages. A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone
    • Montserrat E., Alcala A., Parody R., et al. Treatment of chronic lymphocytic leukemia in advanced stages. A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone. Cancer. 56 (1985) 2369-2375
    • (1985) Cancer. , vol.56 , pp. 2369-2375
    • Montserrat, E.1    Alcala, A.2    Parody, R.3
  • 13
    • 0022514522 scopus 로고
    • Treatment of chronic lymphocytic leukemia using chlorambucil and prednisone with or without cycle-active consolidation chemotherapy. A Southeastern Cancer Study Group Trial
    • Keller J.W., Knospe W.H., Raney M., et al. Treatment of chronic lymphocytic leukemia using chlorambucil and prednisone with or without cycle-active consolidation chemotherapy. A Southeastern Cancer Study Group Trial. Cancer 58 (1986) 1185-1192
    • (1986) Cancer , vol.58 , pp. 1185-1192
    • Keller, J.W.1    Knospe, W.H.2    Raney, M.3
  • 14
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai K.R., Peterson B.L., Appelbaum F.R., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 343 (2000) 1750-1757
    • (2000) N Engl J Med. , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 15
    • 0017730147 scopus 로고
    • Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia
    • Sawitsky A., Rai K.R., Glidewell O., and Silver R.T. Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia. Blood. 50 (1977) 1049-1059
    • (1977) Blood. , vol.50 , pp. 1049-1059
    • Sawitsky, A.1    Rai, K.R.2    Glidewell, O.3    Silver, R.T.4
  • 16
    • 0025231329 scopus 로고    scopus 로고
    • A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. The French Cooperative Group on Chronic Lymphocytic Leukemia. Blood. 1990;75:1422-1425.
  • 17
    • 0025910992 scopus 로고
    • Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: long-term follow-up of an Eastern Cooperative Oncology Group randomized clinical trial
    • Raphael B., Andersen J.W., Silber R., et al. Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: long-term follow-up of an Eastern Cooperative Oncology Group randomized clinical trial. J Clin Oncol. 9 (1991) 770-776
    • (1991) J Clin Oncol. , vol.9 , pp. 770-776
    • Raphael, B.1    Andersen, J.W.2    Silber, R.3
  • 18
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • Leporrier M., Chevret S., Cazin B., et al. Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood. 98 (2001) 2319-2325
    • (2001) Blood. , vol.98 , pp. 2319-2325
    • Leporrier, M.1    Chevret, S.2    Cazin, B.3
  • 19
    • 0026015638 scopus 로고
    • Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia
    • Keating M.J., Kantarjian H., O'Brien S., et al. Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia. J Clin Oncol. 9 (1991) 44-49
    • (1991) J Clin Oncol. , vol.9 , pp. 44-49
    • Keating, M.J.1    Kantarjian, H.2    O'Brien, S.3
  • 20
    • 0027323550 scopus 로고
    • Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment
    • O'Brien S., Kantarjian H., Beran M., et al. Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Blood. 82 (1993) 1695-1700
    • (1993) Blood. , vol.82 , pp. 1695-1700
    • O'Brien, S.1    Kantarjian, H.2    Beran, M.3
  • 21
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL
    • Johnson S., Smith A.G., Loffler H., et al. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL. Lancet. 347 (1996) 1432-1438
    • (1996) Lancet. , vol.347 , pp. 1432-1438
    • Johnson, S.1    Smith, A.G.2    Loffler, H.3
  • 22
    • 33845970214 scopus 로고    scopus 로고
    • Comparison of the efficacy and toxicity of fludarabine (F) in first line therapy of younger versus elderly patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a meta-analysis of two phase III trials of the German CLL Study Group (GCLLSG) [abstract]
    • abstract 717
    • Eichhorst B.F., Busch R., Wendtner C.M., and Hallek M. Comparison of the efficacy and toxicity of fludarabine (F) in first line therapy of younger versus elderly patients (pts) with advanced chronic lymphocytic leukemia (CLL): results of a meta-analysis of two phase III trials of the German CLL Study Group (GCLLSG) [abstract]. Blood. 106 (2005) abstract 717
    • (2005) Blood. , vol.106
    • Eichhorst, B.F.1    Busch, R.2    Wendtner, C.M.3    Hallek, M.4
  • 23
    • 26944435896 scopus 로고    scopus 로고
    • Comparison of cladribine plus prednisone with chlorambucil plus prednisone in patients with chronic lymphocytic leukemia. Final report of the Polish Adult Leukemia Group (PALG CLL1)
    • Robak T., Blonski J.Z., Kasznicki M., et al. Comparison of cladribine plus prednisone with chlorambucil plus prednisone in patients with chronic lymphocytic leukemia. Final report of the Polish Adult Leukemia Group (PALG CLL1). Med Sci Monit. 11 (2005) PI71-PI79
    • (2005) Med Sci Monit. , vol.11
    • Robak, T.1    Blonski, J.Z.2    Kasznicki, M.3
  • 24
    • 0028945716 scopus 로고
    • 2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia
    • Saven A., Lemon R.H., Kosty M., Beutler E., and Piro L.D. 2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia. J Clin Oncol. 13 (1995) 570-574
    • (1995) J Clin Oncol. , vol.13 , pp. 570-574
    • Saven, A.1    Lemon, R.H.2    Kosty, M.3    Beutler, E.4    Piro, L.D.5
  • 25
    • 33749586617 scopus 로고    scopus 로고
    • Cladribine (CdA) or fludarabine (F) or high-dose intermittent chlorambucil (Chl) as first-line treatment of symptomatic chronic lymphocytic leukemia? First interim analysis of data from the international randomized phase III trial [abstract]
    • abstract 3470
    • Karisson K., Stromberg M., Jonsson V., et al. Cladribine (CdA) or fludarabine (F) or high-dose intermittent chlorambucil (Chl) as first-line treatment of symptomatic chronic lymphocytic leukemia? First interim analysis of data from the international randomized phase III trial [abstract]. Blood. 104 (2004) abstract 3470
    • (2004) Blood. , vol.104
    • Karisson, K.1    Stromberg, M.2    Jonsson, V.3
  • 26
    • 0024551346 scopus 로고
    • Pentostatin in chronic lymphocytic leukemia: a phase II trial of Cancer and Leukemia group B
    • Dillman R.O., Mick R., and McIntyre O.R. Pentostatin in chronic lymphocytic leukemia: a phase II trial of Cancer and Leukemia group B. J Clin Oncol. 7 (1989) 433-438
    • (1989) J Clin Oncol. , vol.7 , pp. 433-438
    • Dillman, R.O.1    Mick, R.2    McIntyre, O.R.3
  • 27
    • 0035880884 scopus 로고    scopus 로고
    • Impact of therapy with chlorambucil, fludarabine, or fludarabine plus chlorambucil on infections in patients with chronic lymphocytic leukemia: Intergroup Study Cancer and Leukemia Group B 9011
    • Morrison V.A., Rai K.R., Peterson B.L., et al. Impact of therapy with chlorambucil, fludarabine, or fludarabine plus chlorambucil on infections in patients with chronic lymphocytic leukemia: Intergroup Study Cancer and Leukemia Group B 9011. J Clin Oncol. 19 (2001) 3611-3621
    • (2001) J Clin Oncol. , vol.19 , pp. 3611-3621
    • Morrison, V.A.1    Rai, K.R.2    Peterson, B.L.3
  • 28
    • 0032529509 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy
    • Keating M.J., O'Brien S., Lerner S., et al. Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy. Blood. 92 (1998) 1165-1171
    • (1998) Blood. , vol.92 , pp. 1165-1171
    • Keating, M.J.1    O'Brien, S.2    Lerner, S.3
  • 29
    • 0034235909 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies
    • Flinn I.W., Byrd J.C., Morrison C., et al. Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies. Blood. 96 (2000) 71-75
    • (2000) Blood. , vol.96 , pp. 71-75
    • Flinn, I.W.1    Byrd, J.C.2    Morrison, C.3
  • 30
    • 7844239444 scopus 로고    scopus 로고
    • Factors associated with successful mobilization of peripheral blood progenitor cells in 200 patients with lymphoid malignancies
    • Ketterer N., Salles G., Moullet I., et al. Factors associated with successful mobilization of peripheral blood progenitor cells in 200 patients with lymphoid malignancies. Br J Haematol. 103 (1998) 235-242
    • (1998) Br J Haematol. , vol.103 , pp. 235-242
    • Ketterer, N.1    Salles, G.2    Moullet, I.3
  • 31
    • 0034585610 scopus 로고    scopus 로고
    • Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma
    • Micallef I.N., Apostolidis J., Rohatiner A.Z., et al. Factors which predict unsuccessful mobilisation of peripheral blood progenitor cells following G-CSF alone in patients with non-Hodgkin's lymphoma. Hematol J. 1 (2000) 367-373
    • (2000) Hematol J. , vol.1 , pp. 367-373
    • Micallef, I.N.1    Apostolidis, J.2    Rohatiner, A.Z.3
  • 32
    • 9144222685 scopus 로고    scopus 로고
    • Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia
    • Tournilhac O., Cazin B., Lepretre S., et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 103 (2004) 363-365
    • (2004) Blood. , vol.103 , pp. 363-365
    • Tournilhac, O.1    Cazin, B.2    Lepretre, S.3
  • 33
    • 10744225244 scopus 로고    scopus 로고
    • Successful CD34+ cell mobilization by intermediate-dose Ara-C in chronic lymphocytic leukemia patients treated with sequential fludarabine and Campath-1H
    • Montillo M., Tedeschi A., Rossi V., et al. Successful CD34+ cell mobilization by intermediate-dose Ara-C in chronic lymphocytic leukemia patients treated with sequential fludarabine and Campath-1H. Leukemia. 18 (2004) 57-62
    • (2004) Leukemia. , vol.18 , pp. 57-62
    • Montillo, M.1    Tedeschi, A.2    Rossi, V.3
  • 34
    • 20944432005 scopus 로고    scopus 로고
    • Mobilization of peripheral blood stem cells in CLL patients after front-line fludarabine treatment
    • Lysak D., Koza V., Steinerova K., Jindra P., Vozobulova V., and Schutzova M. Mobilization of peripheral blood stem cells in CLL patients after front-line fludarabine treatment. Ann Hematol. 84 (2005) 456-461
    • (2005) Ann Hematol. , vol.84 , pp. 456-461
    • Lysak, D.1    Koza, V.2    Steinerova, K.3    Jindra, P.4    Vozobulova, V.5    Schutzova, M.6
  • 35
    • 0031724663 scopus 로고    scopus 로고
    • Fludarabine-related hemolytic anemia in chronic lymphocytic leukemia and lymphoproliferative disorders
    • Taha H.M., Narasihman P., Venkatesh L., Cawley M., and Kaplan B. Fludarabine-related hemolytic anemia in chronic lymphocytic leukemia and lymphoproliferative disorders. Am J Hematol. 59 (1998) 316
    • (1998) Am J Hematol. , vol.59 , pp. 316
    • Taha, H.M.1    Narasihman, P.2    Venkatesh, L.3    Cawley, M.4    Kaplan, B.5
  • 36
    • 0028853728 scopus 로고
    • Fludarabine-related autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia
    • Myint H., Copplestone J.A., Orchard J., et al. Fludarabine-related autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia. Br J Haematol. 91 (1995) 341-344
    • (1995) Br J Haematol. , vol.91 , pp. 341-344
    • Myint, H.1    Copplestone, J.A.2    Orchard, J.3
  • 37
    • 0027436016 scopus 로고
    • Fludarabine: pharmacokinetics, mechanisms of action, and rationales for combination therapies
    • Plunkett W., Gandhi V., Huang P., et al. Fludarabine: pharmacokinetics, mechanisms of action, and rationales for combination therapies. Semin Oncol. 20 (1993) 2-12
    • (1993) Semin Oncol. , vol.20 , pp. 2-12
    • Plunkett, W.1    Gandhi, V.2    Huang, P.3
  • 39
    • 0035282055 scopus 로고    scopus 로고
    • Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
    • O'Brien S.M., Kantarjian H.M., Cortes J., et al. Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia. J Clin Oncol. 19 (2001) 1414-1420
    • (2001) J Clin Oncol. , vol.19 , pp. 1414-1420
    • O'Brien, S.M.1    Kantarjian, H.M.2    Cortes, J.3
  • 40
    • 0033993573 scopus 로고    scopus 로고
    • Phase I study of fludarabine plus cyclophosphamide in patients with previously untreated low-grade lymphoma: results and and long-term follow-up-a report from the Eastern Cooperative Oncology Group
    • Hochster H.S., Oken M.M., Winter J.N., et al. Phase I study of fludarabine plus cyclophosphamide in patients with previously untreated low-grade lymphoma: results and and long-term follow-up-a report from the Eastern Cooperative Oncology Group. J Clin Oncol. 18 (2000) 987-994
    • (2000) J Clin Oncol. , vol.18 , pp. 987-994
    • Hochster, H.S.1    Oken, M.M.2    Winter, J.N.3
  • 41
    • 0037783863 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide for the treatment of advanced chronic lymphocytic leukemia
    • Schiavone E.M., De Simone M., Palmieri S., et al. Fludarabine plus cyclophosphamide for the treatment of advanced chronic lymphocytic leukemia. Eur J Haematol. 71 (2003) 23-28
    • (2003) Eur J Haematol. , vol.71 , pp. 23-28
    • Schiavone, E.M.1    De Simone, M.2    Palmieri, S.3
  • 42
    • 31544434508 scopus 로고    scopus 로고
    • Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia
    • Eichhorst B.F., Busch R., Hopfinger G., et al. Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia. Blood. 107 (2006) 885-891
    • (2006) Blood. , vol.107 , pp. 885-891
    • Eichhorst, B.F.1    Busch, R.2    Hopfinger, G.3
  • 43
    • 26044450179 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide produces a higher complete response rate and more durable remissions than fludarabine in patients with previously untreated CLL: Intergroup Trial E2997 [abstract]
    • abstract 475
    • Flinn I.W., Kumm E., Grever M.R., et al. Fludarabine and cyclophosphamide produces a higher complete response rate and more durable remissions than fludarabine in patients with previously untreated CLL: Intergroup Trial E2997 [abstract]. Blood. 104 (2004) abstract 475
    • (2004) Blood. , vol.104
    • Flinn, I.W.1    Kumm, E.2    Grever, M.R.3
  • 44
    • 0037106257 scopus 로고    scopus 로고
    • Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011
    • Morrison V.A., Rai K.R., Peterson B.L., et al. Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. J Clin Oncol. 20 (2002) 3878-3884
    • (2002) J Clin Oncol. , vol.20 , pp. 3878-3884
    • Morrison, V.A.1    Rai, K.R.2    Peterson, B.L.3
  • 45
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd J.C., Murphy T., Howard R.S., et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol. 19 (2001) 2153-2164
    • (2001) J Clin Oncol. , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 46
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd J.C., Peterson B.L., Morrison V.A., et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood. 101 (2003) 6-14
    • (2003) Blood. , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3
  • 47
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program
    • McLaughlin P., Grillo-Lopez A.J., Link B.K., et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 16 (1998) 2825-2833
    • (1998) J Clin Oncol. , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3
  • 48
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients
    • Nguyen D.T., Amess J.A., Doughty H., Hendry L., and Diamond L.W. IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur J Haematol. 62 (1999) 76-82
    • (1999) Eur J Haematol. , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3    Hendry, L.4    Diamond, L.W.5
  • 49
    • 0033968522 scopus 로고    scopus 로고
    • European phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma
    • Foran J.M., Rohatiner A.Z., Cunningham D., et al. European phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma. J Clin Oncol. 18 (2000) 317-324
    • (2000) J Clin Oncol. , vol.18 , pp. 317-324
    • Foran, J.M.1    Rohatiner, A.Z.2    Cunningham, D.3
  • 50
    • 7844225540 scopus 로고    scopus 로고
    • Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma
    • Berinstein N.L., Grillo-Lopez A.J., White C.A., et al. Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol. 9 (1998) 995-1001
    • (1998) Ann Oncol. , vol.9 , pp. 995-1001
    • Berinstein, N.L.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 51
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)
    • Winkler U., Jensen M., Manzke O., Schulz H., Diehl V., and Engert A. Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood. 94 (1999) 2217-2224
    • (1999) Blood. , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3    Schulz, H.4    Diehl, V.5    Engert, A.6
  • 52
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth J.D., Litchy S., Barton J.H., et al. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol. 21 (2003) 1746-1751
    • (2003) J Clin Oncol. , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3
  • 53
    • 0037108822 scopus 로고    scopus 로고
    • Rituximab as first-line and maintenance therapy for patients with indolent non-hodgkin's lymphoma
    • Hainsworth J.D., Litchy S., Burris III H.A., et al. Rituximab as first-line and maintenance therapy for patients with indolent non-hodgkin's lymphoma. J Clin Oncol. 20 (2002) 4261-4267
    • (2002) J Clin Oncol. , vol.20 , pp. 4261-4267
    • Hainsworth, J.D.1    Litchy, S.2    Burris III, H.A.3
  • 54
    • 79951658129 scopus 로고    scopus 로고
    • Single-agent Rituxan in early stage chronic lymphocytic leukemia (CLL) [abstract]
    • abstract 1533
    • Thomas D.A., O'Brien S., Giles F.J., et al. Single-agent Rituxan in early stage chronic lymphocytic leukemia (CLL) [abstract]. Blood. 98 (2001) abstract 1533
    • (2001) Blood. , vol.98
    • Thomas, D.A.1    O'Brien, S.2    Giles, F.J.3
  • 55
    • 23044510136 scopus 로고    scopus 로고
    • Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia
    • Keating M.J., O'Brien S., Albitar M., et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia. J Clin Oncol. 23 (2005) 4079-4088
    • (2005) J Clin Oncol. , vol.23 , pp. 4079-4088
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 56
    • 33644847307 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy
    • Byrd J.C., Gribben J.G., Peterson B.L., et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy. J Clin Oncol. 24 (2006) 437-443
    • (2006) J Clin Oncol. , vol.24 , pp. 437-443
    • Byrd, J.C.1    Gribben, J.G.2    Peterson, B.L.3
  • 57
    • 29144449249 scopus 로고    scopus 로고
    • The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia
    • Del Poeta G., Del Principe M.I., Consalvo M.A., et al. The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia. Cancer. 104 (2005) 2743-2752
    • (2005) Cancer. , vol.104 , pp. 2743-2752
    • Del Poeta, G.1    Del Principe, M.I.2    Consalvo, M.A.3
  • 58
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • Byrd J.C., Rai K., Peterson B.L., et al. Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011. Blood. 105 (2005) 49-53
    • (2005) Blood. , vol.105 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3
  • 59
    • 31544480521 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide achieves high complete response rate in patients with previously untreated chronic lymphocytic leukemia: E1997 [abstract]
    • abstract 2649
    • Flinn I.W., Jemiai Y., and Bennett J.M. Fludarabine and cyclophosphamide achieves high complete response rate in patients with previously untreated chronic lymphocytic leukemia: E1997 [abstract]. Blood. 98 (2001) abstract 2649
    • (2001) Blood. , vol.98
    • Flinn, I.W.1    Jemiai, Y.2    Bennett, J.M.3
  • 60
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A., Fassas A.S., Anagnostopoulos A., Dyer M.J., Catovsky D., and Mellstedt H. Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol. 93 (1996) 151-153
    • (1996) Br J Haematol. , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.S.2    Anagnostopoulos, A.3    Dyer, M.J.4    Catovsky, D.5    Mellstedt, H.6
  • 61
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J., Kimby E., Bjorkholm M., et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood. 100 (2002) 768-773
    • (2002) Blood. , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 62
    • 1542503801 scopus 로고    scopus 로고
    • Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
    • Lundin J., Porwit-MacDonald A., Rossmann E.D., et al. Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia. 18 (2004) 484-490
    • (2004) Leukemia. , vol.18 , pp. 484-490
    • Lundin, J.1    Porwit-MacDonald, A.2    Rossmann, E.D.3
  • 63
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien S.M., Kantarjian H.M., Thomas D.A., et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer. 98 (2003) 2657-2663
    • (2003) Cancer. , vol.98 , pp. 2657-2663
    • O'Brien, S.M.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 64
    • 14244262359 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL): CALGB study 19901 [abstract]
    • abstract 2506
    • Rai K.R., Byrd J.C., Peterson B., Gautier M., and Larson R.A. Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL): CALGB study 19901 [abstract]. Blood. 102 (2003) abstract 2506
    • (2003) Blood. , vol.102
    • Rai, K.R.1    Byrd, J.C.2    Peterson, B.3    Gautier, M.4    Larson, R.A.5
  • 65
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • Wendtner C.M., Ritgen M., Schweighofer C.D., et al. Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia. 18 (2004) 1093-1101
    • (2004) Leukemia. , vol.18 , pp. 1093-1101
    • Wendtner, C.M.1    Ritgen, M.2    Schweighofer, C.D.3
  • 66
    • 33744793781 scopus 로고    scopus 로고
    • Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia
    • Montillo M., Tedeschi A., Miqueleiz S., et al. Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia. J Clin Oncol. 24 (2006) 2337-2342
    • (2006) J Clin Oncol. , vol.24 , pp. 2337-2342
    • Montillo, M.1    Tedeschi, A.2    Miqueleiz, S.3
  • 67
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • el Rouby S., Thomas A., Costin D., et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood. 82 (1993) 3452-3459
    • (1993) Blood. , vol.82 , pp. 3452-3459
    • el Rouby, S.1    Thomas, A.2    Costin, D.3
  • 68
    • 0037228952 scopus 로고    scopus 로고
    • Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab
    • Byrd J.C., Smith L., Hackbarth M.L., et al. Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab. Cancer Res. 63 (2003) 36-38
    • (2003) Cancer Res. , vol.63 , pp. 36-38
    • Byrd, J.C.1    Smith, L.2    Hackbarth, M.L.3
  • 69
    • 0030248425 scopus 로고    scopus 로고
    • Trisomy 12 and p53 deletion in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: association with morphology and resistance to conventional chemotherapy
    • Cano I., Martinez J., Quevedo E., et al. Trisomy 12 and p53 deletion in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: association with morphology and resistance to conventional chemotherapy. Cancer Genet Cytogenet. 90 (1996) 118-124
    • (1996) Cancer Genet Cytogenet. , vol.90 , pp. 118-124
    • Cano, I.1    Martinez, J.2    Quevedo, E.3
  • 70
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G., Heerema N.A., Flinn I.W., et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 103 (2004) 3278-3281
    • (2004) Blood. , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 71
    • 4344628597 scopus 로고    scopus 로고
    • VH mutation status and genomic aberrations in the prospective CLL1 Trial (Binet-A) of the German CLL Study Group (GCLLSG) [abstract]
    • abstract 628
    • Stilgenbauer S., Krober A., Winkler D., et al. VH mutation status and genomic aberrations in the prospective CLL1 Trial (Binet-A) of the German CLL Study Group (GCLLSG) [abstract]. Blood. 100 (2002) abstract 628
    • (2002) Blood. , vol.100
    • Stilgenbauer, S.1    Krober, A.2    Winkler, D.3
  • 72
    • 33846003608 scopus 로고    scopus 로고
    • Outcome of treatment with fludarabine versus fludarabine and cyclophosphamide in chronic lymphocytic leukemia (CLL) is adversely impacted by high risk genetic features: results from ECOG 2997 [abstract]
    • abstract 3487
    • Grever M.R., Lucas D.M., Dewald G.W., et al. Outcome of treatment with fludarabine versus fludarabine and cyclophosphamide in chronic lymphocytic leukemia (CLL) is adversely impacted by high risk genetic features: results from ECOG 2997 [abstract]. Blood. 104 (2004) abstract 3487
    • (2004) Blood. , vol.104
    • Grever, M.R.1    Lucas, D.M.2    Dewald, G.W.3
  • 73
    • 27144522767 scopus 로고    scopus 로고
    • Response to therapy and survival in CLL is influenced by genetic markers. Preliminary analysis from the LRF CLL4 trial [abstract]
    • Catovsky D., Richards S., Matutes E., et al. Response to therapy and survival in CLL is influenced by genetic markers. Preliminary analysis from the LRF CLL4 trial [abstract]. Blood. (2004) 104
    • (2004) Blood. , pp. 104
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 74
    • 24344483414 scopus 로고    scopus 로고
    • Combination chemotherapy with pentostatin, cyclophosphamide, and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia [abstract]
    • abstract 339
    • Kay N.E., Greyer S.M., Lin T., et al. Combination chemotherapy with pentostatin, cyclophosphamide, and rituximab induces high rate of remissions including complete responses and achievement of minimal residual disease in previously untreated B-chronic lymphocytic leukemia [abstract]. Blood. 104 (2004) abstract 339
    • (2004) Blood. , vol.104
    • Kay, N.E.1    Greyer, S.M.2    Lin, T.3
  • 75
    • 33746839511 scopus 로고    scopus 로고
    • 17p deletion predicts for inferior overall survival after fludarabine-based first line therapy in chronic lymphocytic leukemia: first analysis of genetics in the CLL4 Trial of the GCLLSG [abstract]
    • abstract 715
    • Stilgenbauer S., Krober A., Busch R., et al. 17p deletion predicts for inferior overall survival after fludarabine-based first line therapy in chronic lymphocytic leukemia: first analysis of genetics in the CLL4 Trial of the GCLLSG [abstract]. Blood. 106 (2005) abstract 715
    • (2005) Blood. , vol.106
    • Stilgenbauer, S.1    Krober, A.2    Busch, R.3
  • 76
    • 28844483804 scopus 로고    scopus 로고
    • Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia
    • Gribben J.G., Zahrieh D., Stephans K., et al. Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia. Blood. 106 (2005) 4389-4396
    • (2005) Blood. , vol.106 , pp. 4389-4396
    • Gribben, J.G.1    Zahrieh, D.2    Stephans, K.3
  • 77
    • 20544465644 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia
    • Sorror M.L., Maris M.B., Sandmaier B.M., et al. Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia. J Clin Oncol. 23 (2005) 3819-3829
    • (2005) J Clin Oncol. , vol.23 , pp. 3819-3829
    • Sorror, M.L.1    Maris, M.B.2    Sandmaier, B.M.3
  • 78
    • 13344287042 scopus 로고    scopus 로고
    • HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry
    • Michallet M., Archimbaud E., Bandini G., et al. HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. European Group for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry. Ann Intern Med. 124 (1996) 311-315
    • (1996) Ann Intern Med. , vol.124 , pp. 311-315
    • Michallet, M.1    Archimbaud, E.2    Bandini, G.3
  • 79
    • 20844436596 scopus 로고    scopus 로고
    • Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis
    • Dreger P., Brand R., Milligan D., et al. Reduced-intensity conditioning lowers treatment-related mortality of allogeneic stem cell transplantation for chronic lymphocytic leukemia: a population-matched analysis. Leukemia. 19 (2005) 1029-1033
    • (2005) Leukemia. , vol.19 , pp. 1029-1033
    • Dreger, P.1    Brand, R.2    Milligan, D.3
  • 80
    • 2642551675 scopus 로고    scopus 로고
    • Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR
    • Ritgen M., Stilgenbauer S., von Neuhoff N., et al. Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR. Blood. 104 (2004) 2600-2602
    • (2004) Blood. , vol.104 , pp. 2600-2602
    • Ritgen, M.1    Stilgenbauer, S.2    von Neuhoff, N.3
  • 81
    • 0037370910 scopus 로고    scopus 로고
    • Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia
    • Ritgen M., Lange A., Stilgenbauer S., et al. Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia. Blood. 101 (2003) 2049-2053
    • (2003) Blood. , vol.101 , pp. 2049-2053
    • Ritgen, M.1    Lange, A.2    Stilgenbauer, S.3
  • 82
    • 1642292996 scopus 로고    scopus 로고
    • The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status
    • Dreger P., Stilgenbauer S., Benner A., et al. The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status. Blood. 103 (2004) 2850-2858
    • (2004) Blood. , vol.103 , pp. 2850-2858
    • Dreger, P.1    Stilgenbauer, S.2    Benner, A.3
  • 83
    • 0035204544 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation in patients with sensitive low-grade lymphoma or mantle cell lymphoma
    • Berdeja J.G., Jones R.J., Zahurak M.L., et al. Allogeneic bone marrow transplantation in patients with sensitive low-grade lymphoma or mantle cell lymphoma. Biol Blood Marrow Transplant. 7 (2001) 561-567
    • (2001) Biol Blood Marrow Transplant. , vol.7 , pp. 561-567
    • Berdeja, J.G.1    Jones, R.J.2    Zahurak, M.L.3
  • 84
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • Schulz H., Klein S.K., Rehwald U., et al. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood. 100 (2002) 3115-3120
    • (2002) Blood. , vol.100 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.