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Volumn 1171, Issue , 2009, Pages 242-249

Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells?

Author keywords

Apoptosis; CDKs; Cell cycle arrest; G1 arrest; p53 tumor suppressor; Pharmacological CDK inhibitors

Indexed keywords

DNA; OLOMOUCINE;

EID: 69149092103     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04700.x     Document Type: Conference Paper
Times cited : (4)

References (31)
  • 1
    • 0036901957 scopus 로고    scopus 로고
    • Cyclin-dependent kinases and cell cycle control (Nobel lecture)
    • Nurse, P. 2002. Cyclin-dependent kinases and cell cycle control (Nobel lecture). Chembiochem 3 : 596 603.
    • (2002) Chembiochem , vol.3 , pp. 596-603
    • Nurse, P.1
  • 2
    • 0242708738 scopus 로고    scopus 로고
    • Small-molecule cyclin-dependent kinase modulators
    • Senderowicz, A.M. 2003. Small-molecule cyclin-dependent kinase modulators. Oncogene 22 : 6609 6620.
    • (2003) Oncogene , vol.22 , pp. 6609-6620
    • Senderowicz, A.M.1
  • 3
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C.J. J.M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13 : 1501 1512.
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 4
    • 0029797695 scopus 로고    scopus 로고
    • The molecular basis of carcinogenesis: Understanding the cell cycle clock
    • Weinberg, R.A. 1996. The molecular basis of carcinogenesis: understanding the cell cycle clock. Cytokines Mol. Ther. 2 : 105 110.
    • (1996) Cytokines Mol. Ther. , vol.2 , pp. 105-110
    • Weinberg, R.A.1
  • 5
    • 0037051095 scopus 로고    scopus 로고
    • P53: An ubiquitous target of anticancer drugs
    • Blagosklonny, M.V. 2002. p53: an ubiquitous target of anticancer drugs. Int. J. Cancer 98 : 161 166.
    • (2002) Int. J. Cancer , vol.98 , pp. 161-166
    • Blagosklonny, M.V.1
  • 6
    • 34547806596 scopus 로고    scopus 로고
    • Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence
    • Schmid, G., M. Maurer, M.P. Kramer, et al. 2007. Cellular and organismal ageing: role of the p53 tumor suppressor protein in the induction of transient and terminal senescence. J. Cell. Biochem. 101 : 1355 1369.
    • (2007) J. Cell. Biochem. , vol.101 , pp. 1355-1369
    • Schmid, G.1    Maurer, M.2    Kramer, M.P.3
  • 8
    • 0036145018 scopus 로고    scopus 로고
    • Multiple roles of the tumor suppressor p53
    • Bargonetti, J. J.J. Manfredi. 2002. Multiple roles of the tumor suppressor p53. Curr. Opin. Oncol. 14 : 86 91.
    • (2002) Curr. Opin. Oncol. , vol.14 , pp. 86-91
    • Bargonetti, J.1    Manfredi, J.J.2
  • 9
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry, W.S., T. Tokino, V.E. Velculescu, et al. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75 : 817 825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 10
    • 0019981970 scopus 로고
    • Oncogene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient
    • Dalla-Favera, R., et al. 1982. Oncogene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient. Nature 299 : 61 63.
    • (1982) Nature , vol.299 , pp. 61-63
    • Dalla-Favera, R.1
  • 11
    • 0001606206 scopus 로고
    • Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cell
    • Wolf, D. V. Rotter. 1985. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cell. Proc. Natl. Acad. Sci. USA 82 : 790 794.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 790-794
    • Wolf, D.1    Rotter, V.2
  • 12
    • 0028785913 scopus 로고
    • Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress
    • Banerjee, D., H.J. Lenz, et al. 1995. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Differ. 6 : 1405 1413.
    • (1995) Cell Growth Differ. , vol.6 , pp. 1405-1413
    • Banerjee, D.1    Lenz, H.J.2
  • 13
    • 2942707103 scopus 로고
    • Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas
    • Durst, M., C.M. Croce, L. Gissmann, et al. 1987. Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc. Natl. Acad. Sci. USA 84 : 1070 1074.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1070-1074
    • Durst, M.1    Croce, C.M.2    Gissmann, L.3
  • 14
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., B.A. Werness, J.M. Huibregtse, et al. 1990 : The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63 : 1129 1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3
  • 15
    • 0028177401 scopus 로고
    • P53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
    • Slebos, R.J., M.H. Lee, B.S. Plunkett, et al. 1994. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA 91 : 5320 5324.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5320-5324
    • Slebos, R.J.1    Lee, M.H.2    Plunkett, B.S.3
  • 16
    • 0034702266 scopus 로고    scopus 로고
    • Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines
    • Edamatsu, H., C.L. Gau, T. Nemoto, et al. 2000. Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines. Oncogene 19 : 3059 3068.
    • (2000) Oncogene , vol.19 , pp. 3059-3068
    • Edamatsu, H.1    Gau, C.L.2    Nemoto, T.3
  • 17
    • 0041622837 scopus 로고    scopus 로고
    • Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells
    • Wojciechowski, J., M. Horky, M. Gueorguieva J. Wesierska-Gadek. 2003. Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells. Int. J. Cancer 106 : 486 495.
    • (2003) Int. J. Cancer , vol.106 , pp. 486-495
    • Wojciechowski, J.1    Horky, M.2    Gueorguieva, M.3    Wesierska-Gadek, J.4
  • 18
    • 0346327392 scopus 로고    scopus 로고
    • Dual action of cyclin-dependent kinase inhibitors: Induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin
    • Wesierska-Gadek, J., M. Gueorguieva M. Horky. 2003. Dual action of cyclin-dependent kinase inhibitors: induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin. Pol. J. Pharmacol. 55 : 895 902.
    • (2003) Pol. J. Pharmacol. , vol.55 , pp. 895-902
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Horky, M.3
  • 19
    • 29844452101 scopus 로고    scopus 로고
    • Dual action of the inhibitors of cyclin-dependent kinases: Targeting of the cell-cycle progression and activation of wild-type p53 protein
    • Wesierska-Gadek, J. G. Schmid. 2006. Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein. Expert Opin. Investig. Drugs 15 : 23 38.
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 23-38
    • Wesierska-Gadek, J.1    Schmid, G.2
  • 20
    • 0031028163 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinases by purine analogues: Crystal structure of human cdk2 complexed with roscovitine
    • De Azevedo, W.F., S. Leclerc, L. Meijer, et al. 1997. Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur. J. Biochem. 243 : 518 526.
    • (1997) Eur. J. Biochem. , vol.243 , pp. 518-526
    • De Azevedo, W.F.1    Leclerc, S.2    Meijer, L.3
  • 21
    • 0344809977 scopus 로고    scopus 로고
    • ATP-site directed inhibitors of cyclin-dependent kinases
    • Gray, N., L. Détivaud, C. Doerig L. Meijer. 1999. ATP-site directed inhibitors of cyclin-dependent kinases. Curr. Med. Chem. 6 : 859 875.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 859-875
    • Gray, N.1    Détivaud, L.2    Doerig, C.3    Meijer, L.4
  • 22
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
    • Meijer, L., A. Borgne, O. Mulner, et al. 1997. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243 : 527 536.
    • (1997) Eur. J. Biochem. , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3
  • 23
    • 36849095991 scopus 로고    scopus 로고
    • A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: Up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein
    • Wesierska-Gadek, J., M. Gueorguieva, M.P. Kramer, et al. 2007. A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein. J. Cell Biochem. 102 : 1405 1419.
    • (2007) J. Cell Biochem. , vol.102 , pp. 1405-1419
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Kramer, M.P.3
  • 24
    • 3042741064 scopus 로고    scopus 로고
    • Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest
    • Wesierska-Gadek, J., D. Schloffer, M. Gueorguieva, et al. 2004. Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest. Cancer Res. 64 : 4487 4497.
    • (2004) Cancer Res. , vol.64 , pp. 4487-4497
    • Wesierska-Gadek, J.1    Schloffer, D.2    Gueorguieva, M.3
  • 25
    • 0033759112 scopus 로고    scopus 로고
    • Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint
    • Wesierska-Gadek, J. G. Schmid. 2000. Overexpressed poly(ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint. J. Cell. Biochem. 80 : 85 103.
    • (2000) J. Cell. Biochem. , vol.80 , pp. 85-103
    • Wesierska-Gadek, J.1    Schmid, G.2
  • 26
    • 0020530724 scopus 로고
    • A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
    • Vindeløv, L.L., I.J. Christensen N.I. Nissen. 1983. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3 : 323 327.
    • (1983) Cytometry , vol.3 , pp. 323-327
    • Vindeløv, L.L.1    Christensen, I.J.2    Nissen, N.I.3
  • 27
    • 0037056222 scopus 로고    scopus 로고
    • Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy
    • Wesierska-Gadek, J., D. Schloffer, V. Kotala M. Horky. 2002. Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy. Int. J. Cancer 101 : 128 136.
    • (2002) Int. J. Cancer , vol.101 , pp. 128-136
    • Wesierska-Gadek, J.1    Schloffer, D.2    Kotala, V.3    Horky, M.4
  • 28
    • 41749096110 scopus 로고    scopus 로고
    • Signaling of DNA damage is not sufficient to induce p53 response: (Re)activation of wt p53 protein strongly depends on cellular context
    • Wesierska-Gadek, J., M. Gueorguieva, O. Komina, et al. 2008. Signaling of DNA damage is not sufficient to induce p53 response: (re)activation of wt p53 protein strongly depends on cellular context. J. Cell Biochem. 103 : 1607 1620.
    • (2008) J. Cell Biochem. , vol.103 , pp. 1607-1620
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Komina, O.3
  • 29
    • 26444553679 scopus 로고    scopus 로고
    • A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death
    • Wesierska-Gadek, J., M. Gueorguieva, C. Ranftler G. Zerza-Schnitzhofer. 2005. A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death. J. Cell Biochem. 96 : 1 7.
    • (2005) J. Cell Biochem. , vol.96 , pp. 1-7
    • Wesierska-Gadek, J.1    Gueorguieva, M.2    Ranftler, C.3    Zerza-Schnitzhofer, G.4
  • 30
    • 0031586330 scopus 로고    scopus 로고
    • Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c
    • Wang, X. G.P. Studzinski. 1997. Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c. Exp. Cell Res. 235 : 210 217.
    • (1997) Exp. Cell Res. , vol.235 , pp. 210-217
    • Wang, X.1    Studzinski, G.P.2
  • 31
    • 0028954227 scopus 로고
    • CDK-activating kinase complex is a component of human transcription factor TFIIH
    • Shiekhattar, R., F. Mermelstein, R.P. Fischer, et al. 1995. CDK-activating kinase complex is a component of human transcription factor TFIIH. Nature 374 : 283 287.
    • (1995) Nature , vol.374 , pp. 283-287
    • Shiekhattar, R.1    Mermelstein, F.2    Fischer, R.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.