Tocotrienol ameliorates behavioral and biochemical alterations in the rat model of alcoholic neuropathy

Pain

Volumn 145, Issue 1-2, 2009, Pages 129-135

  Tiwari, Vinod ^a   Kuhad, Anurag ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Alcoholic neuropathy; Allodynia; Hyperalgesia; Oxidative stress; Tocotrienol; Vitamin E

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; GLUTATHIONE; INTERLEUKIN 1BETA; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOLISM; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DRUG EFFECT; HYPERALGESIA; LIPID PEROXIDATION; MALE; MECHANICAL STRESS; NITROSATIVE STRESS; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SCIATIC NERVE; TEMPERATURE STRESS;

ALCOHOLIC NEUROPATHY; ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; HYPERALGESIA; INTERLEUKIN-1BETA; LIPID PEROXIDATION; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; REACTION TIME; TOCOTRIENOLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69049117166     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2009.05.028     Document Type: Article

References (47)

1. Aley K.O., and Levine J.D. Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat. Neuroscience 111 (2002) 389-397
2. Ali D.W., and Salter M.W. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr Opin Neurobiol 11 (2001) 336-342
3. Burton G.W., and Ingold K.U. Vitamin E as an in vitro and in vivo antioxidant. Ann NY Acad Sci 570 (1989) 7-22
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., and Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53 (1994) 55-63
5. Cooper A.J., and Kristal B.S. Multiple roles of glutathione in the central nervous system. Biol Chem 378 (1997) 793-802
6. Corsetti G., Rezzani R., Rodella L., and Bianchi R. Ultrastructural study of the alterations in spinal ganglion cells of rats chronically fed on ethanol. Ultrastruct Pathol 22 (1998) 309-319
7. Courteix C., Eschalier A., and Lavarenne J. Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 53 (1993) 81-88
8. Dicker E., and Cederbaum A.I. Increased NADH-dependent production of reactive oxygen intermediates by microsomes after chronic ethanol consumption: comparisons with NADPH. Arch Biochem Biophys 293 (1992) 274-280
9. Dina O.A., Barletta J., Chen X., Mutero A., Martin A., Messing R.O., and Levine J.D. Key Role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci 20 (2000) 8614-8619
10. George A., Schmidt C., Weishaupt A., Toyka K.V., and Sommer C. Serial determination of tumor necrosis factor-alpha content in rat sciatic nerve after chronic constriction injury. Exp Neurol 160 (1999) 124-132
11. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
12. Ignatowski T.A., Covey W.C., Knight P.R., Severin C.M., Nickola T.J., and Spengler R.N. Brain-derived TNFα mediates neuropathic pain. Brain Res 841 (1999) 70-77
13. Jollow D.J., Mitchell J.R., Zampaglione N., and Gillette J.R. Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology 11 (1974) 151-169
14. Khanna S., Roy S., Ryu H., Bahadduri P., Swaan P.W., Ratan R.R., and Sen C.K. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278 (2003) 43508-43515
15. Kim H.K., Park S.K., Zhou J.L., Taglialatela G., Chung K., Coggeshall R.E., and Chung J.M. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 111 (2004) 116-124
16. Koike H., Iijima M., Sugiura M., Mori K., Hattori N., Ito H., Hirayama M., and Sobue G. Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54 (2003) 19-29
17. Koike H., Mori K., Misu K., Hattori N., Ito H., Hirayama M., and Sobue G. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology 56 (2001) 1727-1732
18. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186 (1978) 189-195
19. Kuhad A., Bishnoi M., Tiwari V., and Chopra K. Suppression of NF-κβ signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol Biochem Behav 92 (2009) 251-259
20. Lee I., Kim H.K., Kim J.H., Chung K., and Chung J.M. The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 133 (2007) 9-17
21. Levy D., and Zochodne D.W. NO pain: potential roles of nitric oxide in neuropathic pain. Pain Pract 4 (2004) 11-18
22. Lin Q., Wu J., Peng Y.B., Cui M., and Willis W.D. Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons. J Neurophysiol 81 (1999) 1086-1094
23. Mansouri A., Demeilliers C., Amsellem S., Pessayre D., and Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 298 (2001) 737-743
24. Mantle D., and Preedy V.R. Free radicals as mediators of alcohol toxicity. Adverse Drug React Toxicol Rev 18 (1999) 235-252
25. Masamune A., Suzuki N., Kikuta K., Satoh M., Satoh K., and Shimosegawa T. Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem 97 (2006) 1080-1093
26. McDonough K.H. Antioxidant nutrients and alcohol. Toxicology 189 (2003) 89-97
27. Miyoshi K., Narita M., Takatsu M., and Suzuki T. MGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption. Eur J Pharmacol 562 (2007) 208-211
28. Monforte R., Estruch R., Valls-Sole J., Nicolas J., Villalta J., and Urbano-Marquez A. Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol. Arch Neurol 52 (1995) 45-51
29. Naik A.K., Tandan S.K., Dudhgaonkar S.P., Jadhav S.H., Kataria M., Prakash V.R., and Kumar D. Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-l-cysteine in rats. Eur J Pain 10 (2006) 573-579
30. Narita M., Miyoshi K., Narita M., and Suzuki T. Involvement of microglia in the ethanol-induced neuropathic pain-like state in the rat. Neurosci Lett 414 (2007) 21-25
31. Padi S.S., and Kulkarni S.K. Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol 601 (2008) 79-87
32. Pearce B.C., Parker R.A., Deason M.E., Dischino D.D., Gillespie E., Qureshi A.A., Volk K., and Wright J.J. Inhibitors of cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols. J Med Chem 37 (1994) 526-541
33. Raghavendra V., Tanga F., Rutkowski M.D., and DeLeo J.A. Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines. Pain 104 (2003) 655-664
34. Sabrina L.G.V., Van B.L., Aaron Y.L., Kathryn G.T., Klaus B., and Peter A.S. Long-term actions of interleukin-1β on delay and tonic firing neurons in rat superficial dorsal horn and their relevance to central sensitization. Mol Pain 4 (2008) 63
35. Scadding J.W., Wall P.D., Parry C.B., and Brooks D.M. Clinical trial of propranolol in post-traumatic neuralgia. Pain 14 (1982) 283-292
36. Sen C.K., Khanna S., Roy S., and Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 275 (2000) 13049-13055
37. Sen C.K., Khanna S., and Roy S. Tocotrienols: vitamin E beyond tocopherols. Life Sci 78 (2006) 2088-2098
38. Serbinova E., Kagan V., Han D., and Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med 10 (1991) 263-275
39. Serbinova E.A., and Packer L. Antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Methods Enzymol 234 (1994) 354-366
40. Sharma S.S., and Sayyed S.G. Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy. Clin Exp Pharmacol Physiol 33 (2006) 1022-1028
41. Sung C.S., Wen Z.H., Chang W.K., Ho S.T., Tsai S.K., Chang Y.C., and Wong C.S. Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord. Brain Res 1015 (2004) 145-153
42. Suzuki Y.J., Tsuchiya M., Wassall S.R., Choo Y.M., Govil G., Kagan V.E., and Packer L. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32 (1993) 10692-10699
43. Taiwo Y.O., Coderre T.J., and Levine J.D. The contribution of training to sensitivity in the nociceptive paw-withdrawal test. Brain Res 487 (1989) 148-151
44. Wills E.D. Mechanism of lipid peroxide formation in animals. Biochem J 99 (1965) 667-676
45. Wolf G., Gabay E., Tal M., Yirmiya R., and Shavit Y. Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice. Pain 120 (2006) 315-324
46. Wullner U., Seyfried J., Groscurth P., Beinroth S., Winter S., Gleichmann M., Heneka M., Löschmann P., Schulz J.B., Weller M., and Klockgether T. Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Res 826 (1999) 53-62
47. Yerdelen D., Koc F., and Uysal H. Strength-duration properties of sensory and motor axons in alcoholic polyneuropathy. Neurol Res 30 (2008) 746-750