Substitution of the arginine/leucine residues in apidaecin Ib with peptoid residues: Effect on antimicrobial activity, cellular uptake, and proteolytic degradation

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5197-5206

  Gobbo, Marina ^a   Benincasa, Monica ^b   Bertoloni, Giulio ^a   Biondi, Barbara ^c   Dosselli, Ryan ^a   Papini, Emanuele ^a   Reddi, Elena ^a   Rocchi, Raniero ^a   Tavano, Regina ^a   Gennaro, Renato ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APIDAECIN DERIVATIVE; APIDAECIN IB; ARGININE; GLYCINE; HYBRID PROTEIN; LEUCINE; PEPTIDE DERIVATIVE; PEPTOID; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL MEMBRANE TRANSPORT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DEGRADATION; DRUG STABILITY; DRUG SYNTHESIS; DRUG TRANSPORT; DRUG UPTAKE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ARGININE; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; ESCHERICHIA COLI; FLUORESCENT DYES; HELA CELLS; HEMOLYSIS; HUMANS; HYDROLYSIS; KLEBSIELLA PNEUMONIAE; LEUCINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PEPTOIDS; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69049111808     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900396a     Document Type: Article

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