New submonomers for poly N-substituted glycines (peptoids)

Tetrahedron Letters

Volumn 40, Issue 8, 1999, Pages 1475-1478

  Uno, Tetsuo ^a   Beausoleil, Eric ^a   Goldsmith, Richard A ^a   Levine, Barry H ^a   Zuckermann, Ronald N ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 TERT TYRAMINE; 5 AMINO 2,2 DIMETHYL 1,3 DIOXANE; 6 AMINO 6 DEOXYGALACTOPYRANOSE DIACETONIDE; GLYCINE DERIVATIVE; GUANIDINOPROPYLAMINE; TRYPTAMINE DERIVATIVE; TYRAMINE; UNCLASSIFIED DRUG;

ARTICLE; HYDROPHILICITY; MOLECULAR RECOGNITION; ORGANIC CHEMISTRY; PEPTIDE SYNTHESIS; QUANTITATIVE DIAGNOSIS; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0033582767     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02696-3     Document Type: Article

References (10)

1. Zuckermann, R. N.; Martin, E. J.; Spellmeyer, D. C.; Stauber, G. B.; Shoemaker, K. R.; Kerr, J. M.; Figliozzi, G. M.; Goff, D. A.; Siani, M. A.; Simon, R. J.; Banville, S. C.; Brown, E. G.; Wang, L.; Richter, L. S.; Moos, W. H. J. Med Chem. 1994, 37, 2678-2685.
2. a) Murphy, J. E.; Uno, T.; Hamer, J. D.; Cohen, F. E.; Dwarki, V.; Zuckermann, R. N.; Proc. Natl. Acad. Sci. USA 1998, 95, 1517-1522;
3. b) Kirshenbaum, K.; Barron, A. E.; Goldsmith, R. A.; Armand, P.; Bradley, E. K.; Truong, K. T. V.; Dill, K. A.; Cohen, F. E.; Zuckermann, R. N. Proc. Natl. Acad. Sci. USA 1998, 95, 4303;
4. c) Nguyen, J. T.; Turck, C. W.; Cohen, F. E.; Zuckermann, R. N.; Lim, W. A. Science 1998, 282, 2088-2092.
5. Zuckermann, R. N.; Kerr, J.M., Kent, S. B. H.; Moos, W. H. J. Am. Chem. Soc. 1992, 114, 10646-10647.
6. 2O and lyophilized again.
7. Boon, P. J.; Mous, J. F. M.; Ten Kortenaar, P. B. W.; Tesser, G. I. Int. J. Peptide Protein Res. 1986, 28, 477-492.
8. Krstenansky, J., Syntex Corp., personal communication, 1995.
9. Quirk, J. M.; Harsy, S. G.,; Hakansson, C. L. Eur. Patent 0 348 223 A3,1989.
10. 1H NMR δ ppm 5.53 (1H, d), 4.57 (1H, dd), 4.29 (1H, dd), 4.20 (1H, dd), 4.29 ( 1H, m), 3.68 (1H, m), 2.95 ( 1H, dd), 2.82 ( 1H, dd), 1.61 (2H, s), 1.51 (3H, s), 1.42 (3H,s), 1.31 (6H, s).