Dde - A selective primary amine protecting group: A facile solid phase synthetic approach to polyamine conjugates

Tetrahedron Letters

Volumn 37, Issue 15, 1996, Pages 2625-2628

  Nash, Ian A ^a   Bycroft, Barrie W ^a   Chan, Weng C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

POLYAMINE;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; TECHNIQUE;

EID: 0029926329     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00344-9     Document Type: Article

References (20)

1. Mayer, L. M.; Westbrook, G. L. Progr. Neurobiology, 1987, 28, 197-276.
2. Bruce, M.; Bukownik, R.; Eldefrawi, A. T.; Elderfrawi, E. E.; Goodnow Jr, R.; Kallimopoulos, T ; Konno, K.; Nakanishi, K.; Niwa, M.; Usherwood, P. N. R. Toxicon, 1990, 28, 133-1346.
3. Kawai, N.; Excitatory Amino Acid Receptors - Design of Agonists and antagonists; Ellis Horwood: New York: 1992; pp. 292-307, references cited therein.
4. Fedorov, N. B.; Screbitsky, V. G.; Reymann, K. G. European Journal of Pharmacology, 1992, 228, 201-206.
5. Sauer, D.; Fagg, G. E. Excitatory Amino Acid Receptors - Design of Agonists and antagonists; Ellis Horwood: New York: 1992; pp. 20-24, references cited therein.
6. Eldefrawi, A. T.; Elderfrawi, E. E.; Konno, K.; Mansour; N. A.; Nakanishi, K.; Oltz, E.; Usherwood, P. N. R. Proc. Natl. Acad. Sci. USA, 1988, 85, 4910-4913.
7. For example; Choi, S-K.; Goodnow, R. A.; Kalivretenos, A.; Chiles, G. W.; Fushiya, K.; Nakanishi, K. Tetrahedron, 1992, 48, 4793-4822, Choi. S.K.; Nakanishi, K.; Usherwood, P. N. R. Tetrahedron, 1993, 49, 5777-5790 and Blagbrough, I. S.; Brackley, P. T. H.; Bruce, M.; Bycroft, B. W.; Mather, A. J.; Millington, S.; Sudan, H. L.; Usherwood, P. N. R. Toxicon, 1992, 30, 303-322.
8. For example; Choi, S-K.; Goodnow, R. A.; Kalivretenos, A.; Chiles, G. W.; Fushiya, K.; Nakanishi, K. Tetrahedron, 1992, 48, 4793-4822, Choi. S.K.; Nakanishi, K.; Usherwood, P. N. R. Tetrahedron, 1993, 49, 5777-5790 and Blagbrough, I. S.; Brackley, P. T. H.; Bruce, M.; Bycroft, B. W.; Mather, A. J.; Millington, S.; Sudan, H. L.; Usherwood, P. N. R. Toxicon, 1992, 30, 303-322.
9. For example; Choi, S-K.; Goodnow, R. A.; Kalivretenos, A.; Chiles, G. W.; Fushiya, K.; Nakanishi, K. Tetrahedron, 1992, 48, 4793-4822, Choi. S.K.; Nakanishi, K.; Usherwood, P. N. R. Tetrahedron, 1993, 49, 5777-5790 and Blagbrough, I. S.; Brackley, P. T. H.; Bruce, M.; Bycroft, B. W.; Mather, A. J.; Millington, S.; Sudan, H. L.; Usherwood, P. N. R. Toxicon, 1992, 30, 303-322.
10. Bycroft, B. W.; Chan, W. C.; Hone, N. D.; Millington, S.; Nash, I. A. J. Am. Chem. Soc., 1994, 116, 7415-7416.
11. Bycroft, B. W.; Chan. W. C.; Chhabra, S. R.; Hone, N. D. J. Chem. Soc., Chem. Commun. 1993, 778-779.
12. Moya, E.; Blagbrough, I. S. Tetrahedron Lett., 1994, 35, 2061-2062.
13. Barlos, K.; Gatos, D.; Papapholiu, G.; Soltiriu, P.; Wenqing, Y.; Schäfer, W. Tetrahedron Lett., 1989, 30, 3943-3946 and Barlos, K.; Gatos, D.; Papapholiu, G.; Schäfer, W.; Wenqing, Y. Tetrahedron Lett., 1989, 30, 3947-3950.
14. Barlos, K.; Gatos, D.; Papapholiu, G.; Soltiriu, P.; Wenqing, Y.; Schäfer, W. Tetrahedron Lett., 1989, 30, 3943-3946 and Barlos, K.; Gatos, D.; Papapholiu, G.; Schäfer, W.; Wenqing, Y. Tetrahedron Lett., 1989, 30, 3947-3950.
15. Bycroft, B. W.; Chan, W. C.; Nash, I. A. unpublished results.
16. 8,12
17. -1).
18. -1). The elution gradient was 10 to 50%B in 30 minutes. (A = 0.06% aqueous TFA, B = 0.06% TFA in 90% aqueous acetonitrile).
19. 2).
20. + calc. 214.5, found 214.5.