Oligoclonal CD4+ T cells promote host memory immune responses to zwitterionic polysaccharide of Streptococcus pneumoniae

Infection and Immunity

Volumn 77, Issue 9, 2009, Pages 3705-3712

  Groneck, Laura ^a   Schrama, David ^b   Fabri, Mario ^a   Stephen, Tom Li ^a,c   Harms, Fabian ^a   Meemboor, Sonja ^a   Hafke, Helena ^a   Bessler, Martina ^a   Becker, Jürgen C ^b   Kalka Moll, Wiltrud M ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR SP1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOCOCCUS PNEUMONIAE; TH1 CELL; TH17 CELL;

ABSCESS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; POLYSACCHARIDES, BACTERIAL; STREPTOCOCCUS PNEUMONIAE; TH1 CELLS;

EID: 69049111005     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01492-08     Document Type: Article

References (38)

1. Awasthi, A., G. Murugaiyan, and V. K. Kuchroo. 2008. Interplay between effector Th17 and regulatory T cells. J. Clin. Immunol. 28:660-670.
2. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
3. Bettelli, E., M. Oukka, and V. K. Kuchroo. 2007. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8:345-350.
4. Chicz, R. M., R. G. Urban, W. S. Lane, J. C. Gorga, L. J. Stern, D. A. Vignali, and J. L. Strominger. 1992. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature 358:764-768.
5. Choi, Y. H., M. H. Roehrl, D. L. Kasper, and J. Y. Wang. 2002. A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides. Biochemistry 41:15144-15151.
6. Chung, D. R., T. Chitnis, R. J. Panzo, D. L. Kasper, M. H. Sayegh, and A. O. Tzianabos. 2002. CD4+ T cells regulate surgical and postinfectious adhesion formation. J. Exp. Med. 195:1471-1478.
7. Cobb, B. A., and D. L. Kasper. 2008. Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. Glycobiology 18:707-718.
8. Cobb, B. A., Q. Wang, A. O. Tzianabos, and D. L. Kasper. 2004. Polysaccharide processing and presentation by the MHCII pathway. Cell 117:677-687.
9. Dong, C. 2006. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat. Rev. Immunol. 6:329-333.
10. Dutton, R. W., L. M. Bradley, and S. L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201-223.
11. Harrington, L. E., R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy, and C. T. Weaver. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6:1123-1132.
12. Kalka-Moll, W. M., A. O. Tzianabos, P. W. Bryant, M. Niemeyer, H. L. Ploegh, and D. L. Kasper. 2002. Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J. Immunol. 169:6149-6153.
13. Kalka-Moll, W. M., A. O. Tzianabos, Y. Wang, V. J. Carey, R. W. Finberg, A. B. Onderdonk, and D. L. Kasper. 2000. Effect of molecular size on the ability of zwitterionic polysaccharides to stimulate cellular immunity. J. Immunol. 164:719-724.
14. Kalka-Moll, W. M., Y. Wang, L. E. Comstock, S. E. Gonzalez, A. O. Tzianabos, and D. L. Kasper. 2001. Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain. Infect. Immun. 69:2339-2344.
15. Kolls, J. K., and A. Linden. 2004. Interleukin-17 family members and in-flammation. Immunity 21:467-476.
16. Kryczek, I., S. Wei, W. Gong, X. Shu, W. Szeliga, L. Vatan, L. Chen, G. Wang, and W. Zou. 2008. Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development. J. Immunol. 181:5842-5846.
17. London, C. A., V. L. Perez, and A. K. Abbas. 1999. Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. J. Immunol. 162:766-773.
18. Mazmanian, S. K., C. H. Liu, A. O. Tzianabos, and D. L. Kasper. 2005. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107-118.
19. Perlmutter, R. M., D. Hansburg, D. E. Briles, R. A. Nicolotti, and J. M. Davie. 1978. Subclass restriction of murine anti-carbohydrate antibodies. J. Immunol. 121:566-572.
20. Ruiz-Perez, B., D. R. Chung, A. H. Sharpe, H. Yagita, W. M. Kalka-Moll, M. H. Sayegh, D. L. Kasper, and A. O. Tzianabos. 2005. Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proc. Natl. Acad. Sci. USA 102:16753-16758.
21. Schrama, D., M. H. Andersen, P. Terheyden, L. Schroder, L. O. Pedersen, P. thor Straten, and J. C. Becker. 2001. Oligoclonal T-cell receptor usage of melanocyte differentiation antigen-reactive T cells in stage IV melanoma patients. Cancer Res. 61:493-496.
22. Stephen, T. L., M. Fabri, L. Groneck, T. A. Rohn, H. Hafke, N. Robinson, J. Rietdorf, D. Schrama, J. C. Becker, G. Plum, M. Kronke, H. Kropshofer, and W. M. Kalka-Moll. 2007. Transport of Streptococcus pneumoniae capsular polysaccharide in MHC class II tubules. PLoS Pathog. 3:e32.
23. Stingele, F., B. Corthesy, N. Kusy, S. A. Porcelli, D. L. Kasper, and A. O. Tzianabos. 2004. Zwitterionic polysaccharides stimulate T cells with no preferential Vbeta usage and promote anergy, resulting in protection against experimental abscess formation. J. Immunol. 172:1483-1490.
24. Straten, P. T., P. Guldberg, T. Seremet, R. A. Reisfeld, J. Zeuthen, and J. C. Becker. 1998. Activation of preexisting T cell clones by targeted interleukin 2 therapy. Proc. Natl. Acad. Sci. USA 95:8785-8790.
25. Tato, C. M., and J. J. O'Shea. 2006. Immunology: what does it mean to be just 17? Nature 441:166-168.
26. thor Straten, P., A. Barfoed, T. Seremet, I. Saeterdal, J. Zeuthen, and P. Guldberg. 1998. Detection and characterization of alpha-beta-T-cell clonality by denaturing gradient gel electrophoresis (DGGE). BioTechniques 25:244-250.
27. thor Straten, P., P. Guldberg, K. Gronbaek, M. R. Hansen, A. F. Kirkin, T. Seremet, J. Zeuthen, and J. C. Becker. 1999. In situ T cell responses against melanoma comprise high numbers of locally expanded T cell clonotypes. J. Immunol. 163:443-447.
28. Tzianabos, A. O., A. Chandraker, W. Kalka-Moll, F. Stingele, V. M. Dong, R. W. Finberg, R. Peach, and M. H. Sayegh. 2000. Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway. Infect. Immun. 68:6650-6655.
29. Tzianabos, A. O., R. W. Finberg, Y. Wang, M. Chan, A. B. Onderdonk, H. J. Jennings, and D. L. Kasper. 2000. T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria. J. Biol. Chem. 275:6733-6740.
30. Tzianabos, A. O., D. L. Kasper, R. L. Cisneros, R. S. Smith, and A. B. Onderdonk. 1995. Polysaccharide-mediated protection against abscess formation in experimental intra-abdominal sepsis. J. Clin. Investig. 96:2727-2731.
31. Tzianabos, A. O., A. B. Onderdonk, B. Rosner, R. L. Cisneros, and D. L. Kasper. 1993. Structural features of polysaccharides that induce intra-abdominal abscesses. Science 262:416-419.
32. Tzianabos, A. O., P. R. Russell, A. B. Onderdonk, F. C. Gibson III, C. Cywes, M. Chan, R. W. Finberg, and D. L. Kasper. 1999. IL-2 mediates protection against abscess formation in an experimental model of sepsis. J. Immunol. 163:893-897.
33. Tzianabos, A. O., J. Y. Wang, and J. C. Lee. 2001. Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides. Proc. Natl. Acad. Sci. USA 98:9365-9370.
34. Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-189.
35. Velez, C. D., C. J. Lewis, D. L. Kasper, and B. A. Cobb. 2009. Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation. Immunology 127:73-82.
36. Wang, Y., W. M. Kalka-Moll, M. H. Roehrl, and D. L. Kasper. 2000. Structural basis of the abscess-modulating polysaccharide A2 from Bacteroides fragilis. Proc. Natl. Acad. Sci. USA 97:13478-13483.
37. Watts, C. 2004. The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules. Nat. Immunol. 5:685-692.
38. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24:677-688.