Induction of Bim limits cytokine-mediated prolonged survival of neutrophils

Cell Death and Differentiation

Volumn 16, Issue 9, 2009, Pages 1248-1255

  Andina, N ^a   Conus, S ^a   Schneider, E M ^b   Fey, M F ^a   Simon, H U ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BIM PROTEIN; CYCLOHEXIMIDE; DACTINOMYCIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SEPTIC SHOCK; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; HUMANS; INTERLEUKIN-3; MEMBRANE PROTEINS; MICE; NEUTROPHILS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEPSIS;

EID: 69049110870     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.50     Document Type: Article

References (50)

1. Simon HU. Neutrophil apoptosis pathways and their modifications in inflammation. Immunol Rev 2003; 193: 101-110.
2. Lum JJ, Bren G, McClure R, Badley AD. Elimination of senescent neutrophils by TNF-related apoptosis-inducing ligand. J Immunol 2005; 175: 1232-1238.
3. Dibbert B, Weber M, Nikolaizik WH, Vogt P, Schöni MH, Blaser K et al. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation. Proc Natl Acad Sci USA 1999; 96: 13330-13335.
4. Saba S, Soong G, Greenberg S, Prince A. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol 2002; 27: 561-567.
5. Jonsson H, Allen P, Peng SL. Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat Med 2005; 11: 666-671.
6. Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S et al. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 2008; 205: 685-698.
7. Hallett JM, Leitch AE, Riley NA, Duffin R, Haslett C, Rossi AG. Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation. Trends Pharmacol Sci 2008; 29: 250-257.
8. Youle RJ, Strasser A. The Bcl-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
9. L and Bax-α-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood 1999; 93: 3106-3115.
10. Moulding DA, Akgul C, Derouet M, White MR, Edwards SW. Bcl-2 family expression in human neutrophils during delayed and accelerated apoptosis. J Leukoc Biol 2001; 70: 783-792.
11. Moulding DA, Quayle JA, Hart CA, Edwards SW. Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival. Blood 1998; 92: 2495-2502.
12. Epling-Burnette PK, Zhong B, Bai F, Jiang K, Bailey RD, Garcia R et al. Cooperative regulation of Mcl-1 by Janus kinase/STAT and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol 2001; 166: 7486-7495.
13. Chuang PI, Yee E, Karsan A, Winn RK, Harlan JM. A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils. Biochem Biophys Res Commun 1998; 249: 361-365.
14. Villunger A, O'Reilly LA, Holler N, Adams J, Strasser A. Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J Exp Med 2000; 192: 647-658.
15. Iwai K, Miyawaki T, Takizawa T, Konno A, Ohta K, Yachie A et al. Differential expression of Bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood 1994; 84: 1201-1208.
16. Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Köntgen F et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286: 1735-1738.
17. Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000; 10: 1201-1204.
18. Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing Bim expression and inhibiting mitochondrial cytochrome c release. Neuron 2001; 29 629-643.
19. Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A et al. Induction of Bim, a proapoptotic BH3-only Bcl-2 family member, is critical for neuronal apoptosis. Neuron 2001; 29: 615-628.
20. Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI et al. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 2003; 22 6653-6664.
21. Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK. Cell Death Differ 2005; 12: 1008-1014.
22. Villunger A, Scott C, Bouillet P, Strasser A. Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. Blood 2003; 101: 2393-2400.
23. O'Reilly LA, Cullen L, Visvader J, Lindeman GJ, Print C, Bath ML et al. The proapoptotic BH3-only protein Bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol 2000; 157: 449-461.
24. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999; 3: 287-296.
25. Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY et al Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J 2004; 377: 597-605.
26. Altznauer F, Martinelli S, Yousefi S, Thürig C, Schmid I, Conway EM et al. Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils. J Exp Med 2004; 199: 1343-1354.
27. Martinelli S, Urosevic M, Daryadel A, Oberholzer PA, Baumann C, Fey MF et al. Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation. J Biol Chem 2004; 279: 44123-44132.
28. Chen M, Huang L, Wang J. Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood 2007; 109: 4360-4367.
29. Dijkers PF, Birkenkamp KU, Lam EW, Thomas NS, Lammers JW, Koenderman L et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 2002; 156: 531-542.
30. Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM et al The forkhead transcription factor Foxo regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol 2002; 168: 5024-5031.
31. Gilley J, Coffer PJ, Ham J. Foxo transcription factors directly activate Bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 2003; 162: 613-622.
32. Jönsson M, Engström M, Jönsson JI. FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor Foxo3. Biochem Biophys Res Commun 2004; 318: 899-903.
33. Möller C, Alfredsson J, Engström M, Wootz H, Xiang Z, Lennartsson J et al. Stem cell factor promotes mast cell survival via inactivation of Foxo3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 2005; 106: 1330-1336.
34. Rosas M, Dijkers PF, Lindemans CL, Lammers JW, Koenderman L, Coffer PJ. IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with β-catenin relocalization. J Leukoc Biol 2006; 80: 186-195.
35. EL apoptotic function. J Biol Chem 2006; 281: 813-823.
36. Kirschnek S, Ying S, Fischer SF, Häcker H, Villunger A, Hochrein H et al. Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim. J Immunol 2005; 174: 671-679.
37. L upon IgE-receptor activation. Cell Death Differ 2005; 12: 136-144.
38. Bauer A, Kirschnek S, Häcker G. Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes. Cell Death Differ 2007; 14: 1714-1716.
39. Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X et al. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proc Natl Acad Sci USA 2004; 101: 7681-7686.
40. L and Bcl-2 on mitochondria in human B cells. Eur J Immunol 2005; 35: 971-976.
41. Downey GP, Butler JR, Tapper H, Fialkow L, Saltiel AR, Rubin BB et al Importance of MEK in neutrophil microbicidal responsiveness. J Immunol 1998; 160: 434-443.
42. Dimitriou ID, Clemenza L, Scotter AJ, Chen G, Guerra FM, Rottapel R. Putting out the fire: Coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunol Rev 2008; 224: 265-283.
43. Martinez-Moczygemba M, Huston DP. Proteasome regulation of βc signaling reveals a novel mechanism for heterotypic desensitization. J Clin Invest 2001; 108: 1797-1806.
44. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: Signals in resolution. Nat Immunol 2001; 2: 612-619.
45. Bellocchio S, Moretti S, Perruccio K, Fallarino F, Bozza S, Montagnoli C et al. TLRs govern neutrophil activity in aspergillosis. J Immunol 2004; 173: 7406-7415.
46. Kostylina G, Simon D, Fey MF, Yousefi S, Simon HU. Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A). Cell Death Differ 2008; 15: 134-142.
47. Martinelli S, Kostylina G, Niggli V, Baumann C, Fey MF, Wendel HG et al. Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils. Oncogene 2006; 25: 6915-6923.
48. Vassina EM, Yousefi S, Simon D, Zwicky C, Conus S, Simon HU. cIAP-2 and survivin contribute to cytokine-mediated delayed eosinophil apoptosis. Eur J Immunol 2006; 36: 1975-1984.
49. Yousefi S, Gold JA, Andina N, Lee JJ, Kelly AM, Kozlowski E et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med 2008; 14: 949-953.
50. Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S et al. Fatal hepatitis mediated by tumor necrosis factor TNFα requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity 2009; 30: 56-66.