Low penetrance breast cancer predisposition SNPs are site specific

Breast Cancer Research and Treatment

Volumn 117, Issue 1, 2009, Pages 151-159

  McInerney, Niall ^a,b   Colleran, Gabrielle ^a,b   Rowan, Andrew ^b   Walther, Axel ^b   Barclay, Ella ^b   Spain, Sarah ^b   Jones, Angela M ^b   Tuohy, Stephen ^a,b   Curran, Catherine ^a   Miller, Nicola ^a   Kerin, Michael ^a   Tomlinson, Ian ^b   Sawyer, Elinor ^b,c  

^a UNIVERSITY HOSPITAL GALWAY   (Ireland)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

8q24; Breast cancer; Colorectal cancer; Genetic susceptibility; Prostate cancer; West Ireland

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 2; PROTEIN TNCR9; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOMAL LOCALIZATION; CHROMOSOME 8Q; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IRELAND; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

BREAST NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; IRELAND; MIDDLE AGED; PENETRANCE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 69049105563     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0235-7     Document Type: Article

References (36)

1. AC Antoniou DF Easton 2006 Models of genetic susceptibility to breast cancer Oncogene 25 43 5898 5905 10.1038/sj.onc.1209879
2. PD Pharoah A Antoniou M Bobrow et al. 2002 Polygenic susceptibility to breast cancer and implications for prevention Nat Genet 31 1 33 36 10.1038/ng853
3. DF Easton KA Pooley AM Dunning et al. 2007 Genome-wide association study identifies novel breast cancer susceptibility loci Nature 447 7148 1087 1093 10.1038/nature05887
4. DJ Hunter P Kraft KB Jacobs et al. 2007 A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer Nat Genet 39 7 870 874 10.1038/ng2075
5. SN Stacey A Manolescu P Sulem et al. 2007 Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer Nat Genet 39 7 865 869 10.1038/ng2064
6. SN Stacey A Manolescu P Sulem et al. 2008 Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer Nat Genet 40 6 703 706 10.1038/ng.131
7. KE Driver H Song F Lesueur et al. 2008 Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population Carcinogenesis 29 2 333 341 10.1093/carcin/bgm284
8. H Ma G Jin Z Hu et al. 2006 Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women Int J Cancer 119 9 2173 2178 10.1002/ijc.22094
9. LT Amundadottir P Sulem J Gudmundsson et al. 2006 A common variant associated with prostate cancer in European and African populations Nat Genet 38 6 652 658 10.1038/ng1808
10. ML Freedman CA Haiman N Patterson et al. 2006 Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proc Natl Acad Sci USA 10338 14068 14073 10.1073/pnas.0605832103
11. J Gudmundsson P Sulem A Manolescu et al. 2007 Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 Nat Genet 39 5 631 637 10.1038/ng1999
12. CA Haiman N Patterson ML Freedman et al. 2007 Multiple regions within 8q24 independently affect risk for prostate cancer Nat Genet 39 5 638 644 10.1038/ng2015
13. M Yeager N Orr RB Hayes et al. 2007 Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 Nat Genet 39 5 645 649 10.1038/ng2022
14. FR Schumacher HS Feigelson DG Cox et al. 2007 A common 8q24 variant in prostate and breast cancer from a large nested case-control study Cancer Res 67 7 2951 2956 10.1158/0008-5472.CAN-06-3591
15. I Tomlinson E Webb L Carvajal-Carmona et al. 2007 A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 Nat Genet 39 8 984 988 10.1038/ng2085
16. BW Zanke CM Greenwood J Rangrej et al. 2007 Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 Nat Genet 39 8 989 994 10.1038/ng2089
17. M Ghoussaini H Song T Koessler et al. 2008 Multiple loci with different cancer specificities within the 8q24 gene desert J Natl Cancer Inst 100 13 962 966 10.1093/jnci/djn190
18. JS Witte 2007 Multiple prostate cancer risk variants on 8q24 Nat Genet 39 5 579 580 10.1038/ng0507-579
19. Houlston RS, Peto J (2004) Genetics and the common cancers. In Eeles RA, Easton DF, Ponder BAJ, Eng C (eds) Genetic predisposition to cancer, 2nd edn, Arnold, London
20. RA Eeles Z Kote-Jarai GG Giles et al. 2008 Multiple newly identified loci associated with prostate cancer susceptibility Nat Genet 40 3 316 321 10.1038/ng.90
21. G Thomas KB Jacobs M Yeager et al. 2008 Multiple loci identified in a genome-wide association study of prostate cancer Nat Genet 40 3 310 315 10.1038/ng.91
22. J Gudmundsson P Sulem T Rafnar et al. 2008 Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer Nat Genet 40 3 281 283 10.1038/ng.89
23. E Jaeger E Webb K Howarth et al. 2008 Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk Nat Genet 40 1 26 28 10.1038/ng.2007.41
24. A Tenesa SM Farrington JG Prendergast et al. 2008 Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 Nat Genet 40 5 631 637 10.1038/ng.133
25. P Broderick L Carvajal-Carmona AM Pittman et al. 2007 A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk Nat Genet 39 11 1315 1317 10.1038/ng.2007.18
26. IP Tomlinson E Webb L Carvajal-Carmona et al. 2008 A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 Nat Genet 40 5 623 630 10.1038/ng.111
27. Houlston RS, Webb E, Broderick P et al (2008) Meta-analysis of genome-wide association data identifies 4 novel susceptibility loci for colorectal cancer. Nat Genet (in press)
28. EW Hill MA Jobling DG Bradley 2000 Y-chromosome variation and Irish origins Nat Genet 404 6776 351 352 10.1038/35006158
29. J Marchini B Howie S Myers et al. 2007 A new multipoint method for genome-wide association studies by imputation of genotypes Nat Genet 39 7 906 913 10.1038/ng2088
30. JP Higgins SG Thompson JJ Deeks DG Altman 2003 Measuring inconsistency in meta-analyses BMJ 327 7414 557 560 10.1136/bmj.327.7414.557
31. O Fletcher N Johnson L Gibson et al. 2008 Association of genetic variants at 8q24 with breast cancer risk Cancer Epidemiol Biomarkers Prev 17 3 702 705 10.1158/1055-9965.EPI-07-2564
32. M Garcia-Closas P Hall H Nevanlinna et al. 2008 Heterogeneity of breast cancer associations with five susceptibility Loci by clinical and pathological characteristics PLoS Genet 4 4 1 10 10.1371/journal.pgen.1000054
33. GY Wang CQ Lu RM Zhang et al. 2008 The E-cadherin gene polymorphism 160C-> A and cancer risk: a HuGE review and meta-analysis of 26 case-control studies Am J Epidemiol 167 1 7 14
34. HS Qureshi MD Linden G Divine et al. 2006 E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters Am J Clin Pathol 125 3 377 385
35. S Masciari N Larsson J Senz et al. 2007 Germline E-cadherin mutations in familial lobular breast cancer J Med Genet 44 11 726 731 10.1136/jmg.2007.051268
36. X Solé P Hernández ML de Heredia et al. 2008 Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility BMC Genomics 9 12 10.1186/1471-2164-9-12