Post-exposure treatment with nasal atropine methyl bromide protects against microinstillation inhalation exposure to sarin in guinea pigs

Toxicology and Applied Pharmacology

Volumn 239, Issue 3, 2009, Pages 251-257

  Che, Magnus M ^a   Conti, Michele ^b   Chanda, Soma ^a   Boylan, Megan ^b   Sabnekar, Praveena ^b   Rezk, Peter ^b   Amari, Ethery ^a   Sciuto, Alfred M ^b   Gordon, Richard K ^a   Doctor, Bhupendra P ^a   Nambiar, Madhusoodana P ^a,c  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

Cholinesterases; Guinea pigs; Inhalation exposure; Nerve agents; Neuroprotection; Organophosphates; Respiratory toxicity; Seizure status epilepticus

Indexed keywords

ACETYLCHOLINESTERASE; ALKALINE PHOSPHATASE; ATROPINE METHYL BROMIDE; CHOLINESTERASE; LUNG SURFACTANT; SARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; ENZYME ACTIVITY; GUINEA PIG; HEART RATE; LUNG INJURY; LUNG LAVAGE; LUNG LOBE; LUNG TOXICITY; MALE; METABOLISM; NONHUMAN; OXYGEN SATURATION; PROTECTION; PROTEIN EXPRESSION; PULSE RATE; SURVIVAL RATE; TREMOR; WEIGHT REDUCTION;

ACETYLCHOLINESTERASE; ADMINISTRATION, INTRANASAL; ALKALINE PHOSPHATASE; ANIMALS; ATROPINE DERIVATIVES; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; BUTYRYLCHOLINESTERASE; CELL COUNT; CHEMICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART RATE; INHALATION EXPOSURE; INSTILLATION, DRUG; LUNG; MALE; ORGAN SIZE; OXYGEN; PARASYMPATHOLYTICS; PULMONARY EDEMA; PULMONARY SURFACTANTS; SARIN; TIME FACTORS;

ANIMALIA; CAVIA;

EID: 69049101904     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.06.002     Document Type: Article

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